相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Chemistry, Multidisciplinary
Zhaoyun Liu et al.
Summary: A novel strategy of enhanced immunogenic cell death (ICD) immunotherapy with aggregation-induced emission (AIE) photosensitizer-loaded bovine serum albumin (BSA) nanoparticles (referred as BSA/TPA-Erdn) is reported, which can activate T cells, convert the cold tumor to hot, and reverse T cell senescence to restore the immune microenvironment for multiple myeloma (MM) treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jieqiong Xu et al.
Summary: Aggregation plays a critical role in modulating the photophysical process of organic molecules. However, rational control of function-oriented stacking mode for efficient photothermal conversion in the second near-infrared region remains a challenge. In this study, an H-aggregation of 3,3',5,5'-Tetramethylbenzidine (TMB)-TMB dication complexes was fabricated through intermolecular hydrogen bonding interactions, resulting in ultra-efficient photothermal conversion and superior tumor growth inhibition.
Article
Chemistry, Multidisciplinary
Kai Wang et al.
Summary: This article introduces a highly bright aggregation-induced emission (AIE) nanoprobe for the precise detection of atherosclerotic plaque at an early stage and the screening of anti-atherosclerosis drugs. The nanoprobes show high molar extinction coefficient, large photoluminescence quantum yield, and redshifted absorption/emission spectra compared to control compounds. These nanoprobes efficiently recognize atherosclerotic plaque at different stages and can be used to monitor the therapeutic effects of anti-atherosclerosis drugs.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Jing Mu et al.
Summary: Optical imaging is a non-invasive method with high resolution and sensitivity. Researchers have focused on developing contrast agents with near-infrared absorption or emission to improve imaging quality. This review summarizes recent advances in organic luminescent and photoacoustic materials and discusses their imaging performance and potential applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Yishen Liu et al.
Summary: In vivo imaging in the second near-infrared window (NIR-II) has provided great opportunities for biomedical research and clinical applications. This review summarizes the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. The versatile applications and imaging modalities enabled by these advanced fluorescent properties are discussed, along with the challenges and perspectives for future clinical translation to boost the progress of NIR-IIa and NIR-IIb imaging technology.
Article
Chemistry, Multidisciplinary
Yigang Wang et al.
Summary: Understanding and implementing ordered supramolecular assembly in organic photothermal materials is challenging but significant. In this study, an amphipathic squaraine dye (PSQ) with a poly (ethylene glycol) chain attached was synthesized and self-assembled into nanospheres with well-defined H-dimeric substructures. Molecular dynamics simulations were conducted to illustrate the self-assembly process. The resulting H-dimeric nanospheres showed ultrahigh photothermal conversion efficiency and exhibited good stability, biocompatibility, tumor accumulation, and efficient tumor inhibition in photothermal therapy. These findings provide a unique platform for the precise design of small-molecule photothermal agents for future clinical applications of photothermal therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yi Yuan et al.
Summary: A series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR-IIb emissions were developed for in vivo dynamic visualization of microstructures in deep tissues using an atom-programming strategy. These SOMs self-assembled into nanoparticles (NPs) and exhibited good brightness, high photostability, and satisfactory biocompatibility. They were successfully applied as probes for high-resolution imaging of blood vessels, biliary tract, and bladder with emissions over 1500 nm.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Dingyuan Yan et al.
Summary: A versatile theranostic agent, TPA-BT-DPTQ, was designed and prepared for simultaneous fluorescence imaging, photoacoustic imaging, photothermal imaging, and thermal eradication of tumors. The photothermal therapy mediated by TPA-BT-DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of distant tumors. Combining photothermal therapy with a PD-L1 antibody prevents cancer metastasis and recurrence.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yibin Li et al.
Summary: In this study, novel anionic cyanine photosensitizers with a tricyanofuran end group were designed, and supramolecular J-type aggregates in nanoparticles were achieved through counterion engineering. The results demonstrate the significant advantages of J-type aggregate nanoparticles in photosensitization, including red-shifted emission, negatively charged surface, high photostability, and enhanced singlet oxygen generation efficiency.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Keyue Liao et al.
Summary: This study investigates the viscosity-dependent dynamics of indocyanine green (ICG) for phototheranostic applications. The results demonstrate that high viscosity environments prolong the radiative transition and triplet excited-state lifetime of ICG, enhancing its fluorescence and photosensitization capability for photodynamic therapy. However, it also reduces the internal conversion, leading to inferior photothermal therapy. These findings provide important insights for precise phototheranostic and the design of novel ICG derivatives.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Biochemical Research Methods
Venu G. Bandi et al.
Summary: Through rational design, red-shifted, bioconjugatable heptamethine cyanine dyes were developed for multiplexed in vivo imaging in the shortwave-infrared/near-infrared-II region. The use of wavelengths between 1,000 and 2,000 nm enables high-resolution in vivo imaging at depths not possible with conventional optical wavelengths. Recent progress has shown a lack of bioconjugatable probes for imaging in the shortwave-infrared or near-infrared (NIR)-II range.
Article
Chemistry, Multidisciplinary
Ji Qi et al.
Summary: This study developed a new type of nanoparticles (SPSS NPs) that can achieve self-synergistic cancer immunotherapy by combining immunogenic cell death (ICD) and immune checkpoint blockade therapy. The nanoparticles can trigger a strong anti-tumor immune response and generate long-term immune memory against tumor rechallenge.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Wenjing Shi et al.
Summary: A molecule with two distinct cooperatively grown J-aggregates was studied to investigate the formation and transformation process during cooling. The thermodynamically less stable J(1) was found to be exclusively formed first, followed by the transformation to the more stable J(2) at room temperature with slow kinetics. This observation can be explained by the difference in nucleus sizes of J(1) and J(2), where the entropy effect favors the formation of smaller J(1) nuclei at higher temperature. The elongation of J(1) competes with the nucleation of J(2) at intermediate temperatures. The formation of J(2) is hindered kinetically below its elongation temperature due to slow dissociation of J(1), resulting in the depletion of monomers. Additional evidence supporting the larger nucleus size of J(2) was obtained through temperature-dependent spectral analyses and mathematic simulations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yi Qin et al.
Summary: In this study, a prism-like metallacage CDTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region was designed and constructed through the assembly of an aggregation-induced emission-active four-arm ligand with 90 Pt acceptors. C-DTTP exhibited the longest maximum emission wavelength (1005 nm) compared to previously reported SCCs and showed high photothermal conversion efficiency and superior reactive oxygen species generation behavior. In vitro and in vivo assessments demonstrated that the metallacage-loaded nanoparticles were capable of precise tumor diagnosis and complete tumor elimination through NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Hanchen Shen et al.
Summary: This article introduces a new NIR-II fluorescence imaging technique, which utilizes the AIE strategy to design a NIR-II dye with high QY. The dye is used for CL and PL resonance energy transfer, achieving high-quality imaging in animal experiments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Xiaoqing Wang et al.
Summary: In this study, a new ethylene-bridged BODIPY scaffold was designed, and an organic dye with NIR-II absorption capability was successfully obtained, demonstrating its potential application in fields such as photothermal imaging and photothermal ablation.
Article
Multidisciplinary Sciences
Aiyan Ji et al.
Summary: The article reports on the development of an acceptor molecule with improved stability in alkaline conditions, expanding the applications of small molecule NIR-II fluorophores. By combining with other molecules, the fluorescence intensity and resolution are further enhanced, demonstrating potential biomedical applications.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Hu Xiong et al.
Summary: This study reports a new D-A-D type BOIMPY-based NIR-II dye (NK1143) with improved brightness for in vivo bioimaging. The dye showed deep optical penetration and high-resolution blood vessel imaging. Additionally, the dye nanoprobe demonstrated effective targeting and visualization of various tumor xenografts, enabling precise resection of tiny metastases.
Article
Chemistry, Multidisciplinary
Masahito Murai et al.
Summary: We have disclosed a series of stable and one-dimensionally pi-extended carbocations with silicon-bridged diazulenyl-methyl cations. Connecting nonbenzenoid azulenes to a carbocation center at an appropriate position and reinforcing a planar arrangement effectively delocalizes a positive charge over the pi-conjugated skeleton. This study demonstrates the impact of the nonbenzenoid aromatic stabilization of a carbocation and the efficacy of the present design strategy for the construction of a promising pi-extended cationic motif that can form NIR-absorbing and emissive J-aggregates.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Shanliang Song et al.
Summary: This study conducted molecular engineering to design a near-infrared-II aggregation-induced emission luminogen with ultralong absorption wavelength for lymph node imaging and surgical navigation. Compared with the clinically used indocyanine green, the designed nanoparticles showed longer retention time, higher penetration depth, better signal-to-noise ratio, and greater photostability, enabling fast and accurate navigation of sentinel lymph nodes.
Review
Chemistry, Multidisciplinary
Zhijun Zhang et al.
Summary: Photo-driven theranostics, which integrate diagnostic imaging and therapeutic interventions, rely on the diverse excited-state energy conversions of theranostic agents. The applications of aggregation-induced emission luminogens (AIEgens) in this field have been extensively studied due to their favorable biocompatibility, tunable photophysical properties, unique theranostic features, and multimodal capabilities. This review summarizes the significant achievements of photo-driven theranostics based on AIEgens and elaborates on their diverse theranostic modalities.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Qisong Zhang et al.
Summary: An organic dye emitting in the second near-infrared window with enhanced fluorescence intensity was developed for in vivo bioimaging and biosensing applications, enabling high frame rate imaging.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Nanoscience & Nanotechnology
Liam R. MacFarlane et al.
Summary: pi-Conjugated polymers exhibit diverse electronic and optical properties. This review discusses the preparation of self-assembled nanoparticles from these polymers and their applications in optoelectronics, biomedical imaging and therapy, photocatalysis, and sensing. The development of pi-conjugated polymers has opened up new possibilities for functional organic materials similar to inorganic semiconductors, with nanoparticles based on these polymers showing promise in various emerging applications.
NATURE REVIEWS MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Markus Hecht et al.
Summary: The discovery of the self-assembly of cyanine dyes into J-aggregates had a significant impact on dye chemistry, leading to the emergence of new useful properties. Despite a good theoretical understanding of their structure-property relationships, examples of J-aggregates remained scarce due to the lack of supramolecular designs to guide their formation. The use of nature's supramolecular blueprint in the development of J-aggregates of perylene bisimides (PBIs) has shown promise in various applications, such as high-performance color pigments and organic semiconductors.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dingyuan Yan et al.
Summary: The study successfully constructed highly stable NIR-II AIEgen DPBTA-DPTQ nanoparticles using benzo[c]thiophene as an electron-rich and bulky donor/π-bridge, achieving acceptable fluorescence quantum yield and excellent photothermal conversion efficiency. DPBTA-DPTQ showed good biocompatibility and efficient photothermal therapeutic effects in in vitro tests, demonstrating potential for photothermal eradication of tumors in mouse models.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chia-An Shen et al.
Summary: The supramolecular polymorphism of bis(squaraine) dye aggregates exhibits different structures and absorption properties depending on the cooling rate, with helical nanorods showing panchromatic features and thermodynamically stable nanosheet structures displaying a narrow, bathochromically shifted J-band.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Hongchao Yang et al.
Summary: Alloyed AgAuSe quantum dots exhibit high PLQY and long lifetime in the NIR-II window, showing great potential for applications in bioimaging, LEDs, and photovoltaic devices.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Optics
Zhe Feng et al.
Summary: The study improved the definition of the NIR-II window, proposed the NIR-III window, identified the optical range suitable for in vivo imaging, and provided excellent optical sectioning capability and imaging depth for brain fluorescence microscopy examinations.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Fang Fang et al.
Summary: The development of purely organic thermally activated delayed fluorescence (TADF) materials has brought a breakthrough in the field of organic optoelectronics, especially in the biomedical sector. With unique photophysical properties and reduced health risks, these metal-free TADF luminophores have shown great potential in applications such as fluorescence imaging and photodynamic therapy. The systematic review in this article highlights the importance of TADF materials in biomedicine and discusses future challenges and developments.
Article
Multidisciplinary Sciences
Kang Li et al.
Summary: J-aggregation has been shown to be an effective strategy for developing fluorescent imaging agents in the NIR-II spectral region. However, designing suitable J-aggregates remains challenging. This study demonstrates the J-aggregation of a BODIPY dye with NIR-II emission and its application in lymph node imaging for fluorescence-guided surgery.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiaozhen Li et al.
Summary: Recent progress has been made in developing photothermal agents (PTAs) for biomedical and energy applications. Photochemical synthesis offers a cost-effective and environmentally friendly alternative to traditional methods. The synthesized nonplanar small molecules (NSMs) show promising photophysical properties and excellent photothermal performance, making them suitable for in vivo applications such as photoacoustic imaging and tumor ablation.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chia-An Shen et al.
Summary: A novel bis(squaraine) dye containing two near-infrared dyes is able to emit fluorescence at 961-971 nm in chloroform and self-assemble into nanofibers in toluene, resulting in another bathochromic shift at 1095-1116 nm.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Cayla A. Wood et al.
Summary: Photoacoustic imaging is enhanced by the development of a contrast agent based on targeted liposomes loaded with J-aggregated indocyanine green dye, which provides improved contrast-agent quantification/sensitivity and SO2 estimation accuracy compared to monomeric ICG, making it a promising agent for future clinical molecular PA imaging.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Shuai Xu et al.
Summary: J-aggregates are interesting fluorophore aggregates formed by highly ordered assembled organic dyes, with narrow and red-shifted optical properties, attracting attention in biomedical applications for improved light absorptivity and effective biological imaging or therapeutic purposes.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Xiaozhen Li et al.
Summary: The synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT) shows superior clinical application prospects compared to single PDT or PTT. By designing and synthesizing a near-infrared (NIR) small molecule (ETTC), multiple functions such as NIR-II fluorescence imaging, photoacoustic imaging, PTT, and PDT were successfully achieved and optimized. This work provides a novel perspective for the development of efficient and versatile biomedical applications in a single molecule.
NANOSCALE HORIZONS
(2021)
Review
Chemistry, Multidisciplinary
Luyang Zhao et al.
Summary: This review focuses on J-aggregated organic dye materials with super-large red-shifted absorption, which is mainly attributed to intermolecular charge transfer between neighboring chromophores. By finely tuning the molecular structure or kinetic assembly process, materials with super-large red-shift can be obtained and have been successfully applied in biological imaging, phototherapy, electronic devices, and solar cells, showing great potential in various fields.
Article
Chemistry, Multidisciplinary
Shunjie Liu et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Biomedical
Zhenhua Hu et al.
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Multidisciplinary Sciences
Yuanyuan Li et al.
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Yingpeng Wan et al.
Review
Chemistry, Multidisciplinary
Haoke Zhang et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Shengliang Li et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Christopher R. Benson et al.
Article
Chemistry, Multidisciplinary
Shunjie Liu et al.
Article
Chemistry, Multidisciplinary
Shunjie Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Physical
Arundhati P. Deshmukh et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Emily D. Cosco et al.
Review
Chemistry, Multidisciplinary
Guangxue Feng et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Multidisciplinary Sciences
Shangfeng Wang et al.
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Zheng Zhao et al.
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Yingpeng Wan et al.
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Wei Chen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Caixia Sun et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Meihui Su et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Review
Chemistry, Multidisciplinary
Jingchao Li et al.
CHEMICAL SOCIETY REVIEWS
(2019)
Review
Chemistry, Multidisciplinary
Nicholas J. Hestand et al.
Article
Nanoscience & Nanotechnology
Yong Fan et al.
NATURE NANOTECHNOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Pengfei Sun et al.
CHEMICAL COMMUNICATIONS
(2018)
Review
Engineering, Biomedical
Guosong Hong et al.
NATURE BIOMEDICAL ENGINEERING
(2017)
Review
Chemistry, Multidisciplinary
Nicholas J. Hestand et al.
ACCOUNTS OF CHEMICAL RESEARCH
(2017)
Article
Chemistry, Multidisciplinary
Tian Lu et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2012)
Review
Chemistry, Multidisciplinary
Frank Wuerthner et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2011)
Article
Multidisciplinary Sciences
Kevin Welsher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
