期刊
ADVANCED MATERIALS
卷 35, 期 23, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202300066
关键词
acoustic cavitation; conformable ultrasound; transdermal drug delivery
Researchers report a soft ultrasound patch that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis. The patch consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets over larger areas of conformal contact. The system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro, showing its suitability for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.
Increased consumer interest in healthy-looking skin demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. Here, a conformable ultrasound patch (cUSP) that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis in the fluid coupling medium between the patch and the skin is reported. The cUSP consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets (0.8 cm(2), 1 mm deep) over larger areas of conformal contact (20 cm(2)). Multiphysics simulation models, acoustic spectrum analysis, and high-speed videography are used to characterize transducer deflection, acoustic pressure fields, and resulting cavitation bubble dynamics in the coupling medium. The final system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro with a 10 min ultrasound application, demonstrating the suitability of the device for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.
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