期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 10, 页码 3294-3297出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b00180
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资金
- National Natural Science Foundation of China (NSFC) [21404096, U1463202]
- Fundamental Research Funds for the Central Universities of China [WK2060190022, WK2060190026, WK3430000001]
- Anhui Provincial Natural Science Foundation [1608085MB24]
A pharmaceutical-oriented, transition metal -free, cyanide-free one-step direct transformation of methylarenes to aryl nitriles is described. For the dimethylarenes, the selectivity can be well-controlled to form mononitriles or dinitriles. Enantioenriched nitriles can also be synthesized by this method. As a pharmaceutically practical method, the antidepressant drug citalopram was synthesized from cheap and commercially abundant m-xylene on a gram scale in high yield, avoiding transition metal residues and toxic cyanides.
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