期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 34, 页码 10802-10805出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b06770
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资金
- Janssen Research & Development LLC
- NSF [CHE-1565983]
- National Science Foundation [DGE-1148900]
- Ruth L. Kirschtein NRSA Fellowship [GM108291]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1565983] Funding Source: National Science Foundation
The copper-catalyzed H-F insertion into alpha-diazocarbonyl compounds is described using potassium fluoride (KF) and hexafluoroisopropanol. Access to complex alpha-fluorocarbonyl derivatives is achieved under mild conditions, and the method is readily adapted to radiofluorination with [F-18]KF. This late-stage strategy provides an attractive route to F-18-labeled biomolecules.
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