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Article
Engineering, Environmental
Xinfa Cai et al.
Summary: Sensitive and portable detection of mycotoxins using Fe-N-C single-atom nanozymes was successfully achieved. The method allowed qualitative and quantitative detection with low cost and high sensitivity, and could be observed with naked eyes or a smartphone.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Physical
Lili Xu et al.
Summary: Polymer stabilizers greatly influence the structure, size, and activity of gold nanoparticles (Au NPs). Among the polymers tested, polyacrylic acid-stabilized Au NPs exhibit the highest glucose oxidase-like activity due to their small size and weak spatial resistance. However, further tests reveal limitations in selectivity and activity in physiological environments.
Article
Chemistry, Physical
Lihong Lin et al.
Summary: In this study, a single-atom iron nanozyme was synthesized and demonstrated promising potential in bioassays based on its excellent performance.
Article
Chemistry, Analytical
Jianping Guan et al.
Summary: In this study, a single-atom nanozyme-Rh-N/C with tetra-enzyme mimic activities was constructed. The Rh-N/C showed stable and reusable laccase and oxidase mimic activities, even after 2 months of storage and 10 times of reuse with minimal loss of activity (maintained above 96.0%). Two biosensors were designed based on the versatile enzymatic activities of Rh-N/C, including a colorimetric biosensor for acetylcholinesterase activity determination and a sensitive Rh-N/C-based biosensor for adrenaline detection. This work expands the application of single-atom nanozyme and explores their potential in biosensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Chemistry, Physical
Bing Jiang et al.
Summary: Single-atom nanozymes (SAzyme) are a hot topic in current nanozyme research due to their high activity, stability, and low cost, which make them great substitutes for natural enzymes. SAzymes also have higher catalytic activities and specificity compared to traditional nanozymes due to their maximized atom utilizations and well-defined geometric and electronic structures. They have been widely applied in various biomedical areas, including anti-tumor therapy, biosensing, antibiosis, and anti-oxidation therapy. In this review, representative examples of SAzymes categorized by their biomedical applications will be discussed, along with future opportunities and challenges they face in their designs and applications.
Article
Chemistry, Multidisciplinary
Zhiwei Wang et al.
Summary: This study demonstrates a regulatory mechanism based on the electron filling and orbital energies of metal active centers and provides a rational catalyst design strategy for achieving ultrahigh H2O2-decomposition activity. Among the investigated platinum-group-metal active centers, Ir-N-4 with partially occupied d(x2-y2) and d(xz) orbitals and the highest d-band center shows the strongest interaction with H2O2 and the lowest energy barrier for its decomposition. The single-atom Ir catalyst (Ir-NC) exhibits an ultrahigh H2O2-decomposition capacity, which is 1614 times higher than that of natural catalase, and surface-adsorbed atomic oxygen is identified as the key intermediate for O2 generation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Ge Fang et al.
Summary: This study investigates the effect of spatial location of metal atoms in metal organic framework-based nanomaterials on their hydrolysis activity. UiO-67-Cu-N shows excellent performance in hydrolysis activity and inhibition of gene transfer.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Biophysics
Yadong Zhe et al.
Summary: Despite the favorable performance of nanozymes compared to natural enzymes, the development of highly specific nanozymes is still necessary to meet the requirements of exploring disease mechanisms and selective monitoring in biological systems. In this study, self-assembled GSH-Cu/Cu2O NPs with specific AA oxidase-like catalytic activity were constructed for cancer cell proliferation inhibition and neurochemical monitoring. The nanozyme exhibited improved activity through the generation of active oxygen by accelerating AA oxidation, effectively suppressing cancer cell proliferation and enabling continuous monitoring of DOPAC alterations in a rat brain acidosis model.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Ying Qin et al.
Summary: This study successfully constructed a robust PEC sensing platform by utilizing Fe single-atom catalysts on semiconductor surfaces, achieving sensitive detection of acetylcholinesterase activity and organophosphorus pesticides. This provides important guidelines for the use of SACs in sensitive PEC analysis.
Article
Chemistry, Multidisciplinary
Yuxin Xing et al.
Summary: Utilizing a novel morphology fragmentation strategy, flower-like SAC nanozymes were fabricated with improved 3D accessibility of active sites, enhancing ROS generation and biomolecule damage. This approach opens up new avenues for ROS therapy by promoting re-sensitization of drug-resistant tumors.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Daoming Zhu et al.
Summary: A light-controlled oxidative stress amplifier system is designed in this study, showing synergistic antitumor activity in solid tumors. The system self-produces H2O2 and transforms cold tumors, and the combination of photothermal therapy, chemotherapy, and nanozyme-based catalytic therapy further enhances tumor immunogenic death and antitumor immunity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bolong Xu et al.
Summary: Single-atom nanozymes are a new research frontier in the biomedical fields. A melamine-mediated pyrolysis activation strategy has been used to controllably fabricate iron-based SAzymes with a five-coordinated structure (FeN5). The FeN5 SAzyme shows excellent peroxidase-like activity and significantly enhanced antitumor effect in vitro and in vivo.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sujiao Cao et al.
Summary: Metal-N-coordinated centers supported by carbonaceous substrates have been synthesized and compared in terms of catalytic activities, substrate selectivities, kinetics, and reactive oxygen species (ROS) products. The electronic structures of the metal centers were found to be highly related to the ROS-catalytic paths and activities.
ADVANCED MATERIALS
(2022)
Article
Biochemical Research Methods
Liping Sun et al.
Summary: Biothiol detection is crucial for clinical disease diagnosis. Previous nanozyme-based colorimetric sensors showed unsatisfactory catalytic activity, leading to high detection limits. Hence, it is necessary to develop new nanozymes with high catalytic activity for biothiol detection. This study explores Co-N-C SAzymes with high oxidase-like activity for colorimetric detection of biothiols, demonstrating high sensitivity and selectivity. It offers new insights for biosensing using Co-N-C SAzymes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chao Peng et al.
Summary: The study proposes a strategy to endow inert metal-organic frameworks (MOFs) with enzyme mimicking activity by introducing Cu2+, resulting in the preparation of Zr-MOF-Cu with unparalleled catalytic ability. Details on the coordination environment of Cu active sites in Zr-MOF-Cu are disclosed through electron paramagnetic resonance and synchrotron-radiation-based X-ray absorption fine structure analyses. The material enables 8-fold signal amplification and successfully constructs a universal fluorescent system for the quantitative measurement of alkaline phosphatase (ALP) activity and enzyme-linked immunosorbent assay related to ALP.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xin Luo et al.
Summary: A novel template-sacrificed strategy was reported for the synthesis of atomically dispersed Ir SASCs, which were successfully utilized for electrochemical sensing of organophosphorus pesticides with high sensitivity and selectivity. This work demonstrates the broad application prospect of ORR in sensitive detection of biomolecules.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Hui Ouyang et al.
Summary: A study on the preparation and application of yolk-shell Co SASCs highlights the potential of direct chemical interactions for the formation of highly active catalysts and their use in catalysis and chemiluminescence.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Erhuan Zhang et al.
Summary: Rarely reported is the in-depth understanding of local atomic environment-property relationships of p-block metal single-atom catalysts towards the 2e(-) oxygen reduction reaction (ORR). In this study, a heteroatom-modified In-based metal-organic framework-assisted approach is developed to synthesize an optimal catalyst, In SAs/NSBC, with accurately anchored single In atoms supported by hollow carbon rods. The catalyst exhibits a high H2O2 selectivity and unprecedented production rates in different electrolytes, providing practical guidance for H2O2 electrosynthesis and enabling the design of high-performance single-atom materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
FanChi Meng et al.
Summary: A novel atomically dispersed Cu-3 cluster stabilized on a defect-rich nanodiamond-graphene hybrid support, Cu-3/ND@G, exhibits enhanced oxidase-like and antibacterial activity with a higher catalytic rate constant compared to previous copper single atom oxidase mimics. The atomically dispersed Cu-3 cluster shows potential applications in antibacterial materials.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Engineering, Biomedical
Yutian Su et al.
Summary: Nanozyme-based catalytic therapy plays an important role in tumor therapy by generating lethal reactive oxygen species. However, most nanozymes have mono catalytic performances in the tumor microenvironment, which lowers their therapeutic efficiency. In this study, a newly-developed nanozyme with dual enzyme-mimic catalytic activity is designed, which can achieve an enhanced nanocatalytic therapy effect through photothermal augmentation.
Article
Biophysics
Lihua Shen et al.
Summary: Machine learning algorithms combined with SANs sensors can efficiently process large quantities of data and accurately detect substances such as ascorbic acid. This method has broad application prospects and can be used for the detection of disease-related proteins and cells in the future.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Youyou Feng et al.
Summary: The combination of mesoporous Fe-N-C SAzyme with photothermal treatment enhances the catalytic performance, resulting in a more effective antibacterial treatment compared to using single antibacterial methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Environmental
Qiumeng Chen et al.
Summary: The study introduced a Fe-Bi bimetallic MOF-derived single-atom nanozyme, FeBi-NC, with dual metal-Nx catalytic sites for pollution remediation. FeBi-NC showed high oxidase mimicking activity and was used for sensitive screening of AChE activity, demonstrating strong peroxymonosulfate activation capability for rapid degradation of rhodamine B. The high activity of FeBi-NC is attributed to the isolated Fe-N-4 and Bi-N-4 sites and their synergy.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xiao Hai et al.
Summary: A general approach combining wet-chemistry impregnation and two-step annealing enables the scalable synthesis of ultra-high-density single-atom catalysts with metal contents up to 23 wt%, showcasing significantly enhanced reactivity. This method allows for the exploration of a vast library of mono- or multimetallic catalysts with tunable metal loadings.
NATURE NANOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Gao-Feng Han et al.
Summary: A solvent-free and zero-waste method for synthesizing single-atom catalysts from bulk metals has been reported. This method is applicable to different metals and supports, and it offers a green and efficient approach for the commercialization of single-atom catalysts.
NATURE NANOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Julia Razlivina et al.
Summary: Enzymes face challenges such as high cost, complex purification, and low stability. Developing low-cost artificial enzymes with comparable or higher effectiveness is desired. Computational approaches show success in modeling nanozyme activities, but require assumptions about the system. Machine learning offers an alternative way to predict material properties, even in complex systems. In this study, a user-friendly expandable database of over 300 inorganic nanozymes is developed, along with a random forest regression model for peroxidase activity prediction. The DiZyme resource, including the database, predictive algorithm, and visualization tool, is also created to promote novel nanozyme discoveries worldwide.
Article
Multidisciplinary Sciences
Limei Qin et al.
Summary: Developing effective methodologies to construct highly active catalytic sites for material engineering is attractive. A novel interfacial-confined coordination strategy was proposed to anchor Fe single atoms on defective carbon dots in a biocompatible mesoporous silica nanoreactor, showing efficient energy conversion capability under physical and biochemical stimuli. The highest photothermal conversion efficiency is proposed by theoretical DFT calculations, providing a scientific paradigm for versatile single atom nanotherapeutics for tumor therapy.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Vera Giulimondi et al.
Summary: A gas-phase redispersion strategy has been developed to disperse Ru, Rh, and Ir nanoparticles supported on commercial activated carbon into small clusters and single atoms, allowing for precise size control and high-density metal sites with tuneable nuclearity for tailored applications.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Yuan Chen et al.
Summary: This study presents a single-atom nanozyme Cu SAs/CN with APX-like behavior, showing comparable activity and kinetics to natural APXs. Through density functional theory, the Cu-N-4 moieties in the active center of Cu SAs/CN are determined to facilitate the activation and cleavage of H2O2 molecules, resulting in fast kinetics.
Article
Chemistry, Multidisciplinary
Qiang Luo et al.
Summary: This study presents the construction of a chromium single atom nanozyme capable of performing nonsacrificial H2O2 photosynthesis and haloperoxidase-mimicking activity for antibiofouling. The nanozyme can generate H2O2 from water and O-2 under visible-light illumination, and sustainably supply H2O2 for a haloperoxidase-mimicking reaction. This dual-activity nanozyme overcomes the instability of natural enzymes and inadequate H2O2, resulting in continuous production of hypobromous acid with remarkable bactericidal capability. The application of the nanozyme as an eco-friendly coating additive demonstrates its effectiveness in preventing marine biofouling.
Article
Nanoscience & Nanotechnology
Shan Wang et al.
Summary: In this study, atomically dispersed Fe, Pt dinuclear catalysts were synthesized and exhibited synergistic catalytic performance in tumor microenvironments. The Fe-N-3 moiety effectively initiated the Fenton reaction and induced tumor cell apoptosis, while the bonded PtN4 moiety enhanced the catalytic activity of Fe-N-3 by modulating its electronic orbitals. Additionally, the presence of amorphous carbon showed high photothermal conversion efficiency, achieving effective cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Hui Wang et al.
Summary: This study presents the construction of biocompatible and trackable-imaging single-atom nanozymes (SAzymes) with efficient catalytic activities. The enzyme-like activity was enhanced by tenfold by varying the calcination conditions. Moreover, the Co/TiO2 SAzymes exhibited good intrinsic biocompatibility and excellent tolerance toward the biological medium, while the hollow structure facilitated the loading of drugs and imaging agents for image-guided chemo-chemodynamic therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Zhichao Wu et al.
Summary: A novel tris(bipyridine) ruthenium(II)-based ternary chemiluminescence system has been proposed in this study, utilizing cobalt nanoparticles and peroxymonosulfate to enhance the efficiency of chemiluminescence. The prepared chemiluminescence biosensor exhibits good linear range, sensitivity, and selectivity under optimized conditions.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chong-Bo Ma et al.
Summary: This study presents a facile synthetic strategy for a dual single-atom nanozyme composed of zinc (Zn) and molybdenum (Mo). The nanozyme utilizes polyoxometalates and supramolecular coordination complexes as metal-atom precursors, and an amphiphilic aerogel as the supporting substrate. The dual single-atoms of Zn and Mo exhibit a synergistic effect and peroxidase-like activity. The nanozyme shows outstanding stability and is capable of detecting various analytes in different samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Wei Li et al.
Summary: This study presents a CdS-Pd nanocatalyst with improved stability and activity for solar-induced overall water splitting. The CdS-Pd nanocatalyst showed 110-fold higher activity than pristine CdS. It also demonstrated high apparent quantum yields under broadband light illumination. The findings provide important insights for the development of stable and efficient CdS-based photocatalysts for hydrogen production.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Biophysics
Bin Li et al.
Summary: This study synthesized single-atom platinum-anchored Zn0.5Cd0.5S nanostructures to construct a photoelectrochemical immunosensor for detecting prostate-specific antigen (PSA). The ion-exchange reaction between CuO-labeled secondary antibody and the nanostructures significantly improved the photocurrent, enhancing the sensitivity of the immunoassay. The immunoassay exhibited a detection range of 1.0 to 10000 pg/mL for PSA, with a limit of detection of 0.22 pg/mL, along with good repeatability, strong anti-interference, and high accuracy.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Tingting Zhang et al.
Summary: In this study, a new type of biomimetic cascade nanoreactor was designed and utilized for acid phosphatase (ACP) detection. The nanoreactor exhibited triple-enzyme mimetic activities and achieved ACP colorimetric detection through a cascade amplification strategy. This Co,N-CNC nanoreactor displayed promising applications in biosensing, medical diagnostics, and biotechnological research.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Yi Yu et al.
Summary: This study prepares an injectable ointment based on MOF-based single-atom catalysis systems, which exhibits high anti-biofilm activity and provides a rapid, effective, non-invasive, and convenient strategy for the treatment of periodontitis without antibiotics. The ointment shows superior therapeutic effectiveness compared to the clinically used Periocline.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Hongyin Xia et al.
Summary: In this study, the relationship between intrinsic oxygen reduction reaction (ORR) activity and electrochemiluminescence (ECL) behavior was explored using single-atom catalysts (SACs). By combining electrochemical ORR catalyzed via SACs and chemical oxidation of luminol, the traditionally neglected cathodic ECL emission of luminol was significantly enhanced. This work is important for guiding the development of an amplified sensing platform through rational tailoring of the ORR activity of SACs and potential-resolved ECL assays based on high-efficiency cathodic ECL.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Daoming Zhu et al.
Summary: A biomimetic single-atom nanozyme system was developed for self-enhanced nanocatalytic tumor therapy (NCT) by combining platelet membrane vesicles, a proton pump inhibitor, and copper nanozymes. The system demonstrated good tumor-targeting capabilities and efficient catalytic activity, while also regulating the hydrogen ion, glutathione, and hydrogen peroxide levels in tumor cells to improve therapeutic effect. In vivo studies showed a high tumor suppression rate, and the integration of glutamine metabolism therapy with nanocatalytic tumor therapy provides a novel strategy for multimodal tumor treatment.
Article
Chemistry, Physical
Hao Wang et al.
Summary: Recently, there has been increased attention on the study of mimic enzymes. However, research on the oxidoreductase activity of electron mediators in the biological respiratory chain is still limited. In this study, we found that cadmium sulfide (CdS) nanorods can catalyze the formation of superoxide anions and exhibit NADH oxidase-like activity and Cyt c reductase-like activity. This provides a new perspective for the in-depth study of new nanozymes.
Article
Chemistry, Multidisciplinary
Mengyan Zhao et al.
Summary: This study presents a dual-active site monodisperse catalyst that can generate tumor-related reactive oxygen species and achieve highly efficient tumor therapy through synergistic catalytic reactions. In vitro and in vivo experiments demonstrate that this catalyst can effectively induce cell apoptosis and inhibit tumor growth with low metal concentrations and high therapeutic effects.
Article
Multidisciplinary Sciences
Jinxing Chen et al.
Summary: This article reports the synthesis of a single-atom rhodium catalyst based on flavin-dependent oxidase for the production of hydrogen peroxide. The catalyst exhibits high efficiency and selectivity in the reduction of oxygen to hydrogen peroxide. Compared to electrocatalytic oxygen reduction reactions, the commercial Pt/C-catalyzed enzymatic reactions show higher selectivity for hydrogen peroxide.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Y. Xiong et al.
Summary: A phosphatase-mimicking nanozyme CeO2 with ultra-small structure and excellent dispersibility has been successfully synthesized, which can effectively dephosphorylate NADP(H) and inhibit the biosynthesis of GSH in non-redox biological applications.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wei Wang et al.
Summary: This study introduces a photothermal nanozyme with haloperoxidase-like activity, which generates heat to greatly accelerate the reaction kinetics. It exhibits superior antibacterial activity and can be used for biofouling prevention in real marine conditions.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yafei Zhao et al.
Summary: In this study, a facile method for the preparation of Ni single atoms embedded hollow S/N-doped carbon macroporous fibers (Ni SAs@S/N-CMF) as efficient catalysts for oxygen evolution reaction (OER) was reported. The catalysts demonstrated excellent activity and stability, attributed to the abundantly exposed single Ni atoms and hollow macroporous structure.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xin Li et al.
Summary: This study achieves highly reversible encapsulation-based sodium storage by designing a functional hollow carbon nanotube with Zn single atom sites embedded in the carbon shell. The design reduces the nucleation barrier of Na deposition and provides excellent ion/electron transport channels, improving the safety and cycling performance of the sodium metal anode.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ruofei Zhang et al.
Summary: This study rationally designed an iron-based nanozyme with excellent catalytic performance and demonstrated its potential therapeutic effects on retinal vasculopathies by scavenging ROS and alleviating oxidative stress. The nanozyme showed promising catalase-like activity and provided a new approach for refining nanozymes through engineering the defect environment and geometric structure around metal sites.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Fuad Abduro Bushira et al.
Summary: In this study, an efficient luminol-DO ECL system was developed through the complexing of Fe, Co dual single-atom catalysts (D-SACS) supported by N-doped graphene with the luminol-capped Ag nanoparticles (AgNPs). The performance of the corresponding ECL system could be significantly boosted up to 677-fold under optimal testing conditions, comparable to the classic luminol-O-2 system. The developed luminol-DO ECL system was successfully applied for the stable ultrasensitive detection of prostate-specific antigen (PSA) in a wide linear range of 1 fg/mL to mu g/mL, with a low limit of detection (0.98 fg/mL).
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shuangfei Cai et al.
Summary: Nanocatalytic therapy, involving nanozyme-triggered production of reactive oxygen species (ROS) in the tumor microenvironment, has potential in tumor therapy. However, nanozymes still face challenges of activity and specificity. This study introduces a strategy based on a single-atom nanozyme for cascade enzymatic reactions in the tumor microenvironment, showing promising results in efficient tumor therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Qiang Chen et al.
Summary: In this study, single platinum atoms were selectively encaged in the six-membered rings of sodalite (SOD) cages within Y zeolite using a template-guiding strategy. The Pt@Y-SOD catalyst showed good stability, excellent catalytic selectivity in the semihydrogenation reaction, and resistance to thiophene and carbon monoxide due to the configuration of the encaged single platinum atoms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biophysics
Min Feng et al.
Summary: In this study, highly active single-atom nanozymes (SAzymes) were designed and realized for the first time, and a novel colorimetric method for detecting PPD in hair dyes was developed based on their peroxidase-like activity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Ting Pan et al.
Summary: A novel nanozyme CS@Fe/CDs was designed to combat bacterial biofilms. Through the peroxidase-like catalytic activity and antibacterial activity of CS, CS@Fe/CDs effectively cleaved extracellular DNA and caused cell death within bacterial biofilms. This approach shows great potential in managing bacterial biofilm fouling in food safety and environmental protection.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Pir Muhammad et al.
Summary: This study explored the use of single-atom nanozymes for the treatment of drug-resistant glioblastoma and successfully inhibited tumor growth.
Article
Environmental Sciences
Rui Li et al.
Summary: In this study, nitrogen and sulfur coordinated Fe-N/S-C SAzymes were synthesized using peanut shells as carbon, nitrogen, and sulfur source. The SAzymes showed high oxidase-like activities due to doping of sulfur, and this property was further confirmed by density functional theory calculations. A novel on-off-on colorimetric sensor was developed based on the SAzymes for simultaneous detection of GSH and Hg2+, with good analytical performance in real samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Analytical
Ming Mu et al.
Summary: This review systematically presents the recent development of fabrication, properties, and applications of nanozyme-SERS systems. The fundamentals of nanozymes and SERS technique are introduced, followed by the classification of nanozyme-SERS systems. The influence factors on the properties of nanozyme-SERS systems and their applications in various fields are discussed. The challenges and perspectives to construct new nanozyme-SERS systems are also emphasized.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Shaofang Zhang et al.
Summary: The authors developed single-atom nanozymes of RhN4, VN4, and Fe-Cu-N-6 with higher catalytic activities than natural enzymes, and demonstrated the recyclability of Rh/VN4 and the scalp healing properties in bioactive sutures.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Wenxiu Han et al.
Summary: The study developed a therapeutic platform by wrapping doxorubicin in mesoporous CNTs/Fe-N-C with the cell membrane, showing high antitumor activity due to efficient catalytic ability, increased drug release rates, and significant photothermal effect.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xianyu Zhu et al.
Summary: This study developed an external-field-enhanced nanozyme for tumor theranostics. The nanozyme exhibited peroxidase-like activity and self-cascade enzymatic activity, and showed improved tumor growth inhibition with minimal side effects in vivo through the synergistic effect of radiotherapy and self-cascade enzymatic therapy.
Article
Chemistry, Multidisciplinary
Jieying Liang et al.
Summary: This study successfully developed a generalized strategy to construct highly active ferric-centered single-atom catalysts (Fe-SACs) and demonstrated their superior performance in catalytic reactions and suppressing tumor cell growth. The strategy can be generalized to different metalloproteins and enzymes, providing new possibilities for the development of efficient SACs.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Yuchan Ma et al.
Summary: Ni single-atom catalysts (SACs) were synthesized and functionalized to develop highly sensitive electrochemiluminescent (ECL) probes for biosensors. The functionalized Ni SACs exhibited good aqueous dispersibility and could significantly enhance the ECL signal, making them suitable for various applications in biosensing.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Rufen Wu et al.
Summary: This study presents the design of a precise triple-metal-atom catalyst that mimics the activity of oxidase for various catalytic reactions. The catalyst shows promising application in biosensors with high sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mengyu Chang et al.
Summary: In this study, a polyporous Cu single atom nanozyme loaded with licogliflozin (LIK066) was designed to achieve efficient mild photothermal therapy (PTT) by inhibiting heat shock proteins (HSPs) synthesis and damaging existing HSPs in cancer cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biophysics
Ying Wang et al.
Summary: Nanozymes, heterogeneous nanomaterials with enzyme-like characteristics, offer significant advantages as alternatives to natural enzymes. Single-atom nanozymes (SAzymes), composed of single-atomic active sites, have remarkable enzyme-like activity and specificity. This review provides an overview of SAzymes, including their discoveries, advantages, and classifications, as well as discussions on reaction mechanisms, design principles, and biosensing applications. The challenges and future perspectives of SAzymes as the next-generation nanozymes are also discussed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Guangchun Song et al.
Summary: Single-atom nanozymes exhibit attractive enzyme-like activities, particularly phosphatase-like activity. The combination of Al3+ and the O atom in its structure can inhibit its enzyme activity. A fluorescent sensor for detecting Al3+ was constructed based on single-atom nanozymes, enabling fast and efficient detection.
Article
Chemistry, Multidisciplinary
Xin Li et al.
Summary: This work presents the design and synthesis of single-atomic iron doped carbon dots with tunable fluorescence and exceptional oxidase-mimetic activity. Phosphate ions can suppress the activity and restore the photoluminescence of the carbon dots, leading to the development of a dual-mode colorimetric and fluorescence assay for phosphate monitoring.
Article
Chemistry, Physical
Xueliang Liu et al.
Summary: Single-atom catalysts (SACs) have shown promising applications due to their atomic utilization and catalytic properties. In this study, a novel strategy was developed to synthesize Co single-atom catalyst (Co-SAC) with exclusive Co-N4 active sites. The Co-SAC exhibited excellent oxidase-like activity and was successfully applied in colorimetric assay for AA and ACP.
APPLIED SURFACE SCIENCE
(2022)
Article
Engineering, Environmental
Ge Kang et al.
Summary: The study demonstrates the exceptional oxidase-like activity of single-atom Pt catalysts, which enhances the generation of H2O2 and 1O2 species, facilitating the chromogenic reaction. Based on this, a novel colorimetric assay for α-Glu is designed and successfully applied to serum samples, showing excellent analytical performance.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Yixin Yu et al.
Summary: Improving the catalytic activity and expanding the scope of nanozymes, with the aid of machine learning, can enhance the development of nanozymes. A study on the peroxidase (POD) mimic reaction catalyzed by nonmetal atom doped graphdiyne (GDY) identified two GDYs (B-GDY and N-GDY) with the best performance. The extreme gradient boosting (XGB) algorithm was used to predict the relationship between model parameters and energy barriers, reducing calculation efforts. The experimental results validated the accuracy of the predicted trends, demonstrating the potential of machine learning in optimizing nanozyme performance.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Changshuai Shang et al.
Summary: This study reports the synthesis of amorphous/crystalline PtRuTe nanozymes with selectively enhanced peroxidase-like activity and suppressed oxidase-like activity. The amorphous domains play a critical role in tuning and optimizing the catalytic properties, and the high-percentage defects of the PtRuTe nanozyme exhibit superior catalytic activities and kinetics.
Article
Chemistry, Multidisciplinary
Xiaoqian Wei et al.
Summary: This study used spin state engineering to enhance the catalytic performance of Fe single-atom nanozymes through the introduction of Pd nanoclusters. The spin-rearranged FeNC-Pd-NC showed improved peroxidase-like activity and achieved an ultralow detection limit in the colorimetric detection of prostate-specific antigen.
Article
Chemistry, Multidisciplinary
Rui Gao et al.
Summary: A hierarchically mesoporous cerium metal-organic framework (Ce-HMMOF) nanozyme with enhanced ALP-mimicking activity is developed for naked-eye detection of phosphorylated biomarkers. The long-range ordered mesochannels in Ce-HMMOF promote mass transfer and accessibility of interior active sites, enabling rapid and sensitive sensing of phosphorylated biomarkers through ALP-like biocatalysis. This work provides new insights into the engineering of highly active nanozymes for disease-associated biomarker screening and diagnosis.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Physical
Bing Jiang et al.
Summary: Single-atom nanozyme (SAzyme) is a hot topic in current nanozyme research, due to its high activity, stability, and low cost. Compared to traditional nanozymes, SAzyme exhibits higher catalytic activities and specificity. In biomedical areas, SAzyme has been widely applied in anti-tumor therapy, biosensing, antibiosis, and anti-oxidation therapy.
Article
Chemistry, Multidisciplinary
Weiwei Wu et al.
Summary: This article investigates the inhibitory effect of nanozymes and the advantages of single-atom Fe-N-C nanozymes in mechanism research. The study finds that a common analgesic-antipyretic drug inhibits the oxidase-like activity of Fe-SANs in a reversible mixed-inhibition manner. Additionally, a calorimetric method for drug detection based on nanozyme inhibition is proposed.
Review
Materials Science, Multidisciplinary
Liwen Xing et al.
Summary: This review provides a detailed summary of the emerging top-down synthetic strategies for single-atom catalysts (SACs), including methods based on thermochemistry, electrochemistry, and other new protocols. These strategies not only help establish complete methodologies for task-specific SACs, but also contribute to a deeper understanding of deactivation and regeneration mechanisms of supported metal catalysts for potential industrial applications.
Article
Engineering, Environmental
Yamei Lin et al.
Summary: A novel nitrogen-doped carbon material Fe1@CN20 was developed as a laccase mimic, offering better stability and recyclability, and showing more sensitive performance in the detection and degradation of phenolic compounds.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Qiming Sun et al.
Summary: Zeolite-supported metal catalysts have shown superior activity and thermal stability in catalytic reactions, being widely applied in hydrogenation, dehydrogenation, oxidation, and other reactions, with promising prospects for future advancements.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Liping Sun et al.
Summary: The study focuses on enhancing the aqueous dispersion and recognition ability of SAzymes by engineering DNA onto them, offering new insights for their application in bioanalysis. By studying the interactions between Fe-N-C SAzymes and DNA, it was found that adenine and thymine had higher adsorption affinity on Fe-N-C SAzymes.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Xiaofei Gong et al.
Summary: Iron-nitrogen-carbon materials are being studied as promising substitutes for Pt-based electrocatalysts for the oxygen reduction reaction. The 1D porous iron/nitrogen-doped carbon nanorods show exceptional ORR activities and demonstrate outstanding performance in Zn-air batteries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Juqun Xi et al.
Summary: This study presents a novel strategy to design an artificial peroxisome using a nanozyme with stable and multiple enzymatic activities, which shows promising therapeutic effects for treating hyperuricemia and protecting neurons during ischemic stroke. The nanozyme-based artificial peroxisome is considered a promising candidate for in vivo functions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yuxuan Lu et al.
Summary: The adsorption behavior of HMF on Co3O4 has been studied, and the adsorption energy can be tuned by decorating with single-atom Ir, enhancing the overall conversion efficiency of HMF on electrocatalysts.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Physical
Yu Meng et al.
Summary: The gas-phase fluorination-assisted method effectively anchors single atom Fe-Nx moieties on SWCNT film, forming high density Fe-Nx active sites, while maintaining the film quality for use as a bifunctional oxygen electrode. The single-atom Fe-Nx loaded film exhibits better catalytic activity than commercial catalysts and shows low charge-discharge voltage gap and high power density in Zn-Air batteries.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Multidisciplinary Sciences
Haile Liu et al.
Summary: Clusterzymes based on Au-25 clusters exhibit high catalytic activity and selectivity in enzyme-mimicking reactions, such as GPx-like, CAT-like, and SOD-like activities. They can effectively decrease oxidative stress and inflammation in injured brain, showing promise in mitigating neuroinflammation.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Cong Wang et al.
Summary: A new route for further improving Pt catalytic efficiency by cobalt and Pt dual-single-atoms on titanium dioxide surfaces is reported, which contains a fraction of nonbonding oxygen-coordinated Co-O-Pt dimers. This strategy yields an ultrahigh and stable photocatalytic activity, surpassing those of equal amounts of Pt single-atom and typical Pt clustered catalysts.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yang Zhu et al.
Summary: The Mn/PSAE constructed here demonstrates significant catalytic activity in weakly acidic tumor environments, which enables the generation of sufficient reactive oxygen species (ROS) through a series of cascade reactions to effectively kill tumor cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yuanjun Chen et al.
Summary: A novel and efficient strategy was reported to access high-performance nanozymes by atomizing platinum nanoparticles into single atoms, leading to dramatically enhanced enzymatic performance. The engineered single-atom Pt nanozyme exhibited remarkable catalytic activity and kinetics, far exceeding traditional Pt nanoparticle nanozymes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Daji Wang et al.
Summary: The outbreak of SARS-coronavirus 2 has become a global health emergency, with no effective treatment available. A TiO2 supported single-atom nanozyme containing atomically dispersed Ag atoms, Ag-TiO2 SAN, has high adsorption of SARS-CoV2 pseudovirus and shows promising antiviral effects.
Article
Chemistry, Multidisciplinary
Lei Jiao et al.
Summary: This study successfully synthesized atomically dispersed Fe catalysts with unsymmetrically coordinated Fe-N3S1 active sites, demonstrating higher POD-like activity compared to FeNC. The S doping-induced geometric/electronic effects of Fe-N3S1 effectively lowered the energy barrier for the formation of the active intermediate.
Article
Chemistry, Multidisciplinary
Zheng Xi et al.
Summary: Nickel-platinum nanoparticles (Ni-Pt NPs) are highly efficient mimics of peroxidase with a record high catalytic efficiency, achieving catalytic constants significantly higher than conventional Pt nanoparticles and natural peroxidases. The unique surface structure weakens the adsorption of key intermediates during catalysis, leading to boosted catalytic efficiency. Ni-Pt NPs have been successfully applied in immunoassays with ultralow detection limits.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Ying Qin et al.
Summary: Single-atom catalysts, especially platinum single atoms (Pt SAs), show great potential in catalyst design, with Pt SAs supported by nanomaterials demonstrating superior performance, particularly in photoelectrochemical biosensing, enhancing detection sensitivity for specific analytes.
Article
Chemistry, Multidisciplinary
Lu Cheng et al.
Summary: Nanozymes offer significant advantages over natural enzymes and have diverse applications. The oxidation of OPD by nanozymes is a standard protocol for determining their activities, but the mechanism of this process differs from natural enzymes. The study found that OPD polymerization on nanozyme surfaces alters their intrinsic properties, impacting the reliability of OPD-based colorimetric methods for activity determination.
Article
Chemistry, Multidisciplinary
Ying Wang et al.
Summary: Researchers have reported on the theoretical design and experimental realization of heterogeneous molybdenum single-atom nanozymes, showing that the coordination number can regulate the peroxidase-like specificity and allow for precise control of their enzymatic properties.
Article
Engineering, Biomedical
Qiqi Xu et al.
Summary: A novel FePN SAzyme is introduced in this study for photothermal/chemodynamic synergistic therapy of bacterial-infected wounds in the biofilm microenvironment. The nanozyme shows high efficiency, specificity, and sensitivity, and can be activated by internal and external stimuli in the biofilm, minimizing side effects on healthy tissue.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Analytical
Xiaoqian Wei et al.
Summary: The rational construction of advanced sensing platforms to sensitively detect H2O2 produced by living cells is a challenge in both physiological and pathological fields. Single atomic site catalysts (SASCs) with intrinsic peroxidase (POD)-like activity have shown great promise for H2O2 detection, but there is still a gap between them and natural enzymes. A new design of synergistically enhanced single atomic sites for electrochemical sensing applications is proposed in this work.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Guojuan Chen et al.
Summary: In this study, PdPt bimetallic nanozymes were used as efficient alternatives to natural enzymes in photoelectrochemical biosensing systems, leading to amplified signals and enhanced performance. By modifying photoactive CdS nanorods with PdPt bimetallic nanozymes, a sensitive PEC immunoassay for CEA detection was successfully constructed, achieving a wider linear range and lower detection limit. This research demonstrates the potential of using nanozymes for developing ultrasensitive PEC biosensors, with improved performance and signal amplification.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mengyu Chang et al.
Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Environmental
Yu Mao et al.
Summary: The article introduces a colorimetric sensing method for Cr(VI) based on single-atom nanozymes, achieving detection through specific interactions, with high sensitivity and selectivity, and successful application in Cr(VI) detection in water and food samples.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Biomedical
Xianwen Wang et al.
Summary: This study highlights the enhanced catalytic activity of nanozymes through the construction of Cu SASs/NPC for photothermal-catalytic antibacterial treatment strategy. The introduction of Cu significantly improves the catalytic performance of nanozymes, effectively killing bacteria and improving sterilization effect. The synergistic PTT-catalytic antibacterial strategy shows almost 100% antibacterial efficiency against E. coli and MRSA, demonstrating wide bio-applications of Cu-containing catalysts in antibacterial and anti-infective treatments.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Physical
Jing Li et al.
Summary: The research demonstrates a metal-MOF synergistic catalysis strategy by loading Pt nanoparticles to improve peroxidase-like activity for efficient and robust colorimetric glucose detection, showing potential for sensitive and specific diagnosis of clinical diabetes.
Article
Chemistry, Physical
Shufang Ji et al.
Summary: By precisely controlling the electronic structure of the single-atom iron active center, FeN3P-SAzyme exhibits catalytic activity and kinetics comparable to natural enzymes, showing promising potential as an effective therapeutic strategy for inhibiting tumor cell growth.
Article
Nanoscience & Nanotechnology
Wenyu Wang et al.
Summary: This study successfully constructed Ru single-atom enzymes with superior activity and stability by using carbon dots as the carrier material, leading to a lethal effect on cancer cells. The Ru single-atom enzymes exhibit excellent peroxidase-like activity, activating H2O2 to produce reactive oxygen species that cause damage to cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Physical
Vishal Kandathil et al.
Summary: Nanozymes, with their intrinsic enzyme-like activity, have gained significant attention in the scientific community worldwide. The development of Single-Atom Nanozymes (SANs) presents numerous opportunities for real-time applications in various fields. By evenly distributing active sites on a solid support, SANs exhibit high efficiency, activity, and sustainability, similar to homogeneous catalysts.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Yifeng Chen et al.
Summary: In this study, highly active POD-like nanozymes were synthesized by loading Pt clusters on Fe single-atom nanozymes, exhibiting remarkable enzyme-like activities. The cascade signal amplification strategy based on these nanozymes showed excellent sensitivity and selectivity in biosensing applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Weiqing Xu et al.
Summary: The study designed a coordination structure of Fe-N-C single-atom catalysts, with the axial ligand-engineered NG-Heme showing superior enzyme-like activity, vividly mimicking the active sites of peroxidase and being applicable in clinical sample analysis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Wenling Gu et al.
Summary: This study demonstrates the potential application of carbon-supported nickel SACs as coreaction accelerators in enhancing ECL signals; By modulating the surrounding environment of the center metal atoms, control over oxygen reduction behaviors to selectively produce intermediate ROS provides an important opportunity for studying the ECL process; Experimental and calculated results suggest that the superoxide radical (O-2(center dot-)) is the main radical for the ECL reaction, with the Ni-N-4/C catalyst preferred for its four-electron pathway to activate dissolved O-2 and enhance ECL emission.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yong Liu et al.
Summary: This study presents a multifunctional single-atom catalytic sites (SACs) type for enhanced cancer treatment, with the ability to selectively release drugs and induce tumor-specific Fenton reactions in the tumor microenvironment. The nanoagent modified with cell membrane demonstrates better in vivo therapeutic performance, breaking through the limitations of single-pathway therapy by combining chemodynamic therapy and chemotherapy.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Analytical
Hongye Yan et al.
Summary: The study synthesized single-atom Bi-anchored Au hydrogels to precisely regulate nanozyme activity and specificity at the atomic scale, achieving a deeper understanding of their catalytic nature. By introducing single Bi atoms, the POD-like activity was significantly enhanced, while having negligible effects on other closely related redox enzyme activities.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Jinxing Chen et al.
Summary: Gold nanoparticles exhibit enzyme-like activities and can mimic the catalytic process of glucose oxidation enzyme, producing H2O2; other noble metal nanoparticles can also catalyze glucose oxidation reaction, where oxygen is preferably reduced to water.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Dongdong Wang et al.
Summary: Single-atomic nanocatalysts/nanozymes (SACs/SAEs) are a research frontier due to their high atom-utilization efficiency and well-defined localized structure. Metal-organic frameworks (MOFs) are promising host materials for constructing SACs/SAEs, with the potential for MOF-derived SACs/SAEs through pyrolysis. The recent advances of MOF-based SACs/SAEs in enzymatic healthcare applications, such as cancer treatment and biosensing, offer great opportunities for next-generation biosafe SACs/SAEs.
Review
Chemistry, Multidisciplinary
Lei Jiao et al.
Summary: The development of highly sensitive biosensors has been a focus in recent years. Single-atom catalysts show promise in enhancing signal amplification in biosensing, offering improved sensitivity and selectivity through tunable metal-support interactions and the structural features of active sites.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Lei Jiao et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Min Su Kim et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Physical
Li-Zhi Huang et al.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2020)
Article
Chemistry, Multidisciplinary
Yue Wang et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Qun He et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Huijing Xiang et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Analytical
Yu Wu et al.
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Fangfang Cao et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Wenling Gu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Physical
Jinyi Zhang et al.
Article
Chemistry, Analytical
Qiumeng Chen et al.
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Multidisciplinary Sciences
Dongdong Wang et al.
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Zheng Xi et al.
Article
Chemistry, Multidisciplinary
Hui Ouyang et al.
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Physical
Lei Jiao et al.
Article
Chemistry, Multidisciplinary
Xiangyu Lu et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Yuan Xu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Multidisciplinary Sciences
Yu Lei et al.
Article
Nanoscience & Nanotechnology
Zhenzhong Yu et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Analytical
Xiaobin Zhou et al.
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Multidisciplinary
Minghua Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Chemistry, Inorganic & Nuclear
Xianlong Zhang et al.
COORDINATION CHEMISTRY REVIEWS
(2020)
Article
Chemistry, Analytical
Mengke Wang et al.
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Multidisciplinary
Fei Wu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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Chemistry, Physical
Xiaomei Shen et al.
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Multidisciplinary Sciences
Zhaoyuan Lyu et al.
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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Review
Materials Science, Biomaterials
Jiahui Pei et al.
BIOMATERIALS SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Weiwei Wu et al.
Article
Chemistry, Physical
Cheng Du et al.
JOURNAL OF MATERIALS CHEMISTRY A
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Pengli An et al.
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CHEMICAL COMMUNICATIONS
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Nan Cheng et al.
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Multidisciplinary Sciences
Liang Huang et al.
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Minmin Liang et al.
ACCOUNTS OF CHEMICAL RESEARCH
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Mengxia Yan et al.
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ANALYTICAL CHEMISTRY
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Yunteng Qu et al.
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Yiyun Su et al.
ANALYTICAL CHEMISTRY
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Chemistry, Analytical
Lei Jiao et al.
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Qiming Sun et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Hanfeng Hou et al.
SCIENCE CHINA-CHEMISTRY
(2019)
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Nanoscience & Nanotechnology
Ying Wang et al.
NANO-MICRO LETTERS
(2019)
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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CHEMICAL COMMUNICATIONS
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CHEMICAL COMMUNICATIONS
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Sourav Ghosh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
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Chemistry, Multidisciplinary
Jingfang Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
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Chemistry, Physical
Jinxing Chen et al.
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Biochemical Research Methods
Bing Jiang et al.
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Chemistry, Physical
Yunteng Qu et al.
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Biochemical Research Methods
Min Shen et al.
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Shan Wang et al.
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Cassandra Willyard
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Feng Li et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Yihui Hu et al.
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Wenyan Yin et al.
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SCIENTIFIC REPORTS
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(2015)
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Yu Tao et al.
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Engineering, Biomedical
Weiwei He et al.
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Hui Wei et al.
CHEMICAL SOCIETY REVIEWS
(2013)
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Filipe Natalio et al.
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(2012)
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Nicholas C. Denko
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Lizeng Gao et al.
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