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Article
Immunology
Anastasia du Halgouet et al.
Summary: Tissue repair processes are important for maintaining organ function after mechanical or infection-related damage. Mucosal associated invariant T (MAIT) cells not only possess antibacterial properties but also play a role in tissue repair and promote skin wound healing. In this study, a human-like mouse model was used to investigate the mechanisms behind the tissue repair function of MAIT cells. The results showed that skin MAIT cells already expressed a repair program at steady state and promoted keratinocyte proliferation to accelerate wound healing. MAIT cells migrated to the wound in a T cell receptor-independent but CXCR6 chemokine receptor-dependent manner and secreted Amphiregulin to facilitate wound healing. The expression of the repair function was likely independent of sustained TCR stimulation. Overall, this study provides insights into the mechanisms of MAIT cell wound healing function in the skin.
Article
Multidisciplinary Sciences
Tuo Deng et al.
Nature Communications
(2023)
Article
Chemistry, Multidisciplinary
Yanting Shen et al.
Summary: Injectable fibro-gel, a water-filled network of entangled hydrogel microfibers, has shown great potential in tissue engineering and regenerative medicine due to its injectability, tailorable physicochemical properties, and controlled drug release profiles. Preliminary in vivo tests on a mice excision skin model have demonstrated that the fibro-gel promotes faster wound healing and new tissue regeneration compared to a commercial gel. Moreover, the release of distinct drugs at different rates using a two-layer fibro-gel model further enhances wound healing efficiency.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Meimei Fu et al.
Summary: TE-CMBAs is a special type of bioadhesive dressing for diabetic wound healing. It has excellent properties such as fast gelation, shape adaptability, mechanical strength, tissue adhesiveness, antimicrobial activity, antioxidant activity, biocompatibility, and angiogenetic property. It also has self-healability and on-demand removability, offering effective treatment in the acidic environment of diabetic wounds.
Article
Chemistry, Multidisciplinary
Ruizeng Luo et al.
Summary: An electrogenerative dressing (EGD) is developed by integrating triboelectric nanogenerators with negative-pressure wound therapy (NPWT). EGD converts negative-pressure-induced mechanical deformation into electricity, generating a stable and high-safety endogenous electric field (EF) that promotes epithelial electrotactic response and macrophage phenotype transition. EGD therapy reshapes the weakened wound EF, accelerates wound closure, and advances tissue remodeling with mature epithelium and less scar formation.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Fan Zhao et al.
Summary: Biofilm infection in chronic wounds is common and delays wound healing. This paper describes a highly effective electrical antibiofilm treatment system that uses high-intensity current to debride biofilm and enhance antibiotic delivery. The system reduces bacterial count of MRSA biofilm-infected ex vivo skin wounds and demonstrates in vivo antibiofilm efficacy in a diabetic mouse-based wound infection model. This novel technology provides a quick, safe, and highly efficacious treatment for chronic wound biofilm infections.
ADVANCED MATERIALS
(2023)
Article
Cell Biology
Diefei Liang et al.
Summary: The dysregulation of autophagy, as well as the downregulation of SQSTM1 and YTHDC1, may contribute to delayed wound healing in diabetic skin. These findings suggest a previously unrecognized role for YTHDC1 in modulating autophagy through regulating SQSTM1 stability, highlighting a potential therapeutic target for improving wound healing in diabetes.
Article
Chemistry, Multidisciplinary
Yuan Xiong et al.
Summary: The novel HA@MnO2/FGF-2/Exos hydrogel can improve diabetic wound healing by forming a protective barrier and providing long-term antibacterial protection, while utilizing MnO2/ε-PL nanosheets to catalyze H2O2 conversion to O-2, releasing M2 Exos and FGF-2 to promote the healing process.
Article
Chemistry, Multidisciplinary
Yang Li et al.
Summary: This study develops an injectable hydrogel based on MXene nanosheets for diabetic wound healing. The hydrogel utilizes oxyhemoglobin to release oxygen controllably and MXene to scavenge reactive oxygen species and bacteria. The hydrogel also benefits from the regulation of macrophage polarization. Overall, it effectively promotes the healing of infected diabetic wounds.
Article
Engineering, Biomedical
Yaxi Wang et al.
Summary: The study demonstrates the potential therapeutic effect of EVs loaded with VH298 on diabetic wound healing and angiogenesis, as well as the sustained release of VH-EVs through GelMA hydrogel.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Yuna Qian et al.
Summary: A novel glycyrrhizic acid-based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing.
ADVANCED MATERIALS
(2022)
Review
Cell Biology
Luka Culig et al.
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Sophia Maschalidi et al.
Summary: SLC7A11 acts as a negative regulator of efferocytosis, inhibiting its function can accelerate wound healing; it has important implications for wound management in diabetes.
Article
Chemistry, Multidisciplinary
Jing Liu et al.
Summary: This study designed a hemostatic and anti-inflammatory hydrogel patch for promoting diabetic wound healing. The hydrogel was able to regulate macrophage phenotype, promote fibroblast proliferation and migration, and accelerate angiogenesis. The hydrogel can effectively promote wound closure and tissue regeneration, making it a simple, economical, effective, and safe treatment for diabetic wounds.
Article
Chemistry, Multidisciplinary
Daiyong Chao et al.
Summary: This study presents an effective antioxidative system for diabetic chronic wound healing by integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel), which can modulate the oxidative stress microenvironment and transition from the inflammation phase to the proliferation phase, comparable to a widely used clinical drug.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Baohong Sun et al.
Summary: This study reports a versatile integrated nanoagent for comprehensive treatment of diabetic wounds. The nanoagent effectively scavenges reactive oxygen species, induces anti-inflammatory response, and exhibits bactericidal capabilities. In vivo experiments demonstrate that the nanoagent can accelerate the healing of infected diabetic wounds with better therapeutic benefits than monotherapy or individual antibiotics.
Article
Multidisciplinary Sciences
Wenshuai Liu et al.
Summary: A glycopeptide hybrid hydrogel with antibacterial and tissue environment-responsive properties was developed for chronic wound healing. The hydrogel can promote cell proliferation and macrophage polarization, and has potent antibacterial effects. It accelerated the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic and scalding skin by promoting M2-type macrophages, reducing inflammation, and promoting angiogenesis.
Article
Chemistry, Multidisciplinary
Huan Lei et al.
Summary: In this study, TA-siRNA nanogels were prepared and their therapeutic effect on diabetic wounds was enhanced by responding to reactive oxygen species levels and electrical stimulation. The nanogels were found to reduce the expression of MMP-9, promote collagen synthesis and angiogenesis, thereby accelerating wound healing.
Article
Physiology
Margaret R. MacLean et al.
Summary: Serotonin plays a significant role in pulmonary arterial hypertension (PAH), with elevated synthesis of serotonin being associated with pathogenic effects. Targeting serotonin synthesis or signaling presents a promising alternative approach for the treatment of PAH.
COMPREHENSIVE PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sushrut Kamerkar et al.
Summary: Researchers have developed an engineered exosome therapeutic candidate that selectively silences the expression of STAT6 gene in tumor-associated macrophages (TAMs). This drug shows high efficacy in inhibiting tumor growth and inducing complete remissions in colorectal cancer and hepatocellular carcinoma models. It also remodels the tumor microenvironment and triggers a specific immune response mediated by CD8 T cells.
Review
Chemistry, Multidisciplinary
Mayland Chang et al.
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xue-Han Xu et al.
Summary: Exosomes derived from ginseng were shown to efficiently promote neural differentiation of BMSCs by transferring miRNAs, demonstrating potential for neural regenerative medicine both in vitro and in vivo.
Review
Endocrinology & Metabolism
Thea N. Golden et al.
Summary: Intrauterine growth restriction (IUGR) is a common complication of pregnancy that increases the risk of type 2 diabetes mellitus (T2DM) later in life for the offspring. The development and balance of the fetal immune system, the role of pancreatic-resident macrophages, and cytokines derived from beta-cells and macrophages play key roles in islet development and function. Therapeutic immunomodulation may be beneficial for treating T2DM, particularly in cases induced by IUGR.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Medical Laboratory Technology
Nicole C. Nowak et al.
Summary: Type 2 diabetes is associated with complications such as impaired wound healing, chronic ulcers, and the need for amputation. The role of nerves in wound healing in diabetic patients is not fully understood, but studying these mechanisms may lead to targeted treatments for chronic diabetic wounds.
TRANSLATIONAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Wei Qiao et al.
Summary: This study reveals a biphasic mode of action of magnesium ion (Mg2+) in bone repair. During the early inflammation phase, Mg2+ can contribute to pro-osteogenic effects by promoting an immune microenvironment for bone formation; however, in the later remodeling phase, Mg2+ has negative effects on bone maturation and repair.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Qi Lv et al.
Summary: Our study demonstrates that didymin can alleviate clinical symptoms of colitis in mice by modulating macrophage phenotypes. Mechanistic studies reveal that didymin induces the conversion of pro-inflammatory M1-like macrophages to anti-inflammatory M2-like macrophages through enhancing fatty acid oxidation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ya Guan et al.
Summary: The study developed a sustained oxygenation system using oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel to promote diabetic wound healing. The sustained release of oxygen enhanced cell survival and migration, angiogenic growth factor expression, angiogenesis, and decreased proinflammatory cytokine expression in diabetic wounds, leading to a significant increase in wound closure rate.
Article
Chemistry, Multidisciplinary
Yuan Xiong et al.
Article
Engineering, Biomedical
Parvaiz A. Shiekh et al.
Article
Nanoscience & Nanotechnology
Zhiyong Qian et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Developmental Biology
Shen Li et al.
DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Immunology
Andrew S. Kimball et al.
Review
Medicine, Research & Experimental
Jennifer C. Brazil et al.
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Editorial Material
Immunology
Johanna A. Knipper et al.
Article
Clinical Neurology
Elina Zakin et al.
SEMINARS IN NEUROLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Quentin Lemaire et al.
JOURNAL OF NANOBIOTECHNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Zhong-Wei Luo et al.
Article
Endocrinology & Metabolism
Gidon J. Boenhofl et al.
Review
Endocrinology & Metabolism
Beata Lecka-Czernik
Review
Chemistry, Multidisciplinary
Nuria Oliva et al.
ACCOUNTS OF CHEMICAL RESEARCH
(2017)
Review
Chemistry, Multidisciplinary
Tianmeng Sun et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2014)
Review
Medicine, General & Internal
V Falanga
Review
Medicine, General & Internal
N Singh et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2005)
