期刊
ADVANCED MATERIALS
卷 35, 期 35, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202301901
关键词
atraumatic osteosarcoma therapy; aza-BODIPY; NIR-II-peak absorption; nitric oxide; photothermal therapy
A gas/phototheranostic nanocomposite is developed by combining aza-BODIPY (NA1020) with the thermal-sensitive NO donor (SNAP), providing deep tissue penetration and effective therapy. This strategy optimizes traditional photothermal therapy and offers a repeatable and atraumatic process for deep-tissue tumors, showing potential clinical applications.
Photothermal therapy (PTT) has received increasing interest in cancer therapeutics owing to its excellent efficacy and controllability. However, there are two major limitations in PTT applications, which are the tissue penetration depth of lasers within the absorption range of photothermal agents and the unavoidable tissue empyrosis induced by high-energy lasers. Herein, a gas/phototheranostic nanocomposite (NA1020-NO@PLX) is engineered that integrates the second near-infrared-peak (NIR-II-peak) absorbing aza-boron-dipyrromethenes (aza-BODIPY,NA1020) with the thermal-sensitive nitric oxide (NO) donor (S-nitroso-N-acetylpenicillamine, SNAP). An enhanced intramolecular charge transfer mechanism is proposed to achieve the NIR-II-peak absorbance (lambda(max) = 1020 nm) on NA1020, thereby obtaining its deep tissue penetration depth. The NA1020 exhibits a remarkable photothermal conversion, making it feasible for the deep-tissue orthotopic osteosarcoma therapy and providing favorable NIR-II emission to precisely pinpoint the tumor for a visible PTT process. The simultaneously investigated atraumatic therapeutic process with an enhanced cell apoptosis mechanism indicates the feasibility of the synergistic NO/low-temperature PTT for osteosarcoma. Herein, this gas/phototheranostic strategy optimizes the existing PTT to present a repeatable and atraumatic photothermal therapeutic process for deep-tissue tumors, validating its potential clinical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据