期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 9, 页码 2921-2924出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b12739
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资金
- Defense Threat Reduction Agency [HDTRA1-14-1-0004]
- College of Science
- Office of the Vice President for Research
The mechanism of action of the manganese -dependent phosphotriesterase from Sphingobium sp. strain TCM1 that is capable of hydrolyzing organophosphate flame retardants was determined. The enzyme was shown to hydrolyze the R-P-enantiorner of O-methyl O-cydohexyl p-nitrophenyl thiophosphate with net inversion of configuration and without the formation of a covalent reaction intermediate. These results demonstrate that the enzyme catalyzes the hydrolysis of substrates by activation of a nucleophilic water molecule for direct attack at the phosphorus center.
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