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Long-term human spaceflight and inflammaging: Does it promote aging?

AGEING RESEARCH REVIEWS (2023)

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Review Cardiac & Cardiovascular Systems

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NATURE REVIEWS CARDIOLOGY (2018)

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Inflammaging: a new immune-metabolic viewpoint for age-related diseases

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Sarcolab pilot study into skeletal muscle's adaptation to long-term spaceflight

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Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces

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MICROBIOME (2018)

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Review Medicine, General & Internal

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

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FRONTIERS IN MEDICINE (2018)

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Gut microbiota changes in the extreme decades of human life: a focus on centenarians

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CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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NEUROPSYCHOPHARMACOLOGY (2017)

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Myosin content of single muscle fibers following short-term disuse and active recovery in young and old healthy men

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Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Effect of Oxidative Stress on Cardiovascular System in Response to Gravity

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The effect of spaceflight and microgravity on the human brain

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Inflammaging and human longevity in the omics era

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MECHANISMS OF AGEING AND DEVELOPMENT (2017)

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Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI

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Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500

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MICROBIOME (2017)

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Preparing for the crewed Mars journey: microbiota dynamics in the confined Mars500 habitat during simulated Mars flight and landing

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MICROBIOME (2017)

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Latent virus reactivation in astronauts on the international space station

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Spaceflight-induced neuroplasticity in humans as measured by MRI: what do we know so far?

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Towards human exploration of space: the THESEUS review series on muscle and bone research priorities

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Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial

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Increased core body temperature in astronauts during long-duration space missions

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The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

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Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts

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The impact of microgravity on bone in humans

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Gut Microbiota and Extreme Longevity

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Effects of short-term exposure to head-down tilt on cerebral hemodynamics: a prospective evaluation of a spaceflight analog using phase-contrast MRI

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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

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Signals from the gut microbiota to distant organs in physiology and disease

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Linking the Microoiota, Chronic Disease, anc the Immune System

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Circadian misalignment affects sleep and medication use before and during spaceflight

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DAMPs as mediators of sterile inflammation in aging-related pathologies

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Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

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Spaceflight alters expression of microRNA during T-cell activation

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Functional changes in neutrophils and psychoneuroendocrine responses during 105 days of confinement

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Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight

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Neutrophil ageing is regulated by the microbiome

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Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System

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Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for inflamm- aging

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Involvement of MicroRNAs in the Regulation of Muscle Wasting during Catabolic Conditions

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Trim32 reduces PI3K-Akt-Fox0 signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation

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Plasma Cytokine Concentrations Indicate That In Vivo Hormonal Regulation of Immunity Is Altered During Long-Duration Spaceflight

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Space Radiation Risks for Astronauts on Multiple International Space Station Missions

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AGE (2013)

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MicroRNAs linking inflamm-aging, cellular senescence and cancer

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Optic Disc Edema in an Astronaut After Repeat Long-Duration Space Flight

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Correction: Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

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INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2012)

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The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity

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Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age

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Muscles, exercise and obesity: skeletal muscle as a secretory organ

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Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

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MECHANISMS OF AGEING AND DEVELOPMENT (2012)

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Charting the NF-κB Pathway Interactome Map

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PLOS ONE (2012)

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Adaptation of Mouse Skeletal Muscle to Long-Term Microgravity in the MDS Mission

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PLOS ONE (2012)

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Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

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AGING CELL (2011)

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Adrenocortical and Immune Responses Following Short- and Long-Duration Spaceflight

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AVIATION SPACE AND ENVIRONMENTAL MEDICINE (2011)

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Disuse of the musculo-skeletal system in space and on earth

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EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2011)

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Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury

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JOURNAL OF INFLAMMATION-LONDON (2011)

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Redox homeostasis, oxidative stress and disuse muscle atrophy

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LANCET (2011)

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Optic Disc Edema, Globe Flattening, Choroidal Folds, and Hyperopic Shifts Observed in Astronauts after Long-duration Space Flight

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OPHTHALMOLOGY (2011)

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The anatomical arrangement of muscle and tendon enhances limb versatility and locomotor performance

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PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

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Mortality Among U.S. Astronauts: 1980-2009

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AVIATION SPACE AND ENVIRONMENTAL MEDICINE (2010)

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Sarcopenia: characteristics, mechanisms and functional significance

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BRITISH MEDICAL BULLETIN (2010)

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Vibration as an exercise modality: how it may work, and what its potential might be

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EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2010)

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Space, Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini-Review

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GERONTOLOGY (2010)

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Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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NATURE (2010)

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Review Immunology

CD56 negative NK cells: origin, function, and role in chronic viral disease

Niklas K. Bjorkstrom et al.

TRENDS IN IMMUNOLOGY (2010)

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Reduction in proximal femoral strength due to long-duration spaceflight

J. H. Keyak et al.

BONE (2009)

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Article Physiology

Differential atrophy of the lower-limb musculature during prolonged bed-rest

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EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2009)

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Effects of spaceflight on murine skeletal muscle gene expression

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JOURNAL OF APPLIED PHYSIOLOGY (2009)

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Effect of 5 weeks horizontal bed rest on human muscle thickness and architecture of weight bearing and non-weight bearing muscles

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EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2008)

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Article Geriatrics & Gerontology

Neuroendocrine features in extreme longevity

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EXPERIMENTAL GERONTOLOGY (2008)

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Article Geriatrics & Gerontology

Understanding the mechanisms of senile osteoporosis: New facts for a major geriatric syndrome

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JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2008)

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Influence of f-MLP, ACTH(1-24) and CRH on in vitro Chemotaxis of Monocytes from Centenarians

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NEUROIMMUNOMODULATION (2008)

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Review Endocrinology & Metabolism

Immunosenescence and Immunogenetics of Human Longevity

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Time course of muscular, neural and tendinous adaptations to 23 day unilateral lower-limb suspension in young men

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JOURNAL OF PHYSIOLOGY-LONDON (2007)

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Article Physiology

Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station

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JOURNAL OF APPLIED PHYSIOLOGY (2007)

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Article Cell Biology

Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans

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MECHANISMS OF AGEING AND DEVELOPMENT (2007)

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Review Physiology

From space to Earth: advances in human physiology from 20 years of bed rest studies (1986-2006)

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EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2007)

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Article Cell Biology

Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life

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AGING CELL (2006)

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Article Endocrinology & Metabolism

Muscle atrophy and bone loss after 90 days' bed rest and the effects of flywheel resistive exercise and pamidronate: Results from the LTBR study

J Rittweger et al.

BONE (2005)

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Article Multidisciplinary Sciences

Decline in skeletal muscle mitochondrial function with aging in humans

KR Short et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Cardiac & Cardiovascular Systems

Cardiovascular function and basics of physiology in microgravity

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ACTA CARDIOLOGICA (2005)

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Review Physiology

Inflammatory processes in muscle injury and repair

JG Tidball

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2005)

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Effects of 17-day spaceflight on electrically evoked torque and cross-sectional area of the human triceps surae

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EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2003)

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Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart

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Microgravity as a model of ageing

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CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2003)

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Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts

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LANCET (2000)

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