期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 160, 期 1, 页码 72-77出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ajcp/aqad015
关键词
Pediatric; Rotational thromboelastometry; Coagulation; Transfusion
类别
The objective of this study was to establish normal pediatric reference intervals (PRIs) for rotational thromboelastometry (ROTEM) Delta assays in a representative group of healthy children aged 0 to 18 years. A total of 20 patients from 5 different age groups were included, and two sets of PRIs were defined based on age. The PRIs were embedded in the electronic medical record for easy interpretation of ROTEM results.
Objectives: The aim of our investigation was to establish normal pediatric reference intervals (PRIs) for rotational thromboelastometry (ROTEM) Delta assays in a representative group of healthy children, 0 to 18 years of age, at our institution.Methods: This was a prospective study of healthy pediatric patients undergoing elective minor surgery requiring placement of an intravenous cannula. The sample size for patients was 20 per age group of either sex from 5 different age groups based on coagulation system maturity: 0 to 6 or fewer months, more than 6 to 12 or fewer months, more than 1 year to 5 or fewer years, more than 5 to 11 or fewer years, and more than 11 to 18 or fewer years. ROTEM Delta assays assessed include the EXTEM, INTEM, and FIBTEM.Results: We defined 2 sets of ROTEM PRIs for our patient population: one for patients 11 years or younger and one for children more than 11 years of age. For those 11 years or younger, the PRIs were derived from the 2.5th and 97.5th percentiles from the 0 to 11 age groups. For those older than 11 years, previously published adult reference intervals validated internally with adult normal samples were used.Conclusions: The 2 sets of PRIs were embedded into our electronic medical record, allowing clinicians to easily interpret their patient's ROTEM results against age-verified reference ranges, enabling them to make informed transfusion decisions.
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