期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 159, 期 6, 页码 572-597出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ajcp/aqad042
关键词
transformation; follicular lymphoma; diffuse large B-cell lymphoma; high-grade B-cell lymphoma; TdT; lymphoblastic
类别
The 2021 Society for Hematopathology and European Association for Haematopathology Workshop focused on the molecular and cytogenetic mechanisms of transformation and transdifferentiation in lymphoid neoplasms. Gene alteration analysis and expression profiling were performed on 45 cases, revealing distinct categories of transformation in diffuse large B-cell lymphoma/high-grade B-cell lymphoma with rearrangements of MYC and BCL2. Cytogenetic abnormalities, such as MYC and NOTCH1 rearrangements, as well as single gene alterations, including TP53, were identified as important factors in transformation.
Objectives The 2021 Society for Hematopathology and European Association for Haematopathology Workshop addressed the molecular and cytogenetic underpinnings of transformation and transdifferentiation in lymphoid neoplasms. Methods Session 4, Transformations of Follicular Lymphoma, and session 5, Transformations of Other B-Cell Lymphomas, included 45 cases. Gene alteration analysis and expression profiling were performed on cases with submitted formalin-fixed, paraffin embedded tissue. Results The findings from session 4 suggest that diffuse large B-cell lymphoma/high-grade B-cell lymphoma with rearrangements of MYC and BCL2 is a distinct category arising from the constraints of a preexisting BCL2 translocation. TdT expression in aggressive B-cell lymphomas is associated with MYC rearrangements, immunophenotypic immaturity, and a dismal prognosis but must be differentiated from lymphoblastic -lymphoma. Cases in session 5 illustrated unusual morphologic and immunophenotypic patterns of transformation. Additionally, the findings support the role of cytogenetic abnormalities-specifically, MYC and NOTCH1 rearrangements-as well as single gene alterations, including TP53, in transformation. Conclusions Together, these unique cases and their accompanying molecular and cytogenetic data suggest potential mechanisms for and unusual patterns of transformation in B-cell lymphomas and indicate numerous opportunities for further study.
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