☆ 4.6 Article

Spatial transcriptomics combined with single-cell RNA-sequencing unravels the complex inflammatory cell network in atopic dermatitis

ALLERGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Allergy

Single-cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasis

Bowen Zhang et al.

Summary: Single-cell analysis of atopic dermatitis and psoriasis patients revealed disease-specific T cell clusters and identified cell type-specific gene expression associated with inflammation signatures and disease severity. The study shed light on the complexity of inflammatory responses and provided valuable insights for further investigation and therapeutic approaches for these chronic inflammatory skin diseases.

ALLERGY (2023)

添加到收藏夹

Article Cell Biology

NF-κB perturbation reveals unique immunomodulatory functions in Prx1+ fibroblasts that promote development of atopic dermatitis

Kang Ko et al.

Summary: The study reveals the important role of a specific subpopulation of Prx1(+) fibroblasts in immune regulation of the skin. Disruption of the Ikkb-NF-kappa B pathway in these fibroblasts triggers skin inflammation and results in overexpression of CCL11, leading to eosinophil infiltration and T(H)2 immune response, resembling human atopic dermatitis. Monoclonal antibody treatment targeting CCL11 shows promising efficacy in a mouse model.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Cell Biology

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

Diana Tavares-Ferreira et al.

Summary: Nociceptors, specialized sensory neurons, play a crucial role in detecting and generating pain signals. This study used spatial transcriptomics to characterize the transcriptomes of human nociceptors, identifying different clusters and potential drug targets in the human dorsal root ganglia (DRG). Comparison with mouse sensory neuron transcriptomes and nonhuman primate DRG neuronal subtypes revealed conserved gene expression patterns but also species-specific differences. Sex differences in DRG subpopulation transcriptomes were also identified. This comprehensive spatial characterization of human nociceptors has significant implications for the development of improved treatments for pain disorders.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Allergy

Environment-dependent alterations of immune mediators in urban and rural south African children with atopic dermatitis

Nonhlanhla Lunjani et al.

Summary: This study found that children with AD had elevated levels of certain immune markers regardless of their location, while children living in rural areas had higher levels of various cytokines compared to urban children. Factors such as early life nutrition, medications, and environmental exposures were associated with differences in circulating cytokine levels in children with AD.

ALLERGY (2022)

添加到收藏夹

Article Allergy

Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

Natalia Alkon et al.

Summary: This study investigates the phenotypic and molecular features of cutaneous innate lymphoid cells (ILCs) to better understand the biological role of these cells. The findings demonstrate the flexibility of the skin immune system, with ILCs in diseased skin expressing genes characteristic of different immune types. This suggests that the skin immune system can adjust its function to adapt to the environment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Developmental cell programs are co-opted in inflammatory skin disease

Gary Reynolds et al.

Summary: The skin establishes a complex cellular network early in embryonic development to provide biophysical and immunological protection. The study found an enrichment of innate immune cells in skin during the first trimester, as well as clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. Additionally, a reemergence of prenatal vascular endothelial cell and macrophage cellular programs was observed in atopic dermatitis and psoriasis lesional skin.

SCIENCE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Histamine Increases Th2 Cytokine-Induced CCL18 Expression in Human M2 Macrophages

Susanne Mommert et al.

Summary: The study investigated the role of histamine in CCL18 production in human monocyte-derived M2 macrophages, finding that IL-10 upregulated H2R and increased CCL18 expression through H2R stimulation. This effect was similar in cells from atopic dermatitis patients compared to healthy controls.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Allergy

Advances in atopic dermatitis in 2019-2020: Endotypes from skin barrier, ethnicity, properties of antigen, cytokine profiles, microbiome, and engagement of immune cells

Takashi Nomura et al.

Summary: Key research advances in atopic dermatitis reveal the complexity of its endotypes, including traditional TH2-dominant type and an axis of cytokines commonly seen in Asian individuals. Innate lymphoid cells play a critical role in AD development and heterogeneity. Stratification based on endotypes may lead to customized therapeutic strategies in the future.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin

Ian C. Boothby et al.

Summary: Early-life inflammation can lead to lasting changes in the immune system that confer disease protection or susceptibility. In a mouse skin study, neonatal inflammation was found to cause dysregulation of subcutaneous tissue, with the accumulation of T(H)2 cells and interactions with fibroblasts. This study also identified a T(H)2 cell niche in skin and disease-associated fibroblast populations, suggesting a mechanism of immunological priming through early-life inflammation.

NATURE (2021)

添加到收藏夹

Article Immunology

Spontaneously Resolved Atopic Dermatitis Shows Melanocyte and Immune Cell Activation Distinct From Healthy Control Skin

Katharina Rindler et al.

Summary: The study found that the overall cell composition and proteomic profiles of spontaneously healed atopic dermatitis (AD) patients were comparable to healthy controls, without the upregulation of typical AD activity markers. Melanocytes and conventional T-cells in spontaneously healed AD skin may play a role in providing a specific regulatory environment.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Allergy

Biologics for Treatment of Atopic Dermatitis: Current Status and Future Prospect

Thanaporn Ratchataswan et al.

Summary: Atopic dermatitis is a common inflammatory skin disease characterized by intense itching and recurrent eczema lesions. The development of targeted biologic therapies, such as Dupilumab, is highly desirable for the treatment of moderate-to-severe forms of AD.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

添加到收藏夹

Article Allergy

Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis

Arturo O. Rinaldi et al.

Summary: This study successfully established a method to directly assess the in vivo status of the epithelial barrier using electrical impedance spectroscopy, demonstrating its usefulness in patients with atopic dermatitis. Electrical impedance spectroscopy showed a significant negative correlation with transepidermal water loss, and a higher sensitivity in discriminating between lesional and non-lesional skin in patients with atopic dermatitis.

ALLERGY (2021)

添加到收藏夹

Review Allergy

Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council

Yael Renert-Yuval et al.

Summary: Atopic dermatitis is a common yet complex skin disease with different phenotypes among patient populations, making therapeutic response variable. Biomarkers have the potential to improve precision medicine in AD, but further research is needed due to the complexity of the disease.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Review Allergy

A new era of atopic eczema research: Advances and highlights

Claudia Hulpusch et al.

Summary: Atopic eczema is an inflammatory skin disease influenced by genetic, immunological, and environmental factors. It is characterized by skin barrier disruption, abnormal immune response, and the impact of external factors. Prevention and appropriate treatment are crucial, and while new therapeutic options have emerged, individualized precision medicine approaches are still necessary.

ALLERGY (2021)

添加到收藏夹

Article Oncology

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

Colin Hutton et al.

Summary: This study used mass cytometry to analyze the stromal composition in murine tissues and tumors, revealing extensive stromal heterogeneity and coordinated relationships between mesenchymal and immune cell subsets in pancreatic ductal adenocarcinoma. The research identified two stable and functionally distinct pancreatic fibroblast lineages marked by CD105 expression, with CD105-positive fibroblasts promoting tumor growth and CD105-negative fibroblasts suppressing tumors, dependent on adaptive immunity. These findings highlight the importance of mesenchymal and immune cell interactions in restricting tumor growth.

CANCER CELL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer

Emma Probst Brandum et al.

Summary: Chemotactic cytokines-chemokines play an important role in the development of chronic inflammatory diseases, with CCR7 and DCs playing key roles in diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis, and also being potential targets in cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Medicine, General & Internal

Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double- blind, randomised controlled phase 3 trials

Emma Guttman-Yassky et al.

Summary: The clinical trials demonstrated that Upadacitinib may be an effective treatment option for moderate-to-severe atopic dermatitis, with a significant improvement in symptoms for most patients within 16 weeks, and both dosages were well tolerated.

LANCET (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Embryo-scale, single-cell spatial transcriptomics

Sanjay R. Srivatsan et al.

Summary: The study introduces a method called sci-Space, which allows for spatial heterogeneity analysis at larger scales while retaining single-cell resolution. By applying this method to developing mouse embryos, the researchers identified thousands of genes exhibiting anatomically patterned expression and leveraged spatial information to annotate cellular subtypes. The results show substantial variation in spatial patterning among cell types and reveal correlations between pseudotime and the migratory patterns of differentiating neurons.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Cheng-Cheng Deng et al.

Summary: This study examined fibroblast heterogeneity in keloid, a representative of fibrotic skin diseases, using single-cell RNA-seq. The results revealed that keloid fibroblasts could be divided into 4 subpopulations, with an increased percentage of mesenchymal fibroblasts playing a crucial role in collagen overexpression. This increased mesenchymal fibroblast subpopulation was also found in another fibrotic skin disease, scleroderma, suggesting a broad mechanism for skin fibrosis.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Immunology

Fibroblasts as immune regulators in infection, inflammation and cancer

Sarah Davidson et al.

Summary: In different tissues and diseases, fibroblasts play a crucial role in regulating local immune responses by modulating inflammatory or immunosuppressive activities. Their diverse immunological properties highlight the importance of tissue context in determining fibroblast-immune cell interactions.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Article Dermatology

The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature

Ana B. Pavel et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

添加到收藏夹

Article Allergy

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

Helen He et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

添加到收藏夹

Article Allergy

Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type-specific immune regulation in atopic dermatitis

Thomas B. Rojahn et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders

Barbara Russo et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics

Simon Cabello-Aguilar et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma

Andrew L. Ji et al.

CELL (2020)

添加到收藏夹

Article Medicine, General & Internal

Atopic dermatitis

Sinéad M Langan et al.

LANCET (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells

Yuko Yoshida et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

添加到收藏夹

Article Immunology

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies

Travis K. Hughes et al.

IMMUNITY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

Young Eun Choi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Allergy

Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

Emma Guttman-Yassky et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Skin-Associated B Cells in Health and Inflammation

Gudrun F. Debes et al.

JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Article Dermatology

The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease

Patrick M. Brunner et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

添加到收藏夹

Article Immunology

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells

Christopher Andrew Tibbitt et al.

IMMUNITY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Atopic Eczema: Genetic Analysis of COL6A5, COL8A1, and COL10A1 in Mediterranean Populations

Claudia Strafella et al.

BIOMED RESEARCH INTERNATIONAL (2019)

添加到收藏夹

Article Allergy

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients

Patrick M. Brunner et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2019)

添加到收藏夹

Article Allergy

Epidemiology of atopic dermatitis in adults: Results from an international survey

S. Barbarot et al.

ALLERGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

Chiraz Atri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Cell Biology

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

Ting Xie et al.

CELL REPORTS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

James Kinchen et al.

CELL (2018)

添加到收藏夹

Article Allergy

Relations between epidermal barrier dysregulation and Staphylococcus species-dominated microbiome dysbiosis in patients with atopic dermatitis

Can Altunbulakli et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Type 2 immunity in tissue repair and fibrosis

Richard L. Gieseck et al.

NATURE REVIEWS IMMUNOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins

Patrick M. Brunner et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Allergy

Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin

Hitokazu Esaki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

添加到收藏夹

Review Cell Biology

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

Mark A. Hauser et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

添加到收藏夹

Article Medicine, General & Internal

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

E. L. Simpson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Article Allergy

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications

Mayte Suarez-Farinas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

添加到收藏夹

Article Immunology

Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

Yohei Natsuaki et al.

NATURE IMMUNOLOGY (2014)

添加到收藏夹

Article Immunology

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

Qian Chai et al.

IMMUNITY (2013)

添加到收藏夹

Article Immunology

Rapamycin unbalances the polarization of human macrophages to M1

Alessia Mercalli et al.

IMMUNOLOGY (2013)

添加到收藏夹

Review Dermatology

Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three-item severity score

A. P. Oranje et al.

BRITISH JOURNAL OF DERMATOLOGY (2007)

添加到收藏夹

Article Medicine, General & Internal

Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys

M. Innes Asher et al.

LANCET (2006)

添加到收藏夹

Article Dermatology

Tenascin-C is upregulated in the skin lesions of patients with atopic dermatitis

K Ogawa et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.