Racial and ethnic differences in neuropsychiatric symptoms and progression to incident cognitive impairment among community-dwelling participants

Article Clinical Neurology

Black and White individuals differ in dementia prevalence, risk factors, and symptomatic presentation

Jack C. Lennon et al.

Summary: Despite lower dementia prevalence, Black participants with dementia had more dementia risk factors, as well as greater cognitive impairment and neuropsychiatric symptom severity than White participants.

ALZHEIMERS & DEMENTIA (2022)

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Article Psychiatry

Associations Between Neuropsychiatric Symptoms and Neuropathological Diagnoses of Alzheimer Disease and Related Dementias

Davangere P. Devanand et al.

Summary: This study analyzed 1808 brains and found a higher prevalence of hallucinations in patients with Lewy body disease and Alzheimer disease compared to those with just Lewy body disease. The criteria of apathy and disinhibition in behavioral variant frontotemporal lobar degeneration were supported. Additionally, patients with hippocampal sclerosis often displayed increased apathy and disinhibition.

JAMA PSYCHIATRY (2022)

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Article Public, Environmental & Occupational Health

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease 2019

Emma Nichols et al.

Summary: With projected trends in population ageing and growth, the number of people with dementia is expected to increase. Understanding the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritization, with a focus on potentially modifiable risk factors.

LANCET PUBLIC HEALTH (2022)

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Article Clinical Neurology

The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity

Ganesh M. Babulal et al.

Summary: Baseline differences in depression and antidepressant use were observed among cognitively normal older adults in different ethnoracial groups, and depression was found to independently predict a faster progression to incident cognitive impairment across these groups.

ALZHEIMERS & DEMENTIA (2022)

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Article Medicine, General & Internal

Association of Race and Ethnicity With Incidence of Dementia Among Older Adults

Erica Kornblith et al.

Summary: This study investigated dementia incidence among older veterans in the US based on race and ethnicity, revealing significant differences in dementia rates among different racial and ethnic groups. The findings suggest a need for further research to understand the underlying mechanisms responsible for these disparities.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Review Neurosciences

Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions

Luis Aguera-Ortiz et al.

Summary: Psychotic phenomena are severe and disruptive symptoms in dementia patients, occurring in 30% to 50% of cases. Current treatments have limited results and adverse effects. This review discusses the need for new treatments and proposes improvements in symptom definition, clinical trial design, and evaluation. It also explores the neurobiological basis of symptoms and provides an overview of existing pharmacological and non-pharmacological treatments. The review highlights the importance of better defining and measuring psychotic symptoms in dementia and suggests potential therapeutic targets.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Editorial Material Medicine, General & Internal

Racial and Ethnic Disparities in Dementia Care Next Steps

Norma B. Coe et al.

JAMA NETWORK OPEN (2022)

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Article Geriatrics & Gerontology

Ethnic Differences Between Hispanics and Non-Hispanic Whites in Neuropsychiatric Symptoms Predict Conversion to Mild Cognitive Impairment

Bhaskar Thakur et al.

Summary: The study aims to investigate the impact of neuropsychiatric symptoms (NPS) subtypes on progression to mild cognitive impairment (MCI) by ethnicity. Three NPS subtypes were identified and validated internally, with psychomotor apathy factor being the best predictor for MCI in non-Hispanics, and physical behavior factor being the most predictive in Hispanics. A high score in affective mood factor also tended to increase the risk of MCI in Hispanics. The differential prediction of MCI progression by NPS subtypes in Hispanics and non-Hispanic whites could help in monitoring individuals at risk of MCI.

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2021)

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Article Clinical Neurology

Psychosis in neurodegenerative disease: differential patterns of hallucination and delusion symptoms

Georges Naasan et al.

Summary: This study compared the rates and content of psychosis in patients with different neurodegenerative diseases. It found that patients with Lewy body disease/Alzheimer's disease pathology were more likely to have hallucinations, while patients with FTLD-TDP were more likely to have delusions. The data suggests that the nature and content of psychosis can provide valuable information about underlying neurodegenerative pathology.

BRAIN (2021)

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Article Clinical Neurology

2021 Alzheimer's disease facts and figures

[Anonymous]

Summary: Alzheimer's disease has a significant impact on individuals and society as a whole, with a large number of patients in the United States and a potential for continued growth in the future. The value of unpaid caregivers has increased despite a decline in their numbers, and healthcare costs are on the rise. Racial and ethnic disparities in healthcare persist, highlighting the need for greater diversity in dementia care workforce and clinical trials.

ALZHEIMERS & DEMENTIA (2021)

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Review Geriatrics & Gerontology

Neuropsychiatric Symptoms in Mild Cognitive Impairment: A Literature Review

Evangelia Martin et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2020)

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Article Clinical Neurology

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Ganesh M. Babulal et al.

ALZHEIMERS & DEMENTIA (2019)

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Article Clinical Neurology

Association between enrollment factors and incident cognitive impairment in Blacks and Whites: Data from the Alzheimer's Disease Center

Carey E. Gleason et al.

ALZHEIMERS & DEMENTIA (2019)

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Article Clinical Neurology

Time course of neuropsychiatric symptoms and cognitive diagnosis in National Alzheimer's Coordinating Centers volunteers

Elizabeth A. Wise et al.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2019)

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Review Psychology, Clinical

Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria

Zahinoor Ismail et al.

INTERNATIONAL PSYCHOGERIATRICS (2018)

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Article Clinical Neurology

Cross-Ethnic Differences in the Severity of Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment and Alzheimer's Disease

Ricardo Salazar et al.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2017)

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Article Clinical Neurology

Racial disparities in neurologic health care access and utilization in the United States

Altaf Saadi et al.

NEUROLOGY (2017)

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Article Psychiatry

Prevalence of Depression in Patients With Mild Cognitive Impairment A Systematic Review and Meta-analysis

Zahinoor Ismail et al.

JAMA PSYCHIATRY (2017)

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Article Clinical Neurology

Inequalities in dementia incidence between six racial and ethnic groups over 14 years

Elizabeth Rose Mayeda et al.

ALZHEIMERS & DEMENTIA (2016)

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Article Clinical Neurology

Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment

Zahinoor Ismail et al.

ALZHEIMERS & DEMENTIA (2016)

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Article Geriatrics & Gerontology

Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia

Sarah N. Forrester et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2016)

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Article Clinical Neurology

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

Qing-Fei Zhao et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

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Article Clinical Neurology

Noncognitive symptoms of early Alzheimer disease A longitudinal analysis

Mary Clare Masters et al.

NEUROLOGY (2015)

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Article Mathematical & Computational Biology

Optimal full matching for survival outcomes: a method that merits more widespread use

Peter C. Austin et al.

STATISTICS IN MEDICINE (2015)

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Article Statistics & Probability

MatchIt: Nonparametric Preprocessing for Parametric Causal Inference

Daniel E. Ho et al.

Journal of Statistical Software (2015)

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Article Neurosciences

Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia

Jeannie-Marie S. Leoutsakos et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

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Article Geriatrics & Gerontology

The Association of Neuropsychiatric Symptoms in MCI with Incident Dementia and Alzheimer Disease

Paul B. Rosenberg et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2013)

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Article Mathematical & Computational Biology

The performance of different propensity score methods for estimating marginal hazard ratios

Peter C. Austin

STATISTICS IN MEDICINE (2013)

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Article Clinical Neurology

Historical Changes in the Severity of Dementia and Accompanying Neuropsychiatric Symptoms in Persons Presenting for Evaluation in a Multiracial Urban Dementia Center

Carl I. Cohen et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2012)

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Review Clinical Neurology

The National Alzheimer's Coordinating Center (NACC) database: The uniform data set

Duane L. Beekly et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2007)

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Article Clinical Neurology

Cultural diversity in Alzheimer disease - The interface between biology, belief, and behavior

HC Chui et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2005)

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Article Medicine, General & Internal

Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment - Results from the Cardiovascular Health Study

CG Lyketsos et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)

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Article Geriatrics & Gerontology

Neuropsychiatric symptoms of Alzheimer's disease differ in Chinese and American patients

TW Chow et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2002)

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Article Psychiatry

Mental and behavioral disturbances in dementia: Findings from the Cache County Study on Memory in Aging

CG Lyketsos et al.

AMERICAN JOURNAL OF PSYCHIATRY (2000)

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Racial and ethnic differences in neuropsychiatric symptoms and progression to incident cognitive impairment among community-dwelling participants

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