4.8 Article

A Conformable Ultrasound Patch for Cavitation-Enhanced Transdermal Cosmeceutical Delivery

期刊

ADVANCED MATERIALS
卷 35, 期 23, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202300066

关键词

acoustic cavitation; conformable ultrasound; transdermal drug delivery

向作者/读者索取更多资源

Researchers report a soft ultrasound patch that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis. The patch consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets over larger areas of conformal contact. The system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro, showing its suitability for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.
Increased consumer interest in healthy-looking skin demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. Here, a conformable ultrasound patch (cUSP) that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis in the fluid coupling medium between the patch and the skin is reported. The cUSP consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets (0.8 cm(2), 1 mm deep) over larger areas of conformal contact (20 cm(2)). Multiphysics simulation models, acoustic spectrum analysis, and high-speed videography are used to characterize transducer deflection, acoustic pressure fields, and resulting cavitation bubble dynamics in the coupling medium. The final system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro with a 10 min ultrasound application, demonstrating the suitability of the device for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据