4.7 Review

Pleiotropic and multi-systemic actions of physical exercise on PGC-1a signaling during the aging process

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Geriatrics & Gerontology

Muscle PGC-1α modulates hepatic mitophagy regulation during aging

Natascha Masselkhi Christensen et al.

Summary: This study found that aging is associated with changes in oxidative capacity, autophagy, and mitophagy in the liver. Muscle PGC-1 alpha may regulate these processes through myokines. However, muscle-specific PGC-1 alpha knockout has no effect on autophagy and mitophagy capacity in the liver.

EXPERIMENTAL GERONTOLOGY (2023)

Review Public, Environmental & Occupational Health

Active Aging and Public Health: Evidence, Implications, and Opportunities

Shilpa Dogra et al.

Summary: This article reviews the beneficial outcomes of active aging, including improved physical function, cognitive function, mental health, social health, and sleep. It emphasizes the critical role of age-friendly environments in facilitating active aging and explores emerging opportunities related to social engagement and technology-enabled mobility.

ANNUAL REVIEW OF PUBLIC HEALTH (2022)

Article Geriatrics & Gerontology

Effects of different types of exercise training on angiogenic responses in the left ventricular muscle of aged rats

Hyo-Seong Yeo et al.

Summary: The study evaluated angiogenic responses and aerobic capacity in aged rats according to different exercise types (aerobic, resistance, combined). The results showed that regular exercise training, regardless of type, may improve cardiovascular function by inducing angiogenic responses in the aged myocardium, with aerobic exercise being potentially the most effective.

EXPERIMENTAL GERONTOLOGY (2022)

Review Andrology

The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes

Teresa Vezza et al.

Summary: This review explores the molecular mechanisms of mitochondrial fusion and fission processes, their role in type 2 diabetes, and the therapeutic potential of targeting mitochondrial dynamics in this complex metabolic disorder.

WORLD JOURNAL OF MENS HEALTH (2022)

Article Physiology

Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules

Naser Mahdavi et al.

Summary: Mild to moderate-intensity endurance exercise training combined with hind-limb blood flow restriction improves heart performance in aging rats through ameliorating apoptosis, recovering redox balance, improving the longevity factor klotho, and increasing the key energy metabolism regulator PGC1-alpha.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2022)

Article Multidisciplinary Sciences

Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise

Jin-Ho Koh et al.

Summary: Resistance exercise training (RET) is effective in counteracting sarcopenia, frailty, and metabolic disorders. The increase in PGC-1 alpha 4 expression induced by RET promotes muscle hypertrophy and enhances glycolysis, providing a rapid supply of ATP for muscle contractions. The findings also suggest a mechanistic link between RET and improved glucose metabolism.

NATURE COMMUNICATIONS (2022)

Article Geriatrics & Gerontology

Impact of high-intensity interval training with or without l-citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults

Vincent Marcangeli et al.

Summary: The study found that high-intensity interval training (HIIT) is beneficial for obese older adults, improving muscle function, functional capacities, body composition, and waist circumference. Adding citrulline (CIT) further enhances muscle strength and significantly reduces fat mass. HIIT also increases markers of mitochondrial biogenesis, fusion, and mitophagy.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2022)

Review Cell Biology

Pleiotropic effects of mitochondria in aging

Tanes Lima et al.

Summary: This review examines how mitochondrial stress pathways affect cellular and systemic homeostasis during aging, and discusses the roles of signaling pathways involved in regulating these pathways. The review also highlights how mitochondrial failure can result in heteroplasmy and deregulation of key metabolites.

NATURE AGING (2022)

Article Immunology

Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis

Arianna Bianchi et al.

Summary: Moderate exercise can effectively reprogram pre-established inflammatory and metabolic pathologies in aging with the benefit of prevention of disease.

JOURNAL OF IMMUNOLOGY (2021)

Article Neurosciences

Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis

Lars Karlsson et al.

Summary: Physical exercise can improve age-dependent cognitive decline by restoring neurogenesis, with myokines serving as a link between muscle and brain communication. However, chronic muscular overexpression of PGC-1 alpha does not translate into exercise-induced effects on hippocampal neurogenesis, despite differences in serum composition. This suggests that activation of PGC-1 alpha in skeletal muscle alone is not enough to mimic exercise-induced effects or prevent neurogenesis decline with aging.

MOLECULAR NEUROBIOLOGY (2021)

Review Physiology

Impact of paternal exercise on physiological systems in the offspring

Ivo Vieira de Sousa Neto et al.

Summary: Numerous studies have shown that paternal exercise can influence future generations through epigenetic changes in sperm. The effects of paternal exercise on offspring's physiological systems have not been extensively explored, but it is known that non-coding RNA and DNA methylation play major roles in transmitting this information. Fathers who engage in resistance and treadmill exercises may provide protective effects on fetal development and placental inflammation.

ACTA PHYSIOLOGICA (2021)

Article Cell Biology

Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue

Ana Paula Azevedo Macedo et al.

Summary: The redistribution of body fat induced by aging is associated with changes in mitochondria, leading to metabolic and inflammatory issues. Studying this process is crucial for mitigating the health problems associated with aging.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Article Geriatrics & Gerontology

Eight Weeks of High-Intensity Interval Static Strength Training Improves Skeletal Muscle Atrophy and Motor Function in Aged Rats via the PGC-1α/FNDC5/UCP1 Pathway

Yijie Liu et al.

Summary: The study found that static strength training helps increase muscle fiber volume in rats, reduce body weight and fat accumulation, and prevent muscle atrophy and improve motor function through the PGC-1 alpha/FNDC5/UCP1 signaling pathway.

CLINICAL INTERVENTIONS IN AGING (2021)

Article Biochemistry & Molecular Biology

Alterations in mitochondrial biogenesis and respiratory activity, inflammation of the senescence-associated secretory phenotype, and lipolysis in the perirenal fat and liver of rats following lifelong exercise and detraining

Lei Sun et al.

Summary: The study found that lifelong exercise significantly improved mitochondrial function, SASP-associated inflammation, and lipolysis, inhibiting inflammatory regulation pathways. Detraining, on the other hand, activated the NF-kappa B signaling pathway and elevated serum high-sensitivity C-reactive protein levels.

FASEB JOURNAL (2021)

Article Physiology

Aging reduces succinate dehydrogenase activity in rat type IIx/IIb diaphragm muscle fibers

Matthew J. Fogarty et al.

JOURNAL OF APPLIED PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Proteomic changes in skeletal muscle of aged rats in response to resistance training

Ivo Vieira de Sousa Neto et al.

CELL BIOCHEMISTRY AND FUNCTION (2020)

Article Cell Biology

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Yasmine J. Liu et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

Article Endocrinology & Metabolism

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

Melissa Leveille et al.

MOLECULAR METABOLISM (2020)

Review Cell Biology

PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

Sergio Rius-Perez et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Article Geriatrics & Gerontology

The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men

Babak Hooshmand-Moghadam et al.

EXPERIMENTAL GERONTOLOGY (2020)

Article Geriatrics & Gerontology

Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells

Su-Bin Kim et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

Review Biochemistry & Molecular Biology

Exercise effects on physiological function during aging

Zsolt Radak et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats

Anand Thirupathi et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

Article Multidisciplinary Sciences

PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

Aurele Besse-Patin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Endocrinology & Metabolism

PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training

Jens Frey Halling et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Review Biochemistry & Molecular Biology

Causal roles of mitochondrial dynamics in longevity and healthy aging

Arpit Sharma et al.

EMBO REPORTS (2019)

Article Multidisciplinary Sciences

An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

A. K. Ziegler et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo

Dongwook Yeo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Physiology

Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium

Ross Summer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

Article Endocrinology & Metabolism

Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation

Chang-Yun Woo et al.

DIABETES & METABOLISM JOURNAL (2019)

Article Multidisciplinary Sciences

Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue

Adam C. Lehnig et al.

ISCIENCE (2019)

Article Geriatrics & Gerontology

Effect of Aging on Mitochondrial Energetics in the Human Atria

Larisa Emelyanova et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

Article Physiology

Altered expression of hepatic beta-adrenergic receptors in aging rats: implications for age-related metabolic dysfunction in liver

Yun Shi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

PGC-1: The Energetic Regulator in Cardiac Metabolism

Wencheng Di et al.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2018)

Article Physiology

Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle

Heather N. Carter et al.

JOURNAL OF APPLIED PHYSIOLOGY (2018)

Review Cell Biology

Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics

Justyna Janikiewicz et al.

CELL DEATH & DISEASE (2018)

Review Geriatrics & Gerontology

Age-related changes in skeletal muscle: changes to life-style as a therapy

Rachel McCormick et al.

BIOGERONTOLOGY (2018)

Article Medicine, Research & Experimental

Aerobic Exercise Training Alleviates Renal Injury by Interfering with Mitochondrial Function in Type-1 Diabetic Mice

Lin-Xia Tang et al.

MEDICAL SCIENCE MONITOR (2018)

Article Geriatrics & Gerontology

Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice

Aaron M. Gusdon et al.

EXPERIMENTAL GERONTOLOGY (2017)

Article Geriatrics & Gerontology

PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver

Caroline M. Kristensen et al.

EXPERIMENTAL GERONTOLOGY (2017)

Article Urology & Nephrology

PGC-1α Protects from Notch-Induced Kidney Fibrosis Development

Seung Hyeok Han et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Cell Biology

Rodent models in Down syndrome research: impact and future opportunities

Yann Herault et al.

DISEASE MODELS & MECHANISMS (2017)

Article Geriatrics & Gerontology

Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/PGC-1α Complex in Aged Rats

Ivan J. Vechetti-Junior et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

Article Medicine, General & Internal

Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1α Expression Levels in Rats of Different Age

Chi-Chang Huang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2016)

Article Multidisciplinary Sciences

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

Mei T. Tran et al.

NATURE (2016)

Article Multidisciplinary Sciences

PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model

Loukia Katsouri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Oncology

Reprogramming of energy metabolism as a driver of aging

Zhaoyang Feng et al.

ONCOTARGET (2016)

Article Cell Biology

PGC-1α modulates denervation-induced mitophagy in skeletal muscle

Anna Vainshtein et al.

SKELETAL MUSCLE (2015)

Article Multidisciplinary Sciences

PGC-1α Promoter Methylation in Parkinson's Disease

Xiaomin Su et al.

PLOS ONE (2015)

Article Endocrinology & Metabolism

Loss of Pgc-1 alpha expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

Sarah Sczelecki et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

Article Biochemistry & Molecular Biology

Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

Luis Rato et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2014)

Review Physiology

Mitochondrial function/dysfunction in white adipose tissue

Sihem Boudina et al.

EXPERIMENTAL PHYSIOLOGY (2014)

Article Endocrinology & Metabolism

Skeletal Muscle Mitochondria in the Elderly: Effects of Physical Fitness and Exercise Training

Nicholas T. Broskey et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Geriatrics & Gerontology

Markers of Human Skeletal Muscle Mitochondrial Biogenesis and Quality Control: Effects of Age and Aerobic Exercise Training

Adam R. Konopka et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

Editorial Material Multidisciplinary Sciences

Mitochondria impact brain function and cognition

Martin Picard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Endocrinology & Metabolism

Genetic models of PGC-1 and glucose metabolism and homeostasis

Glenn C. Rowe et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2014)

Review Biotechnology & Applied Microbiology

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

Dimitry A. Chistiakov et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

Katia Aquilano et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Endocrinology & Metabolism

PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner

Serge Summermatter et al.

DIABETES (2013)

Article Geriatrics & Gerontology

Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: Role of PGC-1α

Chounghun Kang et al.

EXPERIMENTAL GERONTOLOGY (2013)

Article Physiology

Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training

Erika Koltai et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

Jorge L. Ruas et al.

Article Biochemistry & Molecular Biology

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse

Lloye M. Dillon et al.

HUMAN MOLECULAR GENETICS (2012)

Review Biochemistry & Molecular Biology

The role of PGC-1 coactivators in aging skeletal muscle and heart

Lloye M. Dillon et al.

IUBMB LIFE (2012)

Article Neurosciences

Brain structural complexity and life course cognitive change

Nazahah Mustafa et al.

NEUROIMAGE (2012)

Article Cell Biology

Age-Associated Molecular Changes in the Kidney in Aged Mice

Ji Hee Lim et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)

Article Multidisciplinary Sciences

The Drosophila PGC-1α Homolog spargel Modulates the Physiological Effects of Endurance Exercise

Martin J. Tinkerhess et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

Aiwu Cheng et al.

NATURE COMMUNICATIONS (2012)

Article Nutrition & Dietetics

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

Pablo J. Fernandez-Marcos et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)

Review Biochemistry & Molecular Biology

Autophagy and Aging

David C. Rubinsztein et al.

Editorial Material Cell Biology

A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life

Yi Zhou et al.

CELL METABOLISM (2011)

Review Cardiac & Cardiovascular Systems

The PGC-1 cascade as a therapeutic target for heart failure

Joel Schilling et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

Article Multidisciplinary Sciences

Telomere dysfunction induces metabolic and mitochondrial compromise

Erguen Sahin et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes

Min Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Editorial Material Cell Biology

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

Arnold Y. Seo et al.

JOURNAL OF CELL SCIENCE (2010)

Review Biochemistry & Molecular Biology

PGC-1 alpha in aging and anti-aging interventions

Rozalyn Anderson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Article Neurosciences

Exercise and adrenaline increase PGC-1α mRNA expression in rat adipose tissue

Lindsey N. Sutherland et al.

JOURNAL OF PHYSIOLOGY-LONDON (2009)

Review Cell Biology

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

John Papaconstantinou

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

Article Endocrinology & Metabolism

Endurance Exercise as a Countermeasure for Aging

Ian R. Lanza et al.

DIABETES (2008)

Article Multidisciplinary Sciences

Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Cheol Soo Choi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals

Christoph Handschin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKα

Wan Qiang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2007)

Article Endocrinology & Metabolism

Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes

Nikolaos P. Kadoglou et al.

DIABETES CARE (2007)

Article Education, Scientific Disciplines

PGC-1α:: a key regulator of energy metabolism

Huiyun Liang et al.

ADVANCES IN PHYSIOLOGY EDUCATION (2006)

Article Multidisciplinary Sciences

PGC-1α a protects skeletal muscle from atrophy by suppressing Fox03 action and atrophy-specific gene transcription

Marco Sandri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Atorvastatin prevents peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells

A Planavila et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2005)

Article Cardiac & Cardiovascular Systems

PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells

I Valle et al.

CARDIOVASCULAR RESEARCH (2005)

Article Neurosciences

β2-agonist administration reverses muscle wasting and improves muscle function in aged rats

JG Ryall et al.

JOURNAL OF PHYSIOLOGY-LONDON (2004)

Article Endocrinology & Metabolism

Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response

K Feingold et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

Review Physiology

Muscle biopsy and muscle fiber hypercontraction: a brief review

SM Roth et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2000)