期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 365, 期 11, 页码 1801-1805出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202300221
关键词
heterocycle; calcium carbide; copper; amidine; imidazole
This study presents a protocol for synthesizing 2,4,5-substituted imidazole-bearing methyl groups using A3-coupling cyclization with calcium carbide as the acetylene source, reacting with amidines and aldehydes. This methodology is characterized by several features, including the utilization of a solid alkyne source, readily accessible starting materials, and applicability to 34 examples.
Imidazole derivatives are critical building blocks in the synthesis of pharmaceuticals, fluorescent materials, and ligands. Despite the development of many strategies, the reliable synthesis of 2,4,5-substituted imidazoles remains heavily researched. In this study, we present a protocol for synthesizing 2,4,5-substituted imidazole-bearing methyl groups using A3-coupling cyclization with calcium carbide as the acetylene source, reacting with amidines and aldehydes. This methodology is characterized by several features, including the utilization of a solid alkyne source, readily accessible starting materials, and applicability to 34 examples.
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