☆ 4.7 Review

Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment

ADVANCED DRUG DELIVERY REVIEWS (2023)

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Article Engineering, Biomedical

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

Jianhua He et al.

Summary: Nanoparticle-based therapeutics show potential for treating atherosclerosis, but the complex plaque microenvironment hinders their targeting ability. In this study, we developed reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies to overcome this barrier. These nanoassemblies specifically accumulated in atherosclerotic plaque, rapidly disassembled in response to excess ROS, and released smaller nanoparticles for deeper penetration and targeted drug delivery. In vivo studies demonstrated that the nanoassemblies reduced plaque size, lipid deposition, macrophage content, and local inflammatory factor levels, while also alleviating systemic inflammation. Overall, the ROS-responsive and size-reducible nanoassemblies exhibit enhanced targeting ability and provide an effective approach for atherosclerosis therapy.

BIOACTIVE MATERIALS (2023)

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Review Chemistry, Multidisciplinary

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Yishen Liu et al.

Summary: In vivo imaging in the second near-infrared window (NIR-II) has provided great opportunities for biomedical research and clinical applications. This review summarizes the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. The versatile applications and imaging modalities enabled by these advanced fluorescent properties are discussed, along with the challenges and perspectives for future clinical translation to boost the progress of NIR-IIa and NIR-IIb imaging technology.

CHEMICAL REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux

Hongyan Zhou et al.

Summary: The biomimetic membrane-coated Prussian blue nanoparticles (PB NPs) prepared in this study, incorporating Artemisinin (ART) and Procyanidins (PC), showed significant scavenging effect on ROS and NO, while inhibiting NF-kappa B/NLRP3 pathway, and enhancing AMPK/mTOR/autophagy pathway. The improved biocompatibility and immune-escape ability of nanocomplexes allowed high drug accumulation in the atherosclerotic plaque of ApoE-/- mice model, showing high efficacy against atherosclerosis with both low and high dosage treatment.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Atherosclerotic plaque-targeted nanotherapeutics ameliorates atherogenesis by blocking macrophage-driven inflammation

Hui Yang et al.

Summary: This study develops a translational nanosystem using D-mannose modified selenium nanoparticles to inhibit the occurrence and development of atherosclerosis, and demonstrates strong anti-inflammatory effects.

NANO TODAY (2022)

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Article Biochemical Research Methods

Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

Xiangang Huang et al.

Summary: Macrophages play a role in promoting plaque progression in atherosclerosis and are an attractive therapeutic target. Researchers have developed siRNA nanoparticles that can silence CaMKII γ activity in macrophages for the treatment of atherosclerosis.

NATURE PROTOCOLS (2022)

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Review Cardiac & Cardiovascular Systems

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Wei Chen et al.

Summary: Nanotechnology has the potential to improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies. Targeted nanoparticles for macrophages offer more precise imaging and treatment methods. Future directions include accelerating the clinical translation of nanomedicine for the treatment of atherosclerosis.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization

Thomas H. Wurster et al.

Summary: This study assessed the diagnostic potential of [18F]sodium fluoride and gadobutrol enhanced PET/MRI in patients with CAD. The results showed that this dual-probe PET/MRI technique is clinically feasible and has the potential to aid in the identification of high-risk patients, with some improvement in the identification of high-risk plaque features.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2022)

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Article Materials Science, Biomaterials

Hyaluronic acid targeted and pH-responsive multifunctional nanoparticles for chemo-photothermal synergistic therapy of atherosclerosis

Shun Liu et al.

Summary: In this study, a multifunctional drug-loaded nano-delivery system with pH-responsive, CD44-targeted, and chemical-photothermal synergistic treatment was successfully prepared. This system showed excellent drug-controlled release properties in the weakly acidic microenvironment of atherosclerotic inflammation, and exhibited low cytotoxicity against RAW 264.7 cells. The combination of CuS photothermal treatment with anti-atherosclerosis chemotherapy had better effects than single treatment in vitro and in vivo, demonstrating broad application prospects in anti-atherosclerosis.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Biotechnology & Applied Microbiology

Self-oxygenation mesoporous MnO2 nanoparticles with ultra-high drug loading capacity for targeted arteriosclerosis therapy

Weidong Sun et al.

Summary: This study developed a MnO2-based nanomedicine to re-educate macrophages for targeted AS therapy. The nanomedicine exhibited catalase-mimic activity and high drug loading capacity, allowing it to effectively alleviate AS symptoms by repolarizing macrophages and promoting lipid efflux. In a mouse model, the nanosystem significantly enhanced drug accumulation in atherosclerotic lesions and achieved robust anti-AS efficacy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

Black TiO2 nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis

Ting Dai et al.

Summary: This study demonstrates that mild phototherapy, using foam cell-targeted nanoprobes, can effectively reduce intracellular lipid levels in foam cells without inducing apoptosis or necrosis. The protective effect against apoptosis or necrosis is correlated with the upregulation of heat shock protein 27. Additionally, the phototherapy regimen also inhibits intracellular cholesterol biosynthesis, excess cholesterol uptake, and triggers cholesterol efflux, ultimately preventing lipid accumulation in foam cells.

BIOACTIVE MATERIALS (2022)

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Editorial Material Chemistry, Multidisciplinary

Theranostic Nanomedicine in the NIR-II Window: Classification, Fabrication, and Biomedical Applications

Wei Tao et al.

CHEMICAL REVIEWS (2022)

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Review Cell Biology

Platelets, a Key Cell in Inflammation and Atherosclerosis Progression

Ricardo Huilcaman et al.

Summary: Platelets play important roles in thrombosis-dependent obstructive cardiovascular diseases and also participate in the earliest stages of atherosclerosis, while serving as modulators of inflammation.

CELLS (2022)

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Review Cardiac & Cardiovascular Systems

Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms

Yuzhou Gui et al.

Summary: Foam cells play a vital role in atherosclerosis and are derived from multiple cell types. Novel technologies have improved our understanding of different subtypes of foam cells. Foam cells undergo various cell death pathways, affecting plaque formation. Cholesterol uptake, efflux, and esterification are crucial for foam cell formation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Nanoscience & Nanotechnology

Targeted Therapy of Atherosclerosis Vulnerable Plaque by ROS-Scavenging Nanoparticles and MR/Fluorescence Dual-Modality Imaging Tracing

Yue Dai et al.

Summary: In this study, integrated diagnosis and treatment nanoparticles based on Gd-doped Prussian blue (GPB) were developed for the fluorescence/MR dual-mode imaging and anti-ROS treatment of vulnerable atherosclerosis (AS) plaques. The fabricated nanoparticles showed excellent imaging ability and effectively inhibited AS progression by scavenging ROS, reducing inflammation, apoptosis, and the formation of foam cells. This study provides a new avenue for the diagnosis and treatment of vulnerable AS plaques.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Chemistry, Multidisciplinary

Macrophage-Targeted Sonodynamic/Photothermal Synergistic Therapy for Preventing Atherosclerotic Plaque Progression Using CuS/TiO2 Heterostructured Nanosheets

Zhengyu Cao et al.

Summary: Sonodynamic therapy (SDT) and photothermal therapy (PTT) are combined using hyaluronic acid and PEG-modified copper sulfide/titanium oxide heterostructure nanosheets to target and treat early atherosclerotic plaques. The synergistic therapy induces apoptosis of proinflammatory macrophages, reduces heat shock protein 90 expression, and mitigates inflammation, preventing plaque progression.

ACS NANO (2022)

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Article Engineering, Biomedical

Multifunctional light-activatable nanocomplex conducting temperate-heat photothermal therapy to avert excessive inflammation and trigger augmented immunotherapy

Lu Li et al.

Summary: This study reports a multifunctional light-activatable nanocomplex that avoids hyperthermia and achieves temperate-heat photothermal therapy (PTT) to induce extensive apoptosis, enhance anti-tumor immune response, and inhibit tumor metastasis and recurrence. The nanocomplex maintains a specific temperature upon near-infrared irradiation, allowing controlled drug release to disrupt the thermoresistance of tumor cells. Additionally, it promotes tumor perfusion of dendritic cells (DCs) and T lymphocytes, alleviates the immunosuppressive microenvironment, and elicits a strong systemic immune response.

BIOMATERIALS (2022)

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Article Clinical Neurology

Rosuvastatin Slows Progression of Carotic Intima-Media Thickness: The METEOR-China Randomized Controlled Study

Huaguang Zheng et al.

Summary: This study demonstrates that rosuvastatin significantly reduces the progression of CIMT in Chinese adults with subclinical atherosclerosis and is well tolerated. The findings contribute to a deeper understanding of atherosclerosis and provide guidance for clinical practice.

STROKE (2022)

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Article Medicine, Research & Experimental

Inflammatory endothelium-targeted and cathepsin responsive nanoparticles are effective against atherosclerosis

Fei Fang et al.

Summary: Targeted and responsive nanoparticles can control the release of drugs and effectively treat atherosclerosis. In vitro experiments showed that these nanoparticles can rapidly release drugs in response to stimulation and effectively inhibit inflammatory responses. In vivo experiments showed that these nanoparticles can slow down the progression of atherosclerosis and reduce inflammation.

THERANOSTICS (2022)

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Review Chemistry, Multidisciplinary

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Jiang Ouyang et al.

Summary: Traditional treatments like chemotherapy and surgery often have severe side effects and cause pain. The emergence of nanomedicines and minimally invasive therapies has brought hope to patients with malignant diseases. Minimally invasive nanomedicines combine the advantages of nanomedicines and minimally invasive therapies, effectively targeting pathological cells and minimizing side effects. This review provides a comprehensive overview of the research status and challenges of minimally invasive nanomedicines and their applications in various fields.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Biochemistry & Molecular Biology

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Peng Kong et al.

Summary: Atherosclerosis is a chronic inflammatory vascular disease that can be promoted or inhibited by innate and adaptive immune responses. Several signaling pathways associated with the inflammatory response have been found to play important roles in the development and regression of atherosclerosis. Targeting inflammatory pathways may represent a new approach for the treatment of atherosclerotic diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Biochemistry & Molecular Biology

Pathophysiology of Atherosclerosis

Shifa Jebari-Benslaiman et al.

Summary: This article provides an overview of the development of atherosclerosis and discusses the regulatory role of microRNAs and lncRNAs, the role of the microbiota, and the importance of sex as a risk factor.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pediatrics

The role of integrins in inflammation and angiogenesis

Olachi J. Mezu-Ndubuisi et al.

Summary: Integrins are heterodimeric receptors composed of alpha and beta subunits, playing crucial roles in cell adhesion, growth, migration, and signaling. Research indicates their promising therapeutic potential in diseases of inflammation, infection, and angiogenesis in infants.

PEDIATRIC RESEARCH (2021)

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Article Engineering, Biomedical

Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis

Le Minh Pham et al.

Summary: This study found that CD9 antibody-modified nanoparticles showed high cellular uptake in vitro models, reducing oxidative stress and inflammation in senescent cells, and improving cell viability. In vivo experiments demonstrated that these nanoparticles effectively targeted senescent areas, delivering anti-senescence drugs to atherosclerotic plaques and alleviating the progression of atherosclerosis. This suggests a novel and precise therapeutic approach for treating atherosclerosis by targeting senescent cells.

BIOMATERIALS (2021)

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Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

Mandy O. J. Grootaert et al.

Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.

CARDIOVASCULAR RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Foam Cells as Therapeutic Targets in Atherosclerosis with a Focus on the Regulatory Roles of Non-Coding RNAs

Amin Javadifar et al.

Summary: This study focuses on the role of foam cells in the development of atherosclerosis, with a special emphasis on non-coding RNAs and their regulation of lipid metabolism, inflammatory pathways, and foam cell formation. Important preclinical evidence is reviewed regarding therapeutic targeting of non-coding RNAs in atherosclerosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

Iron Oxide Nanoparticle Uptake in Mouse Brachiocephalic Artery Atherosclerotic Plaque Quantified by T2-Mapping MRI

Rik P. M. Moonen et al.

Summary: The study monitored iron oxide contrast agent uptake in mouse atherosclerotic plaques using quantitative T-2-mapping MRI, finding an inverse relationship between T-2 values and iron levels in the plaque.

PHARMACEUTICS (2021)

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Article Biotechnology & Applied Microbiology

LDL-Based Lipid Nanoparticle Derived for Blood Plasma Accumulates Preferentially in Atherosclerotic Plaque

Christian A. Boada et al.

Summary: Apolipoprotein-based drug delivery using lipid-based nanoparticles called Aposomes shows promising potential for targeted drug delivery. These Aposomes, with native apoB-100 protein on the surface, demonstrated active drug loading capabilities and enhanced targeting towards atherosclerotic plaques in a mouse model. The study highlights the feasibility of utilizing apolipoprotein-based approaches to create nanoparticles with active targeting capabilities for potential cardiovascular therapies.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Targeting inflammation in atherosclerosis - from experimental insights to the clinic

Oliver Soehnlein et al.

Summary: Inflammation plays a substantial role in atherosclerosis and targeting inflammatory pathways could provide a promising new avenue to prevent and treat the disease. Clinical studies have shown that modulation of inflammation can help prevent the clinical complications of atherosclerosis. Refining strategies for combatting inflammation in the disease is crucial for further progress in managing atherosclerotic risk.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Chemistry, Multidisciplinary

Palladium Hydride Nanopocket Cubes and Their H2-Therapy Function in Amplifying Inhibition of Foam Cells to Attenuate Atherosclerosis

Min Xu et al.

Summary: In this study, a coupling hardness with softness strategy utilizing palladium hydride nanopocket cubes was developed for the first time to regulate lipid uptake and efflux, resulting in the inhibition of foam cell formation and reduction of atherosclerosis. This approach shows promise as a high efficacy and low toxicity method for treating atherosclerosis.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe

Khanh Ha et al.

Summary: The study developed a near-infrared fluorescence probe based on tirofiban, which can rapidly and accurately visualize activated platelets in vivo, offering a potential new application for clinical diagnosis.

ACS SENSORS (2021)

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Article Pharmacology & Pharmacy

Development of Dextran-Coated Magnetic Nanoparticles Loaded with Protocatechuic Acid for Vascular Inflammation Therapy

Maria Anghelache et al.

Summary: This study developed dextran shell-iron oxide core nanoparticles loaded with protocatechuic acid (PCA) and evaluated their anti-inflammatory potential at non-cytotoxic and therapeutically relevant concentrations. The results showed that MNP-Dex/PCA reduced inflammatory molecules levels in activated endothelial cells and M1-type macrophages, along with decreased monocyte adhesion, through the modulation of ERK1/2, p38-alpha MAPKs, and NF-kB signaling pathways. These findings support the future development of dextran shell-magnetic core nanoparticles as theranostic tools for vascular inflammation therapy.

PHARMACEUTICS (2021)

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Article Medicine, Research & Experimental

HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the GATA6 promoter

Chengxiu Hu et al.

Summary: This study demonstrated that Romidepsin modulates VCAM-1 expression to attenuate atherosclerosis by inhibiting HDAC1/2, leading to reduced GATA6 expression and enhanced STAT3 acetylation. Romidepsin was shown to reduce atherosclerotic lesion development by affecting GATA6 methylation in experiments, highlighting the potential therapeutic effect of targeting HDAC1/2 in atherosclerotic heart disease.

THERANOSTICS (2021)

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Article Chemistry, Multidisciplinary

An intelligent T1-T2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques

Chunshu Pan et al.

Summary: The study proposes a macrophage-targeted and in situ stimuli-triggered T-1-T-2 switchable magnetic resonance imaging (MRI) nanoprobe for non-invasive diagnosis of vulnerable plaques, which can help identify vulnerable plaques at early stages. By modifying and transforming iron oxide nanoparticles, the nanoprobe achieves a substantial non-invasive diagnosis of vulnerable plaques, contributing significantly to the application of materials science in solving clinical problems.

NANOSCALE (2021)

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Article Medicine, Research & Experimental

Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles

Wei Tong et al.

Summary: The novel multimodal imaging platform targeting active myeloperoxidase showed promising results in sensitively differentiating and accurately localizing vulnerable atherosclerotic plaques in vivo. This approach may serve as a method for detecting vulnerable plaques and monitoring inflammation activity related to atherosclerosis.

THERANOSTICS (2021)

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Review Cardiac & Cardiovascular Systems

Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

Celine Souilhol et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Article Engineering, Biomedical

Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E-/- mice

Manse Kim et al.

BIOMATERIALS (2020)

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Review Cardiac & Cardiovascular Systems

The choice of targets and ligands for site-specific delivery of nanomedicine to atherosclerosis

Adil Zia et al.

CARDIOVASCULAR RESEARCH (2020)

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Review Medicine, General & Internal

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

S. Holm Nielsen et al.

JOURNAL OF INTERNAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

CD9 induces cellular senescence and aggravates atherosclerotic plaque formation

Jung Hee Cho et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Biotechnology & Applied Microbiology

Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis

Shuihua Zhang et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Therapeutic Nanoparticles and Their Targeted Delivery Applications

Abuzer Alp Yetisgin et al.

MOLECULES (2020)

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siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

Wei Tao et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Immunology

Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation

Vitaly Sorokin et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Engineering, Biomedical

Nanoparticle-based Two-pronged approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux

Hongliang He et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Effective atherosclerotic plaque inflammation inhibition with targeted drug delivery by hyaluronan conjugated atorvastatin nanoparticles

Seyedmehdi Hossaini Nasr et al.

NANOSCALE (2020)

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Article Chemistry, Multidisciplinary

IL-6-targeted ultrasmall superparamagnetic iron oxide nanoparticles for optimized MRI detection of atherosclerotic vulnerable plaques in rabbits

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RSC ADVANCES (2020)

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Review Materials Science, Biomaterials

Applications of inorganic nanoparticles in the diagnosis and therapy of atherosclerosis

Ting Dai et al.

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Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe

Qiuzhe Wei et al.

ACTA BIOMATERIALIA (2019)

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Article Nanoscience & Nanotechnology

Scavenger receptor-AI-targeted ultrasmall gold nanoclusters facilitate in vivo MR and ex vivo fluorescence dual-modality visualization of vulnerable atherosclerotic plaques

Jiahui Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Vascular smooth muscle cells in atherosclerosis

Gemma L. Basatemur et al.

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Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Patricia Marchio et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions

Wan Xu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Nanoscience & Nanotechnology

Differential Phagocytosis-Based Photothermal Ablation of Inflammatory Macrophages in Atherosclerotic Disease

Xin Wang et al.

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Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe

Yabin Wang et al.

BIOMATERIALS (2019)

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Article Biochemistry & Molecular Biology

Terminalia Arjuna bark extract impedes foam cell formation and promotes apoptosis in ox-LDL-stimulated macrophages by enhancing UPR-CHOP pathway

Shipra Bhansali et al.

LIPIDS IN HEALTH AND DISEASE (2019)

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Article Nanoscience & Nanotechnology

Promoting the Delivery of Nanoparticles to Atherosclerotic Plaques by DNA Coating

Lei Zhang et al.

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Vascular Macrophages in Atherosclerosis

Hailin Xu et al.

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Shahla Korani et al.

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Hyaluronic Acid-Functionalized Gadolinium Doped Iron Oxide Nanoparticles for Atherosclerosis-Targeted Mr Imaging

Ming Yu et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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Article Medicine, Research & Experimental

Intelligent gold nanostars for in vivo CT imaging and catalase-enhanced synergistic photodynamic & photothermal tumor therapy

Lin Zhang et al.

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Article Oncology

Interleukin-1 Blockade in Cardiovascular Diseases: From Bench to Bedside

Leo F. Buckley et al.

BIODRUGS (2018)

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Review Pathology

Potential of anti-inflammatory agents for treatment of atherosclerosis

Dimitry A. Chistiakov et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2018)

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Article Chemistry, Multidisciplinary

Comparison of in vivo targeting ability between cRGD and collagen-targeting peptide conjugated nano-carriers for atherosclerosis

Manse Kim et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Biotechnology & Applied Microbiology

Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development

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MOLECULAR THERAPY (2018)

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Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis

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Magnetic Nanoparticles Conjugated with Peptides Derived from Monocyte Chemoattractant Protein-1 as a Tool for Targeting Atherosclerosis

Chung-Wei Kao et al.

PHARMACEUTICS (2018)

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Article Medicine, Research & Experimental

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches

Julian Bejarano et al.

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Editorial Material Cardiac & Cardiovascular Systems

Atherosclerosis A Chronic Inflammatory Disease With an Autoimmune Component

Kouji Kobiyama et al.

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Article Biotechnology & Applied Microbiology

Hybrid, metal oxide-peptide amphiphile micelles for molecular magnetic resonance imaging of atherosclerosis

Christopher Poon et al.

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Article Chemistry, Multidisciplinary

Identifying macrophage enrichment in atherosclerotic plaques by targeting dual-modal US imaging/MRI based on biodegradable Fe-doped hollow silica nanospheres conjugated with anti-CD68 antibody

Ri Ji et al.

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Nanoparticle Functionalization with Platelet Membrane Enables Multifactored Biological Targeting and Detection of Atherosclerosis

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Jonathan Noonan et al.

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Meng-Yu Wu et al.

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Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-kappa B pathways in macrophages

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The immunology of atherosclerosis

Anton Gistera et al.

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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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Multimodality Imaging of Angiogenesis in a Rabbit Atherosclerotic Model by GEBP11 Peptide Targeted Nanoparticles

Tao Su et al.

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Article Cell & Tissue Engineering

Fluorescence Imaging of Foamy Macrophages by Scavenger Receptor-AI (SR-AI) Targeted Quantum Dots

Qi Guo et al.

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Angiogenesis in the atherosclerotic plaque

Caroline Camare et al.

REDOX BIOLOGY (2017)

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Review Peripheral Vascular Disease

Oxidative Stress in Atherosclerosis

Ajoe John Kattoor et al.

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Article Engineering, Biomedical

Molecular imaging of activated platelets via antibody-targeted ultrasmall iron oxide nanoparticles displaying unique dual MRI contrast

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MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)

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CLINICAL AND TRANSLATIONAL MEDICINE (2017)

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Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes

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Nanoparticles in practice for molecular-imaging applications: An overview

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ACTA BIOMATERIALIA (2016)

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Gold nanoparticles-based SPECT/CT imaging probe targeting for vulnerable atherosclerosis plaques

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Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

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BIOMATERIALS (2016)

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NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1

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CIRCULATION RESEARCH (2016)

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Vascular Smooth Muscle Cells in Atherosclerosis

Martin R. Bennett et al.

CIRCULATION RESEARCH (2016)

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Imaging atherosclerosis with positron emission tomography

Philip Joseph et al.

EUROPEAN HEART JOURNAL (2016)

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Review Medicine, General & Internal

Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions A Systematic Review and Meta-analysis

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Gold Nanoparticles Compromise TNF-α-Induced Endothelial Cell Adhesion Molecule Expression Through NF-κB and Protein Degradation Pathways and Reduce Neointima Formation in a Rat Carotid Balloon Injury Model

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Review Cell Biology

Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage

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Clinically Approved Nanoparticle Imaging Agents

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Integrin-based therapeutics: biological basis, clinical use and new drugs

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NATURE REVIEWS DRUG DISCOVERY (2016)

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Novel nanostructural contrast for magnetic resonance imaging of endothelial inflammation: targeting SPIONs to vascular endothelium

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In vivo MR and Fluorescence Dual-modality Imaging of Atherosclerosis Characteristics in Mice Using Profilin-1 Targeted Magnetic Nanoparticles

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αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice

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EJNMMI RESEARCH (2016)

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Detection of Vulnerable Atherosclerosis Plaques with a Dual-Modal Single-Photon-Emission Computed Tomography/Magnetic Resonance Imaging Probe Targeting Apoptotic Macrophages

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Hyaluronic acid nanoparticles for active targeting atherosclerosis

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Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

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CYTOKINE & GROWTH FACTOR REVIEWS (2015)

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Changes in transcriptome of macrophages in atherosclerosis

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Nanoparticles functionalised with an anti-platelet human antibody for in vivo detection of atherosclerotic plaque by magnetic resonance imaging

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Silica-gold nanoparticles for atheroprotective management of plaques: results of the NANOM-FIM trial

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NANOSCALE (2015)

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Targeted gold-coated iron oxide nanoparticles for CD163 detection in atherosclerosis by MRI

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SCIENTIFIC REPORTS (2015)

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Macrophage subsets in atherosclerosis

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Mechanoresponsive Networks Controlling Vascular Inflammation

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy

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BIOMATERIALS (2014)

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Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

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Mechanisms of Plaque Formation and Rupture

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Dual-Modal Magnetic Resonance and Fluorescence Imaging of Atherosclerotic Plaques in Vivo Using VCAM-1 Targeted Tobacco Mosaic Virus

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NANO LETTERS (2014)

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A Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression Profiling

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CIRCULATION RESEARCH (2013)

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MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma

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Role of macrophage scavenger receptors in atherosclerosis

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IMMUNOBIOLOGY (2012)

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OxLDL-targeted iron oxide nanoparticles for in vivo MRI detection of perivascular carotid collar induced atherosclerotic lesions in ApoE-deficient mice

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JOURNAL OF LIPID RESEARCH (2012)

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Review Cardiac & Cardiovascular Systems

Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease

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EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE (2012)

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Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

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ANTIOXIDANTS & REDOX SIGNALING (2011)

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Peritoneal macrophages are distinct from monocytes and adherent macrophages

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ATHEROSCLEROSIS (2011)

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Targeted nanocarriers for imaging and therapy of vascular inflammation

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CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2011)

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Perspectives and opportunities for nanomedicine in the management of atherosclerosis

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NATURE REVIEWS DRUG DISCOVERY (2011)

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A Prospective Natural-History Study of Coronary Atherosclerosis.

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NEW ENGLAND JOURNAL OF MEDICINE (2011)

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MRI of inducible P-selectin expression in human activated platelets involved in the early stages of atherosclerosis

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NMR IN BIOMEDICINE (2011)

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Review Biochemistry & Molecular Biology

Atherosclerotic lesions in mouse and man: is it the same disease?

Jacob Fog Bentzon et al.

CURRENT OPINION IN LIPIDOLOGY (2010)

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Profilin-1 Is Expressed in Human Atherosclerotic Plaques and Induces Atherogenic Effects on Vascular Smooth Muscle Cells

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PLOS ONE (2010)

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Article Cardiac & Cardiovascular Systems

Adenosine Stress 64- and 256-Row Detector Computed Tomography Angiography and Perfusion Imaging A Pilot Study Evaluating the Transmural Extent of Perfusion Abnormalities to Predict Atherosclerosis Causing Myocardial Ischemia

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Review Biochemistry & Molecular Biology

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

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JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2009)

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Review Cardiac & Cardiovascular Systems

Near-infrared fluorescent probes for imaging vascular pathophysiology

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BASIC RESEARCH IN CARDIOLOGY (2008)

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Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis

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CIRCULATION (2008)

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MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

Anthony J. Muslin

CLINICAL SCIENCE (2008)

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Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using positive contrast magnetic resonance imaging

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)

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P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

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Review Radiology, Nuclear Medicine & Medical Imaging

Molecular imaging and therapy of atherosclerosis with targeted nanoparticles

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JOURNAL OF MAGNETIC RESONANCE IMAGING (2007)

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Review Medicine, General & Internal

Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis?

D. J. Preiss et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2007)

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Review Hematology

Scavenger receptors in atherosclerosis: Beyond lipid uptake

Kathryn J. Moore et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Review Cardiac & Cardiovascular Systems

Neovascularization in human atherosclerosis

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CIRCULATION (2006)

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Article Cardiac & Cardiovascular Systems

Matrix metalloproteinases in cardiovascular disease

Peter Liu et al.

CANADIAN JOURNAL OF CARDIOLOGY (2006)

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Atherosclerotic lesions in the common coronary arteries of ApoE knockout mice

WC Hu et al.

CARDIOVASCULAR PATHOLOGY (2005)

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Nuclear factor κB signaling in atherogenesis

MPJ de Winther et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

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In vivo molecular and cellular imaging with quantum dots

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CURRENT OPINION IN BIOTECHNOLOGY (2005)

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Review Biotechnology & Applied Microbiology

The IKKNF-kappa B system: A treasure trove for drug development

M Karin et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

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Review Cardiac & Cardiovascular Systems

Innate and adaptive immunity in the pathogenesis of atherosclerosis

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CIRCULATION RESEARCH (2002)

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Current concepts of the pathogenesis of the acute coronary syndromes

P Libby

CIRCULATION (2001)

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Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes

S Sugiyama et al.

AMERICAN JOURNAL OF PATHOLOGY (2001)

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The role of MCP-1 in atherosclerosis

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STEM CELLS (2000)

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