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Article
Chemistry, Multidisciplinary
Wenhui Jia et al.
Summary: This study presents a brain-targeted nanoplatform for glioblastoma multiforme (GBM) treatment, which manipulates autophagy and cuproptosis. The nanoplatform utilizes transferrin receptor-mediated active targeting and pH-responsive delivery to achieve site-specific delivery of regorafenib. By inhibiting autophagosome-lysosome fusion, regorafenib induces lethal autophagy arrest in GBM cells. Additionally, Cu2+ is utilized to facilitate the encapsulation of regorafenib and trigger cuproptosis, resulting in a synergistic effect with regorafenib against GBM.
Article
Chemistry, Multidisciplinary
Lingpu Zhang et al.
Summary: This study reports a prodrug that releases Camptothecin (CPT) in response to glutathione (GSH), aiming to improve its bioavailability and reduce systemic toxicity. By incorporating the prodrug into nanoparticles, it enhances tumor targeting ability and therapeutic efficacy of CPT, as well as promotes immune cell activation and tumor infiltration.
Article
Engineering, Biomedical
Yun Huang et al.
Summary: This article proposes a strategy to maximize the immunogenic cell death (ICD) effect of oxaliplatin (OXA) by combining it with nanoparticles containing a platinum (IV) prodrug (Pt(IV)-C16) and a near-infrared II (NIR-II) photothermal agent (IR1061). Under NIR-II light irradiation, these nanoparticles significantly improve the anti-cancer efficacy against triple-negative breast cancer 4T1 tumor, compared to OXA or IR1061 alone.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yingjie Yu et al.
Summary: This study visualizes the involvement of the DNA repair enzyme APE1 in platinum drug resistance in living cells using a DNA tetrahedron-based molecular probe. It also demonstrates the suppression of APE1 expression in cancer cells using a DNA tetrahedron-based RNA interference technique, presenting a novel strategy to overcome platinum drug resistance.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lingpu Zhang et al.
Summary: This article reports a novel approach for treating metastatic tumors by combining highly efficient chemotherapy drugs with DNA nanostructures that activate immune responses. The DNA nanostructures can not only serve as drug delivery carriers, but also stimulate the STING pathway for antitumor immune responses. In a mouse breast cancer model, the nanostructures were able to effectively eradicate both primary and metastatic tumors, demonstrating their potential for clinical translation.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jie Zhou et al.
Summary: In this study, a photothermally triggered nanoplatform (Au@MSN-Cu/PEG/DSF) was constructed to achieve synergistic therapy and overcome the challenges in cancer treatment. The platform released DSF to chelate with Cu2+ and generate highly cytotoxic CuET, inducing cell apoptosis. The Cu+ species formed further promoted toxic mitochondrial protein aggregation, leading to cell cuproptosis. With the combination of photothermal therapy, Au@MSN-Cu/PEG/DSF effectively killed tumor cells and inhibited tumor growth.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Oncology
Rebecca L. Siegel et al.
Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Chemistry, Multidisciplinary
Yingjie Yu et al.
Summary: Photothermal therapy shows great potential for cancer treatment due to its effective tumor ablation and minimal invasiveness. This study introduces a new class of biodegradable photothermal agents that effectively absorb near-infrared light for deep tumor therapy, demonstrating successful results in a deep-seated ovarian cancer model. This work paves the way for the design of more effective photothermal agents.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Feixiang Ding et al.
Summary: Recent progress in studying copper-dependent targets and pathways in tumor treatment has provided new insights into leveraging copper-dependent disease vulnerabilities and manipulation of intratumor copper transportation. Researchers developed ROS-sensitive nanoparticles loaded with copper chaperone inhibitor DC_AC50 and cisplatin(IV) prodrug, which enhanced the chemotherapeutic effect of cisplatin, induced significant ROS generation, and facilitated immunogenic cell death (ICD) for sustained immune response.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Immunology
Brendan W. MacNabb et al.
Summary: This study demonstrates the importance of MHC-I cross-dressing in regulating anti-tumor immunity. In addition to quantitatively enhancing tumor antigen presentation, it also enables dendritic cells to more accurately mirror the cancer cell peptidome.
Editorial Material
Biochemistry & Molecular Biology
Paul A. Cobine et al.
Summary: Tsvetkov et al. (2022) identified a novel form of cell death caused by targeted accumulation of Cu in mitochondria, which leads to aggregation of lipoylated TCA cycle enzymes through direct Cu binding.
Editorial Material
Multidisciplinary Sciences
Martha A. Kahison et al.
Article
Multidisciplinary Sciences
Peter Tsvetkov et al.
Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.
Review
Chemistry, Multidisciplinary
Wei-Hai Chen et al.
Summary: This review summarizes the recent advances in the synthesis and application of biomedical polymers, discussing their property-function relationship for corresponding biomedical applications. It highlights emerging bioactive polymers as potential biomaterials for cancer precision therapy. The challenges and outlook for the development of more efficient, healthier, and safer biomedical polymers are also discussed.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Oncology
Yuan-Yuan Qu et al.
Summary: Camrelizumab plus famitinib demonstrated potent antitumor activity in advanced or metastatic urothelial carcinoma patients after platinum-based chemotherapy. Patients with bladder cancer seemed to have a better response to this combination therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Xuhui Tong et al.
Summary: This article discusses the molecular processes and effects of necroptosis, pyroptosis, ferroptosis, and cuproptosis on tumor cell proliferation and cancer metastasis, as well as the complex effects of these novel types of tumor cell death on the tumor microenvironment and regulated death of other cells in the microenvironment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weijun Xu et al.
Summary: Cuproptosis is a newly recognized regulated cell death mechanism that shows promise in cancer treatment. A novel copper/iron hybrid hollow metal organic framework (HaMOF) is developed for synergistic anticancer therapy by amplifying oxidative stress and disrupting copper/iron metabolism. The bimetallic hollow nanoplatform induces potent ferroptosis and cuproptosis, and efficiently suppresses tumor growth.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Dongsheng Tang et al.
Summary: This study reports a self-sacrificially degradable pseudo-semiconducting polymer (PSP) for NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT). The PSP can co-assemble with a doxorubicin-containing polyester and release the drug at tumor sites, offering potential applications in cancer therapy.
ADVANCED MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Alberto Mantovani et al.
Summary: This review discusses the molecular mechanisms of macrophage reprogramming in the tumor microenvironment and provides an overview of macrophage-targeted therapies for cancer treatment.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Urology & Nephrology
Yu-Cheng Lee et al.
Summary: Bladder cancer is a prevalent but currently understudied cancer type. Current research focuses on the genetic and epigenetic alterations of the bladder, while the role of the stromal compartment receives less attention. The bladder tumor microenvironment and the metastatic tumor microenvironment are important but unexploited niches.
NATURE REVIEWS UROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yongyun Li et al.
Summary: This study reports the discovery of a new inhibitor, elesclomol, for uveal melanoma by transporting copper ions into mitochondria and generating reactive oxygen species in GNAQ/11-mutant cells, which inhibits cell migration and tumor growth.
Article
Biotechnology & Applied Microbiology
Haiqin Song et al.
Summary: Photodynamic therapy combined with chemotherapy and immunotherapy using a triple action cationic porphyrin-cisplatin conjugate showed promising results in this study. The nanoparticles delivered the drugs and generated reactive oxygen species for treatment, while triggering immunogenic cell death cascade. This novel approach has great potential in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lingpu Zhang et al.
Summary: A reduction-sensitive polymer is designed to encapsulate a cationic phenanthriplatin drug into nanoparticles, which can release the drug in cancer cells and induce DNA damage and activate immune responses, improving the efficacy of chemo-immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yuzhi Xu et al.
Summary: Cuproptosis, a copper-dependent form of regulated cell death, offers great opportunities for cancer treatment. In this study, a glucose oxidase (GOx)-engineered nonporous copper(I) 1,2,4-triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], is developed for starvation-augmented cuproptosis and photodynamic synergistic therapy. In vivo experimental results show its effectiveness in inhibiting tumor growth.
ADVANCED MATERIALS
(2022)
Review
Oncology
Peijie Zheng et al.
Summary: Elesclomol is an anticancer drug that targets mitochondrial metabolism to suppress cancer growth. It induces cell death by modulating copper levels and exhibits significant toxicity to various cancer cells. The research progress provides a possibility for the reapplication of Elesclomol and suggests combination therapy with other drugs.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Alessio Lanna et al.
Summary: It was discovered that some T cells can elongate telomeres by acquiring telomere vesicles from antigen-presenting cells, independently of telomerase action, which contributes to delaying the aging process.
NATURE CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Liyun Chen et al.
Summary: Copper is an essential micronutrient that is required for various physiological processes in almost all cell types, and its homeostasis is tightly regulated to avoid oxidative stress and cellular dysfunction. Recent studies have identified a novel form of cell death called cuproptosis, which is induced by copper binding to lipoylated enzymes in the tricarboxylic acid cycle and ultimately leads to protein aggregation, proteotoxic stress, and cell death. This article summarizes current knowledge on copper metabolism, copper-related diseases, the characteristics of cuproptosis, and the regulatory mechanisms involved. The implications of cuproptosis in the pathogenesis of diseases such as Wilson's disease, neurodegenerative diseases, and cancer are also discussed, along with the therapeutic potential of targeting cuproptosis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Oncology
Eva J. Ge et al.
Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.
NATURE REVIEWS CANCER
(2022)
Review
Oncology
Amit Grover et al.
Summary: MDSCs are important regulators of immune responses in cancer, and their association with negative clinical outcomes makes them attractive therapeutic targets. However, the complex nature of MDSC biology presents a substantial challenge for therapeutic targeting. This review discusses the challenges and potential solutions in targeting MDSCs for therapeutic intervention.
Article
Chemistry, Multidisciplinary
Lingna Wang et al.
Summary: A systematic combination strategy utilizing near-infrared light-triggered hyperthermia, combined with cisplatin, was proposed to overcome drug resistance. The strategy showed significant efficacy in inhibiting the growth of multidrug-resistant lung cancer in both in vitro and in vivo studies.
ADVANCED MATERIALS
(2021)
Article
Oncology
Thomas Powles et al.
Summary: The study examined the outcomes of using pembrolizumab alone or combined with chemotherapy as first-line treatment for advanced urothelial carcinoma, and found that the addition of pembrolizumab to platinum-based chemotherapy did not significantly improve efficacy. Safety was assessed and the study concluded that this combination treatment should not be widely adopted for this type of cancer.
Review
Oncology
Bernadett Szabados et al.
Summary: The study summarized the performance of immune checkpoint inhibitors in the treatment of metastatic bladder cancer, showing that monotherapy with immune checkpoint inhibitors is not superior to chemotherapy, and the combination of chemotherapy and immune checkpoint inhibitors may be effective, but the effect is not significant enough.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Article
Oncology
Kohei Kobatake et al.
CLINICAL CANCER RESEARCH
(2020)
Review
Urology & Nephrology
Julieta Afonso et al.
NATURE REVIEWS UROLOGY
(2020)
Article
Medicine, General & Internal
Matthew D. Galsky et al.
Article
Biochemistry & Molecular Biology
David Y. Oh et al.
Article
Oncology
Florida Voli et al.
Article
Biochemistry & Molecular Biology
Jun-Kyu Byun et al.
Review
Chemistry, Inorganic & Nuclear
Valentina Oliveri
COORDINATION CHEMISTRY REVIEWS
(2020)
Article
Multidisciplinary Sciences
Feifei Ren et al.
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Peter Tsvetkov et al.
NATURE CHEMICAL BIOLOGY
(2019)
Review
Urology & Nephrology
Anna K. Schneider et al.
NATURE REVIEWS UROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Zefang Tang et al.
NUCLEIC ACIDS RESEARCH
(2017)
Review
Biochemistry & Molecular Biology
Song Mao et al.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Masazumi Nagai et al.
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
