Chiral Boro-Phosphate Catalyzed Asymmetric Transfer Hydrogenation of 1-Enal Substituted 2-Naphthols: Access to Axially Chiral Styrene-Type Allylalcohols

Herein, we present a chiral boro-phosphate catalyzed atroposelective asymmetric transfer hydrogenation method, leading to a family of axially chiral styrene-type allylalcohols. This dynamic kinetic resolution approach portrays simple procedure, mild conditions and good enantiocontrol (51-95% ee), thus providing an important alternative to assemble the challenging atropisomeric aryl-acyclic alkene scaffolds.

Automated summary

Here, a chiral boro-phosphate catalyst is presented for an atroposelective asymmetric transfer hydrogenation method, allowing the synthesis of axially chiral styrene-type allyl alcohols. This dynamic kinetic resolution approach offers a simple procedure, mild conditions, and good enantiocontrol (51-95% ee), providing an important alternative for constructing challenging atropisomeric aryl-acyclic alkene scaffolds.