4.7 Letter

Letter: Post- -COVID--19 disorders of gut--brain interaction (DGBI)--Just post--infectious or a multi--faceted entity?

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Article Gastroenterology & Hepatology

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Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.

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Cameron K. Ormiston et al.

Summary: Postural orthostatic tachycardia syndrome (POTS) is a complex multisystem disorder characterized by orthostatic intolerance and tachycardia that may be triggered by viral infection. Recent reports indicate that a significant number of COVID-19 survivors develop POTS or POTS-like symptoms within a few months of infection. The pathophysiological mechanisms of post-COVID-19 POTS are not well understood, but hypotheses include autoimmunity, autonomic dysfunction, and central nervous system invasion by the SARS-CoV-2 virus. Practitioners should actively assess POTS in patients with post-acute COVID-19 symptoms and consider lifestyle modifications and medication for treatment.

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Summary: This study conducted a systematic review and meta-analysis to investigate the frequency of gastrointestinal (GI) manifestations in long COVID patients. The results showed that 12% of patients after COVID-19 and 22% of long COVID patients experienced GI symptoms. The most common GI symptoms in long COVID were loss of appetite, dyspepsia, irritable bowel syndrome, loss of taste, and abdominal pain. The study's limitations include significant heterogeneity and a small number of included studies.

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

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