Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring

Article Allergy

Prepregnancy body mass index and risk of childhood asthma

Natalie A. A. Rosenquist et al.

Summary: This study aims to investigate the relationship between maternal prepregnancy obesity and childhood asthma risk. The results suggest that higher prepregnancy BMI is associated with a modestly increased risk of childhood asthma.

ALLERGY (2023)

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Letter Critical Care Medicine

Elevated Childhood Insulin-related Asthma Is a Risk Factor for Reduced Lung Function

Tara F. Carr et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

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Article Public, Environmental & Occupational Health

Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers

Kim Ramil C. Montaniel et al.

Summary: Maternal obesity is linked to increased DPPIV activity in male offspring, and treatment with DPPIV inhibitor can delay the progression of obesity and metabolic diseases in male offspring of obese mothers.

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2022)

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Article Critical Care Medicine

The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma

Michael C. Peters et al.

Summary: This study demonstrates that insulin resistance (IR) is common in asthma and is associated with lower lung function, accelerated decline of lung function, and suboptimal responses to bronchodilator and corticosteroid treatments.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Editorial Material Oncology

Epigenetics of asthma-the field continues to evolve

Deepa Rastogi

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Medicine, Research & Experimental

Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice

Gina N. Calco et al.

Summary: Obesity-induced asthma shows poor response to current pharmacological interventions, suggesting that classical eosinophilic inflammation is not the mechanism. This study on diet-induced obese mice reveals that insulin increases sensory innervation in the airways and leads to airway hyperreactivity. Therefore, controlling metabolic syndrome and limiting reflex-mediated bronchoconstriction may be a more effective approach in reducing asthma exacerbations in obese individuals and patients with asthma.

JCI INSIGHT (2022)

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Article Physiology

Metformin prevents airway hyperreactivity in rats with dietary obesity

Gina N. Calco et al.

Summary: Increased insulin levels are associated with obesity-related airway hyperreactivity and asthma. Metformin, an antidiabetic drug, was found to prevent the development of airway hyperreactivity in male rats on a high-fat diet by reducing circulating insulin levels. This study suggests that insulin-targeting medications may be an effective treatment for obesity-related asthma.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

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Article Physiology

Pioglitazone prevents obesity-related airway hyperreactivity and neuronal M2 receptor dysfunction

Becky J. Proskocil et al.

Summary: Obesity-related asthma presents with severe symptoms and poor response to current treatments. The hypoglycemic drug pioglitazone has been shown to prevent airway hyperreactivity and M-2 receptor dysfunction in obese rats.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

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Article Nutrition & Dietetics

Vitamin E: necessary nutrient for neural development and cognitive function

Maret G. Traber

Summary: Vitamin E is essential for embryonic development, with deficiency leading to developmental abnormalities and disruption of the nervous system. Studying the molecular dysregulation caused by vitamin E deficiency provides important insights into abnormal neurogenesis and embryonic malformations.

PROCEEDINGS OF THE NUTRITION SOCIETY (2021)

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Review Nutrition & Dietetics

Overweight and obesity in pregnancy: their impact on epigenetics

Christoph Reichetzeder

Summary: The prevalence of obesity has reached epidemic levels globally in the past few decades, leading to a drastic increase in obesity during pregnancy, which is associated with impaired outcomes for both mothers and children. Studies suggest that maternal obesity can have long-term consequences on offspring, increasing the risk for obesity and cardiometabolic disease later in life. In addition to genetic mechanisms, evidence shows that maternal obesity can induce epigenetic alterations, affecting offspring phenotype and influencing the risk of obesity and cardiometabolic disease later on.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)

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Article Public, Environmental & Occupational Health

Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers

Matthew Bucher et al.

Summary: The offspring of obese mothers exhibit dyslipidemia and insulin resistance from birth, with placental abnormalities potentially contributing to these metabolic disturbances. Placental markers of lipid and energy metabolism are altered in obese mothers, impacting the health and wellbeing of the offspring in the long-term.

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2021)

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Review Neurosciences

B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

Carlos Alberto Calderon-Ospina et al.

CNS NEUROSCIENCE & THERAPEUTICS (2020)

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Article Physiology

Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice

Zhenying Nie et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Review Physiology

Airway Innervation and Plasticity in Asthma

L. E. M. Kistemaker et al.

PHYSIOLOGY (2019)

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Article Cell Biology

Eosinophil and airway nerve interactions in asthma

Matthew G. Drake et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2018)

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Article Cell Biology

Eosinophils increase airway sensory nerve density in mice and in human asthma

Matthew G. Drake et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Multidisciplinary Sciences

Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D)

Weizhe Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Respiratory System

Insulin resistance modifies the association between obesity and current asthma in adults

Juan Carlos Cardet et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

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Article Allergy

Body mass index, adipokines and insulin resistance in asthmatic children and adolescents

Rosinha Morishita et al.

JOURNAL OF ASTHMA (2016)

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Review Endocrinology & Metabolism

Obesity and asthma: beyond TH2 inflammation

Luiz O. S. Leiria et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

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Review Pediatrics

Maternal obesity and immune dysregulation in mother and infant: A review of the evidence

Giulia S. Rizzo et al.

PAEDIATRIC RESPIRATORY REVIEWS (2015)

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Article Biochemistry & Molecular Biology

Hyperinsulinemia Potentiates Airway Responsiveness to Parasympathetic Nerve Stimulation in Obese Rats

Zhenying Nie et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Tissue Optical Clearing, Three-Dimensional Imaging, and Computer Morphometry in Whole Mouse Lungs and Human Airways

Gregory D. Scott et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

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Review Pediatrics

Maternal Obesity in Pregnancy, Gestational Weight Gain, and Risk of Childhood Asthma

Erick Forno et al.

PEDIATRICS (2014)

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Article Allergy

Association of insulin resistance with bronchial hyperreactivity

Kyung-Mook Kim et al.

ASIA PACIFIC ALLERGY (2014)

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Article Biochemistry & Molecular Biology

Quantifying Nerve Architecture in Murine and Human Airways Using Three-Dimensional Computational Mapping

Gregory D. Scott et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

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Article Pharmacology & Pharmacy

Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction

Zhenying Nie et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

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Article Multidisciplinary Sciences

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes

Martin Heni et al.

PLOS ONE (2011)

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Article Anesthesiology

Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision

Peyman Sahbaie et al.

PAIN (2009)

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Article Endocrinology & Metabolism

Influence of maternal obesity on insulin sensitivity and secretion in offspring

Geltrude Mingrone et al.

DIABETES CARE (2008)

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Article Endocrinology & Metabolism

Inhaled insulin in patients with asthma and chronic obstructive pulmonary disease

Sunder Mudaliar et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2007)

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Review Physiology

Reflex regulation of airway smooth muscle tone

Brendan J. Canning

JOURNAL OF APPLIED PHYSIOLOGY (2006)

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Article Endocrinology & Metabolism

Insulin downregulates M2-muscarinic receptors in adult rat atrial cardiomyocytes:: a link between obesity and cardiovascular complications

A Pathak et al.

INTERNATIONAL JOURNAL OF OBESITY (2005)

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Article Biochemistry & Molecular Biology

Airway smooth muscle cells express functional neurokinin-1 receptors and the nerve-derived preprotachykinin-A gene - Regulation by passive sensitization

K Maghni et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)

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Review Allergy

Role of tachykinins in asthma

GF Joos et al.

ALLERGY (2000)

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Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring

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