期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 365, 期 12, 页码 2036-2042出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202300204
关键词
C-H functionalization; aza-annulation; 1; 4-rhodium migration; 3-enynes; benzo[d]sultams
This paper reports the Rh(III)-catalyzed cascade oxidative C-H functionalization/aza-annulation of indole and pyrrole-N-carboxamides with 1,3-enynes involving 1,4-rhodium migration. It provides an approach for the synthesis of imidazo[1,5-a]indol-3(2H)-ones from easily accessible substrates. The compatibility of sulfonamides in this method is also demonstrated, leading to the corresponding benzo[d]sultams.
Rh(III)-catalyzed cascade oxidative C-H functionalization/aza-annulation of indole and pyrrole-N-carboxamides with 1,3-enynes involving 1,4-rhodium migration is disclosed. This [4+1] annulation protocol provides an approach for the synthesis of imidazo[1,5-a]indol-3(2H)-ones from easily accessible substrates. Moreover, sulfonamides are also found to be well compatible in this method, leading to the corresponding benzo[d]sultams. The efficacy of this protocol is highlighted by handy downstream conversions of the dienyl-sultam.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据