期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 35, 页码 11299-11305出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b06295
关键词
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资金
- JSPS KAKENHI Grant [JP16H01004]
- Grants-in-Aid for Scientific Research [16H01004] Funding Source: KAKEN
Protecting-group-free transformation is a challenging and important issue in atom-economical organic synthesis. The eta(6)-arene/N-Me-sulfonyldiamine-Ru(II)-BF4 complex-catalyzed asymmetric hydrogenation of 2-substituted unprotected indoles in weakly acidic hexafluoroisopropanol gives optically active indoline compounds with up to >99% ee. Under mild reaction media, halogen atoms and synthetically important protecting groups (e.g., silyl ether, acetal, benzyl ether, and ester) on indoles are maintained, which is advantageous for the synthesis of further complex indoline molecules.
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