期刊
ADVANCED FUNCTIONAL MATERIALS
卷 33, 期 21, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202213209
关键词
acceptor-donor-acceptor regulation; conjugated oligomers; photothermal antimicrobial therapy; wound healing
Infectious diseases caused by pathogenic microorganisms can have serious consequences and threaten life. Drug-resistant bacteria have made traditional antibiotics less effective. This study develops conjugated oligomers with tunable backbones for regulating their photo-thermal conversion, which show high photothermal conversion efficiency. The resulting nanoparticles have strong antimicrobial activity against drug-resistant bacteria under near-infrared irradiation, promoting wound healing in diabetic mice. This work provides ideas for designing efficient antimicrobial agents against drug-resistant microbial infections activated by near-infrared.
Infectious diseases (such as wound infections) caused by pathogenic microorganisms can lead to serious consequences and even threaten life. The emergence of drug-resistant bacteria has severely prevented the validity of traditional antibiotics. Therefore, developing novel antimicrobial strategies without drug-resistant holds great promise for maximizing efficacy and minimizing the risk of drug-resistance of resistant bacterial infections. Herein, near-infrared (NIR)-absorbing A-D-A type conjugated oligomers with a tunable backbone are designed and synthesized for regulating their photo-thermal conversion. After being assembled into nanoparticles, the conjugated oligomer CP-F8P nanoparticles (NPs) containing a strong electron-donating component show the strongest photothermal conversion efficiency of 81.6%. The low concentration of CP-F8P NPs receive over 99% of antimicrobial efficiency against Amp((R)) E. coli, S. aureus, and C. albicans upon NIR irradiation, and the phototherapy treatment of CP-F8P NPs can effectively promote wound healing in diabetic mice with good biocompatibility. This work provides ideas for the design of efficient NIR-activated antimicrobial reagents against drug-resistant microbial infections.
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