Cobalt-Catalyzed Allylic Defluorinative Cross-Electrophile Coupling between 1,1-Difluoroalkyl Halides and α-Trifluoromethyl Styrenes

In this protocol, we apply reductive cobalt catalysis in the allylic defluorinative cross-electrophile coupling reaction between 1,1-difluoroalkyl halides and a-trifluoromethyl styrenes. This reaction features broad substrate scope (39 examples), good tolerance of various functionalities, and circumvention of pregenerating organometallics, offering a general synthetic route to prepare diverse organofluorines incorporating both a gem-difluoroalkene and a gem-difluoroalkane moiety.

Automated summary

In this protocol, reductive cobalt catalysis is used in the allylic defluorinative cross-electrophile coupling reaction between 1,1-difluoroalkyl halides and α-trifluoromethyl styrenes. This reaction shows a broad substrate scope (39 examples), good tolerance of various functionalities, and eliminates the need for pregenerating organometallics, providing a general method for synthesizing diverse organofluorines containing both a gem-difluoroalkene and a gem-difluoroalkane unit.