4.7 Article

Moderate exercise induces trained immunity in macrophages

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Physiology

Effect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients

Bruno Gualano et al.

Summary: This randomized controlled study investigated the effect of a single bout of exercise before a booster dose of a SARS-CoV-2 vaccine on immunogenicity in patients with spondyloarthritis. The results showed that exercise did not enhance the immune response to the vaccine in these patients.

JOURNAL OF APPLIED PHYSIOLOGY (2022)

Article Cell Biology

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway

Huaili Jiang et al.

Summary: This study revealed that M1-derived exosomes containing HOTTIP activate the TLR5/NF-kappa B signaling pathway by competitively sponging miR-19a-3p and miR-19b-3p, thereby suppressing the progression of head and neck squamous cell carcinoma (HNSCC). Additionally, M1-derived exosomes and HOTTIP induce the polarization of circulating monocytes towards an M1 phenotype, providing new insights into HNSCC immunotherapy.

CELL DEATH & DISEASE (2022)

Article Cell Biology

Myeloid cell-specific mutation of Spi1 selectively reduces M2-biased macrophage numbers in skeletal muscle, reduces age-related muscle fibrosis and prevents sarcopenia

Ying Wang et al.

Summary: Intramuscular macrophages play key roles in regulating skeletal muscle response to injury and disease. Changes in the numbers and phenotype of these macrophages during aging can influence the aging process. A study using a mouse model with a myeloid cell-specific mutation of Spi1 showed that this mutation reduced the numbers of M2 phenotype macrophages in aging muscles, and also reduced age-related muscle fibrosis and sarcopenia. These findings highlight the significance of intramuscular M2-biased macrophages in promoting detrimental, age-related changes in muscle.

AGING CELL (2022)

Article Biology

Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

Parastoo Boroumand et al.

Summary: During obesity and high fat-diet feeding, there is an increase in pro-inflammatory macrophages in adipose tissue as well as invasive Ly6C(high) monocytes produced by the bone marrow. This study explores the relationship between bone marrow adipocytes and Ly6C(high) monocytes, and finds that the whitening of bone marrow adipocytes precedes the rise of adipose tissue macrophages during high fat-diet feeding in mice. Ex vivo treatment of bone marrow cells with conditioned media from bone marrow adipocytes or white adipocytes also favors the presence of Ly6C(high) monocytes. Furthermore, there is a metabolic reprogramming and mitochondrial fission in monocytes before the shift towards Ly6C(high) phenotype.
Article Biochemistry & Molecular Biology

Tumor-associated macrophages in direct contact with prostate cancer cells promote malignant proliferation and metastasis through NOTCH1 pathway

Fei Shi et al.

Summary: Direct contact between M2 macrophages and PCa cells promotes cancer progression by enhancing proliferation and invasion through the NOTCH1 signaling pathway. Targeting the NOTCH1 pathway could potentially provide a therapeutic strategy for prostate cancer.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Review Medicine, Research & Experimental

Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature

Matheus Pelinski da Silveira et al.

Summary: Acute viral respiratory infections are major global infectious diseases. COVID-19, caused by SARS-CoV-2, became a pandemic in 2020. Regular physical exercise can strengthen the immune system and potentially reduce the risk and severity of viral infections, including COVID-19.

CLINICAL AND EXPERIMENTAL MEDICINE (2021)

Review Neurosciences

Interpreting 'anti-inflammatory' cytokine responses to exercise: focus on interleukin-10

Hashim Islam et al.

Summary: Interpreting changes in circulating cytokine concentrations as evidence for altered inflammation may overlook important functional changes in cytokine action at the tissue/cellular level, due to factors influencing cytokine function. Therefore, relying solely on changes in cytokine concentrations may miss significant alterations in inflammatory processes.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

Editorial Material Rheumatology

Exercise exerts anti-inflammatory effects on muscle via the JAK-STAT pathway

Joanna Clarke

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Cell Biology

Effect of Physical Training on Exercise-Induced Inflammation and Performance in Mice

Luiz Alexandre Medrado de Barcellos et al.

Summary: Acute high intensity exercise induces inflammation, but physical training can attenuate exercise-induced inflammation. Training enhances immune adaptations and decreases inflammatory response post-exercise.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Endocrinology & Metabolism

Regular aerobic exercise activates PDGF-BB/PDGFR-β signaling and modulates the inflammatory-anti-inflammatory balance in diet-induced obese mice

Xishuai Wang et al.

Summary: Regular aerobic exercise improves adiposity and dyslipidemia induced by HFD feeding, modulating the inflammatory-anti-inflammatory balance and activating cardioprotective factors through PDGF-BB/PDGFR-beta signaling pathway.

OBESITY RESEARCH & CLINICAL PRACTICE (2021)

Article Endocrinology & Metabolism

Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming

Hongji Zhang et al.

Summary: The research demonstrates that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype through itaconate metabolism.

NATURE METABOLISM (2021)

Article Biochemistry & Molecular Biology

IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity

Yalda Karimi et al.

INNATE IMMUNITY (2020)

Review Rheumatology

Exercise and inflammation

George S. Metsios et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2020)

Review Biochemistry & Molecular Biology

Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs

Debora da Luz Scheffer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Hospitality, Leisure, Sport & Tourism

Exercise immunology: Future directions

David C. Nieman et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2020)

Review Physiology

Inflammatory Effects of High and Moderate Intensity Exercise-A Systematic Review

Erica Cerqueira et al.

FRONTIERS IN PHYSIOLOGY (2020)

Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Therapeutic targeting of trained immunity

Willem J. M. Mulder et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Biochemistry & Molecular Biology

MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells

Mikel Aristorena et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation

Senthil Kumaran Satyanarayanan et al.

NATURE COMMUNICATIONS (2019)

Article Biotechnology & Applied Microbiology

DEBrowser: interactive differential expression analysis and visualization tool for count data

Alper Kucukural et al.

BMC GENOMICS (2019)

Review Hospitality, Leisure, Sport & Tourism

The compelling link between physical activity and the body's defense system

David C. Nieman et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2019)

Review Immunology

Itaconate: the poster child of metabolic reprogramming in macrophage function

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Hematology

Moderate exercise training decreases inflammation in transgenic sickle cell mice

Emmanuelle Charrin et al.

BLOOD CELLS MOLECULES AND DISEASES (2018)

Article Multidisciplinary Sciences

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills et al.

NATURE (2018)

Article Medical Laboratory Technology

Mitochondria in innate immune signaling

Balaji Banoth et al.

TRANSLATIONAL RESEARCH (2018)

Review Physiology

Mitochondria, Oxidative Stress and Innate Immunity

Yuxin Chen et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Immunology

NF-κB, inflammation, immunity and cancer: coming of age

Koji Taniguchi et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Biochemical Research Methods

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

M. Ryan Corces et al.

NATURE METHODS (2017)

Review Urology & Nephrology

The immunology of atherosclerosis

Anton Gistera et al.

NATURE REVIEWS NEPHROLOGY (2017)

Review Immunology

Mitochondrial Control of Innate Immunity and Inflammation

Hyo Sun Jin et al.

IMMUNE NETWORK (2017)

Article Immunology

A guiding map for inflammation

Mihai G. Netea et al.

NATURE IMMUNOLOGY (2017)

Review Immunology

Immunometabolism governs dendritic cell and macrophage function

Luke A. J. O'Neill et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Review Biotechnology & Applied Microbiology

Resolution of inflammation: a new therapeutic frontier

James N. Fullerton et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Multidisciplinary Sciences

An Optimized Protocol to Analyze Glycolysis and Mitochondrial Respiration in Lymphocytes

Javier Traba et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)

Review Immunology

A guide to immunometabolism for immunologists

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Review Biochemistry & Molecular Biology

Homeostasis, Inflammation, and Disease Susceptibility

Maya E. Kotas et al.

Article Endocrinology & Metabolism

Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice

Roberto Codella et al.

JOURNAL OF DIABETES RESEARCH (2015)

Review Rheumatology

Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation

Fabiana B. Benatti et al.

NATURE REVIEWS RHEUMATOLOGY (2015)

Review Biochemistry & Molecular Biology

Integrative Biology of Exercise

John A. Hawley et al.

Review Immunology

Macrophage heterogeneity in tissues: phenotypic diversity and functions

Siamon Gordon et al.

IMMUNOLOGICAL REVIEWS (2014)

Article Biochemistry & Molecular Biology

Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE

Alex J. Freemerman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Urology & Nephrology

Evidence for Anti-Inflammatory Effects of Exercise in CKD

Joao L. Viana et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Review Immunology

The immunomodulating role of exercise in metabolic disease

Graeme I. Lancaster et al.

TRENDS IN IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

Liangchun Yang et al.

NATURE COMMUNICATIONS (2014)

Article Immunology

Metabolic reprograming in macropage polarization

Silvia Galvan-Pena et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Immunology

Innate immune activation in neurodegenerative disease

Michael T. Heneka et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Review Immunology

Metabolic Pathways in Immune Cell Activation and Quiescence

Erika L. Pearce et al.

IMMUNITY (2013)

Article Immunology

Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7

Mateo de las Casas-Engel et al.

JOURNAL OF IMMUNOLOGY (2013)

Review Cell Biology

Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization

Roman Guenthner et al.

MEDIATORS OF INFLAMMATION (2013)

Article Multidisciplinary Sciences

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Sport Sciences

Effect of exercise training intensity on murine T-regulatory cells and vaccination response

J. Wang et al.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2012)

Review Hospitality, Leisure, Sport & Tourism

Clinical implications of exercise immunology

David C. Nieman

JOURNAL OF SPORT AND HEALTH SCIENCE (2012)

Article Physiology

Lack of Exercise Is a Major Cause of Chronic Diseases

Frank W. Booth et al.

COMPREHENSIVE PHYSIOLOGY (2012)

Review Multidisciplinary Sciences

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

Douglas R. Green et al.

SCIENCE (2011)

Review Medical Laboratory Technology

Effect of exercise training on chronic inflammation

Kristen M. Beavers et al.

CLINICA CHIMICA ACTA (2010)

Review Medicine, General & Internal

Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases

R. H. Straub et al.

JOURNAL OF INTERNAL MEDICINE (2010)

Article Multidisciplinary Sciences

A CREB-C/EBPβ cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

Daniela Ruffell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Moderate exercise is an antioxidant:: Upregulation of antioxidant genes by training

Mari-Carmen Gomez-Cabrera et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Review Physiology

Muscle as an endocrine organ: Focus on muscle-derived interleukin-6

Bente K. Pedersen et al.

PHYSIOLOGICAL REVIEWS (2008)

Review Physiology

Toll like receptor 4: Link to the anti-inflammatory effects of exercise?

Michael G. Flynn et al.

EXERCISE AND SPORT SCIENCES REVIEWS (2006)

Article Sport Sciences

Regular tai chi chuan exercise enhances functional mobility and CD4CD25 regulatory T cells

SH Yeh et al.

BRITISH JOURNAL OF SPORTS MEDICINE (2006)

Review Physiology

The anti-inflammatory effect of exercise

AMW Petersen et al.

JOURNAL OF APPLIED PHYSIOLOGY (2005)

Article Biochemistry & Molecular Biology

C/EBPβ regulation in lipopolysaccharide-stimulated macrophages

MN Bradley et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human U937 monocytic cells

LH Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)