期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 27, 页码 8360-8363出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b04414
关键词
-
资金
- National Natural Science Foundation of China [21232003, 21472057, 21572074]
- [201422]
- [CCNU15A02007]
- [2015CFA033]
The first copper-catalyzed asymmetric decarboxylative [4 + 1] cycloaddition of propargylic carbamates and sulfur ylides was successfully developed. This strategy led to a series of chiral indolines with synthetically flexible alkyne groups in good yields and with high enantio- and diastereoselectivities (up to 99% yield, 98% ee, and >95:5 dr). A possible mechanism and stereoinduction mode with copper-allenylidenes were proposed as the possible dipolar intermediate.
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