The multifactorial etiology of cognitive deficits in epilepsy and the neuropathology of mesial temporal lobe epilepsy beyond hyperphosphorylated tau

Article Clinical Neurology

Does Alzheimer's disease with mesial temporal lobe epilepsy represent a distinct disease subtype?

Ifrah Zawar et al.

Summary: Patients with Alzheimer's disease (AD) and mesial temporal lobe epilepsy (MTLE) may represent a distinct subtype of AD. AD and MTLE share histopathological features and involve overlapping neuronal and cortical networks. Hyper-phosphorylated tau (pTau) increases neuronal excitability and provokes seizures, while neuronal excitability increases pTau. The pTau burden in mesial temporal lobe predicts cognitive deficits in AD and MTLE.

ALZHEIMERS & DEMENTIA (2023)

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Article Clinical Neurology

Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy

Annika Reimers et al.

Summary: In this study, extensive neuropathological examinations were conducted on patients showing cognitive decline after epilepsy surgery. The results indicated the presence of secondary neurodegenerative diseases or independent neurodegenerative alterations in addition to typical pathologies. This suggests the need for a multicenter collection of such cases to identify presurgical biomarkers for better surgical decision-making.

ANNALS OF NEUROLOGY (2023)

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Review Neurosciences

Neuropsychological Evaluations in Limbic Encephalitis

Juri-Alexander Witt et al.

Summary: Limbic encephalitis (LE) can lead to episodic long-term memory dysfunction, executive deficits, and affective disorders. Evidence-based neuropsychological assessments are essential for the diagnostic workup, treatment decisions, and disease monitoring of patients with suspected or diagnosed LE.

BRAIN SCIENCES (2021)

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Editorial Material Pharmacology & Pharmacy