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APOE and immunity: Research highlights

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Summary: The research indicates that APOE e4 is associated with lower blood CRP levels, particularly within the low range, and both APOE e4 and high CRP levels are linked to smaller hippocampus volumes.

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Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status

Courtney M. Kloske et al.

Summary: Alzheimer's disease (AD) is characterized by cognitive decline and dementia, with the most impactful genetic risk factor being APOE. Research suggests that APOE-ε4 is associated with neuroinflammatory state and AD pathology, while APOE-ε3 may have harmful long-term inflammatory response to pathology.

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Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous APOE e4 Carriers

Qiushan Tao et al.

Summary: This study revealed the interactive effects of plasma CRP and APOE genotype on cognition and AD biomarkers, showing that elevated CRP in carriers of 2 APOE epsilon 4 alleles was associated with lower cognitive scores and increased tau protein levels in CSF. Conversely, elevated CRP in individuals with no APOE epsilon 4 alleles was associated with decreased tau protein levels in CSF. These findings suggest that CRP may play a role in AD neurodegeneration in APOE epsilon 4 carriers and could potentially be targeted for drug interventions.

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