期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 9, 页码 2881-2884出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b10425
关键词
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资金
- International Research Training Group 1404 'Self-organized Materials for Optoelectronics' (DFG)
- Sofia University Scientific Fund [77/2015]
Biocompatible organic dyes emitting in the near-infrared are highly desirable in fluorescence imaging techniques. Herein we report a synthetic approach for building novel small peri-guanidine-fused naphthalene monoimide and perylene monoimide chromophores. The presented structures possess near-infrared absorption and emission, high photostability, and good water solubility. After a fast cellular uptake, they selectively stain mitochondria with a low background in live and fixed cells. They can be additionally modified in a one-step reaction with functional groups for covalent labeling of proteins. The low cytotoxicity allows a long time exposure of live cells to the dyes without the necessity of washing. Successful application in localization super-resolution microscopy was demonstrated in phosphate-buffered saline without any reducing or oxidizing additives.
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