☆ 4.6 Letter

In vitro supporting diagnostic tools in plant-food allergy

ALLERGY (2023)

Ara h 2-Specific IgE Presence Rather Than Its Function Is the Best Predictor of Mast Cell Activation in Children

Chen Ji et al.

Summary: This study found that Arah2-sIgE levels and Ara h 2/total IgE ratios are important factors in determining clinical reactions to peanut allergy, and that most children sensitized to Ara h 2 are peanut-allergic. Specific activity and Arah2-sIgE titers are the major determinants of mast cell response to Ara h 2.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2023)

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Article Biochemistry & Molecular Biology

Basophil Activation Test Utility as a Diagnostic Tool in LTP Allergy

Jose A. Canas et al.

Summary: Plant-food allergy, triggered by nonspecific lipid transfer proteins (nsLTPs), is a growing problem. The basophil activation test (BAT), which identifies specific IgE related to the allergic response, can be used as a diagnostic tool for precise diagnosis of LTP-allergic patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Allergy

Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice

Alexandra F. Santos et al.

Summary: The basophil activation test (BAT) measures the degree of degranulation of basophils following stimulation with allergen, and it can be used as a more specific diagnostic tool for allergic diseases. Clinical application of BAT requires clinical validation, quality assurance, and efforts are ongoing to establish a platform for laboratories to ensure reproducibility and reliability of results.

ALLERGY (2021)

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Article Allergy