Circadian rhythm disruption in critically ill patients

Article Cardiac & Cardiovascular Systems

Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months

Fridolin Steinbeis et al.

Summary: The severity of respiratory failure during COVID-19 is associated with the degree of pulmonary function impairment and respiratory quality of life in the year after acute infection.

RESPIRATORY MEDICINE (2022)

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Review Psychiatry

Melatonin use during pregnancy and lactation: A scoping review of human studies

Tya Vine et al.

Summary: Current clinical studies suggest that the use of exogenous melatonin during pregnancy and breastfeeding is probably safe in humans, although there is a lack of randomized controlled trials examining its efficacy as a treatment for sleep disorders.

BRAZILIAN JOURNAL OF PSYCHIATRY (2022)

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Article Neurosciences

Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats

Widuri Kho et al.

Summary: Dexmedetomidine can prevent cognitive impairments caused by neuroinflammation, possibly through modulation of macroautophagy and miRNA expression.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Circadian molecular clock disruption in chronic pulmonary diseases

Allan Giri et al.

Summary: Circadian clock disruption plays a crucial role in chronic lung diseases, potentially leading to increased oxidative stress, inflammatory regulated autophagy, and altered pulmonary function. Studies have shown that certain clock genes experience alterations at the transcriptional or translational level in chronic pulmonary diseases.

TRENDS IN MOLECULAR MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Foundations of circadian medicine

Achim Kramer et al.

Summary: Circadian medicine, an emerging field, aims to utilize the mechanisms of the circadian clock for clinical diagnosis, treatment, and prevention. While it has significant health benefits over standard care, there are still open questions and challenges in the development of this field.

PLOS BIOLOGY (2022)

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Review Immunology

Neutrophil Recruitment in Pneumococcal Pneumonia

Catherine S. Palmer et al.

Summary: This article summarizes the pathways of neutrophil migration from the bloodstream to the lungs during pneumococcal infection.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Physiology

Time to Train: The Involvement of the Molecular Clock in Exercise Adaptation of Skeletal Muscle

Shivani Mansingh et al.

Summary: Circadian rhythms regulate physiological processes and exercise training improves their disruptions. Molecular clock factors play a role in skeletal muscle adaptation but the mechanisms are not well understood.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Critical Care Medicine

Intermittent feeding and circadian rhythm in critical illness

Imre W. K. Kouw et al.

Summary: This article reviews the disruptors of circadian rhythms during ICU admission and evaluates the potential benefits of intermittent feeding on metabolism and circadian rhythms.

CURRENT OPINION IN CRITICAL CARE (2022)

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Article Neurosciences

Nobiletin Attenuates Anesthesia/Surgery-Induced Neurocognitive Decline by Preserving the Expression of Clock Genes in Mice

Zhuonan Sun et al.

Summary: Postoperative cognitive dysfunction (POCD) is a common and significant issue that affects the prognosis of patients after surgery. Neuroinflammation plays a crucial role in the pathogenesis of POCD. Despite the lack of practical pharmacological strategies for the treatment and prevention of POCD, this study found that the natural polymethoxylated flavone Nobiletin (NOB) may be a candidate for these purposes.

FRONTIERS IN NEUROSCIENCE (2022)

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Review Immunology

The circadian immune system

Chen Wang et al.

Summary: The immune system is regulated by circadian rhythms, and recent advances have identified molecular factors governing these rhythms. The interconnectivity between immune cells and their environment has been found to be highly complex.

SCIENCE IMMUNOLOGY (2022)

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Article Respiratory System

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics

Peter Pennitz et al.

Summary: Single-cell RNA sequencing is important for studying biological processes, especially in lung research. We compared single-cell transcriptomes from six different species' lungs and identified marker genes using integrative approaches. This method helps identify transcriptomic signatures in different species' lung tissue and select appropriate models for future respiratory research.

EUROPEAN RESPIRATORY REVIEW (2022)

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Article Cell Biology

Macrophage circadian rhythms are differentially affected based on stimuli

Sujeewa S. Lellupitiyage Don et al.

Summary: Macrophage polarization state affects their circadian characteristics, with pro-inflammatory (M1) polarization reducing rhythmicity and anti-inflammatory (M2) polarization increasing the period. Conditioned media from breast cancer cells can disrupt circadian rhythms, while macrophage-conditioned media can alter cancer cell circadian rhythms.

INTEGRATIVE BIOLOGY (2022)

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Letter Health Care Sciences & Services

Changes in Mortality in Top 10 Causes of Death from 2011 to 2018

Jamal S. Rana et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Daniel Wendisch et al.

Summary: Analysis of pulmonary immune responses and lung pathology in patients with COVID-19 ARDS revealed an accumulation of profibrotic macrophages and similarities with macrophage populations in idiopathic pulmonary fibrosis. Exposure to SARS-CoV-2 induced a profibrotic phenotype in human monocytes, suggesting a mechanistic link between the virus and fibroproliferative ARDS.

CELL (2021)

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Review Medicine, Research & Experimental

Effects of melatonin on protecting against lung injury (Review)

Weiwei Wang et al.

Summary: Melatonin, secreted from the pineal gland at night, plays multiple roles including anti-inflammatory, antioxidant, and anticancer functions. It has a protective effect on lung diseases such as acute lung injury and chronic obstructive pulmonary disease. Studies suggest that melatonin serves critical roles in apoptosis, anti-ischemic reperfusion injury, and anti-proliferative effects on various cells.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Biology

A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

Jeffrey Haspel et al.

Summary: The article discusses the interactions between the novel coronavirus and the host's circadian clock, as well as the potential severe complications of the disease. The authors speculate on insights that may be gained on circadian rhythms from the pandemic and how this knowledge could be utilized to mitigate the clinical course of COVID-19.

JOURNAL OF BIOLOGICAL RHYTHMS (2021)

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Article Anesthesiology

Association of Delirium during Critical Illness With Mortality: Multicenter Prospective Cohort Study

Christopher G. Hughes et al.

Summary: Delirium during critical illness, particularly the hypoactive subtype, is associated with a nearly 3-fold increased risk of death the following day for patients in the hospital, but not with mortality after hospital discharge up to 1 year. Delirium seems to be a marker of early mortality during critical illness, primarily driven by the hypoactive subtype, with no lasting impact post-discharge.

ANESTHESIA AND ANALGESIA (2021)

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Article Genetics & Heredity

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

Yang Shen et al.

Summary: Recent studies have shown that NF-kappa B plays a significant role in directly regulating the circadian clock, altering clock oscillations in both cells and tissues, as well as in mice. NF-kappa B competes with coregulators like CRY1 and CBP/p300 for BMAL1 binding to affect circadian transcription, linking inflammation to circadian timekeeping.

PLOS GENETICS (2021)

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Article Biology

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

Veronika Lang et al.

Summary: Local circadian clocks play a role in the body's immune response, with light affecting susceptibility to endotoxic shock. Conditional knockout mice showed rhythmic patterns of immune response even without a myeloid clock. This suggests that systemic time cues can orchestrate immune functions.

ELIFE (2021)

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Review Immunology

Circadian Rhythms in Bacterial Sepsis Pathology: What We Know and What We Should Know

Malena Lis Mul Fedele et al.

Summary: Sepsis is a syndrome caused by a deregulated host response to infection, and the circadian system plays a key role in the timing and severity of sepsis. Different outcomes appear to be associated with the expression of the clock gene Bmal1 in the liver and myeloid immune cells. Understanding the role of the circadian system in sepsis pathology could be crucial for improving patient therapies.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Infectious Diseases

Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study

Charlotte Thibeault et al.

Summary: Adequate patient allocation in healthcare systems is crucial for resource management. This study identified risk factors for invasive mechanical ventilation (IMV) in COVID-19 patients, showing shorter symptom duration and a history of hypertension as associated factors. Patients on IMV had different viral kinetics and longer hospitalization compared to non-IMV patients.

INFECTION (2021)

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Article Multidisciplinary Sciences

Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

Sarah S. Geiger et al.

Summary: The time of day influences immune responses and lethality in response to LPS, with the highest survival rate at the beginning of the light cycle. Feeding, rather than light, is shown to control time-of-day dependent LPS sensitivity through liver clock and hepatic FXR signaling.

NATURE COMMUNICATIONS (2021)

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Article Critical Care Medicine

Circadian rhythms in septic shock patients

Gunnar Lachmann et al.

Summary: Molecular rhythms in immune cells of septic shock patients were substantially altered and decreased compared to healthy young men. The decrease in rhythmicity was clock gene-dependent. The loss of rhythmicity and down-regulation of clock gene expression might be caused by sepsis and might further deteriorate immune responses and organ injury, but further studies are necessary to understand underlying pathophysiological mechanisms.

ANNALS OF INTENSIVE CARE (2021)

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Article Medicine, General & Internal

Pneumonia

Antoni Torres et al.

Summary: Pneumonia is a common acute respiratory infection that affects individuals of all ages globally, causing high morbidity and mortality. It can be caused by various microorganisms, and timely identification of causative pathogens is crucial for effective treatment. New therapies and diagnostic tests are being developed to improve the management of pneumonia.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Medicine, General & Internal

Comparison of sequential feeding and continuous feeding on the blood glucose of critically ill patients: a non-inferiority randomized controlled trial

Chang-Jie Ren et al.

Summary: In this non-inferiority study, the average blood glucose in SF was not inferior to that in CF. The incidence of hyperglycemia was higher in the CF group than in the SF group. There was no significant difference in feeding intolerance between SF and CF.

CHINESE MEDICAL JOURNAL (2021)

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Review Nutrition & Dietetics

Intermittent fasting in paediatric critical illness: The properties and potential beneficial effects of an overnight fast in the PICU

Karlien Veldscholte et al.

Summary: Intermittent fasting has been shown to have potential health benefits in both animal and human studies, including stimulation of various cellular pathways, preservation of brain function, and promotion of cell function and integrity. Future studies should explore its practical implications in critically ill children and determine the optimal duration of fasting periods.

CLINICAL NUTRITION (2021)

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Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

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Article Biochemistry & Molecular Biology

The histone methyltransferase Ezh2 restrains macrophage inflammatory responses

Gareth B. Kitchen et al.

Summary: Robust inflammatory responses are crucial for survival after respiratory infections, and Epigenetic factors are increasingly being recognized as important determinants of immune responses. EZH2 acts differently in macrophages and neutrophils, affecting inflammatory responses and chemotaxis. Targeting EZH2 may have implications for mucosal immunity and conditions driven by pulmonary neutrophil influx.

FASEB JOURNAL (2021)

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Article Medicine, General & Internal

Community-acquired pneumonia

Stefano Aliberti et al.

LANCET (2021)

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Article Immunology

Daytime variation in SARS-CoV-2 infection and cytokine production

Aissatou Bailo Diallo et al.

Summary: The study revealed that the time of day of SARS-CoV-2 infection affects viral infection and host immune response, suggesting that circadian rhythm should be considered in the progression of SARS-CoV-2 disease.

MICROBIAL PATHOGENESIS (2021)

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Article Multidisciplinary Sciences

The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles

Frank A. J. L. Scheer et al.

Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

Anna-Marie Finger et al.

Summary: This study reveals an unknown mechanism for peripheral clock synchrony, showing that transforming growth factor-beta (TGF-beta) plays a crucial role in coupling peripheral oscillators through paracrine pathways. Disruption of TGF-beta signaling causes desynchronization of oscillator networks, resulting in reduced amplitude and increased sensitivity towards external zeitgebers. This has implications for rhythmic organ functions and circadian health.

SCIENCE ADVANCES (2021)

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Article Medicine, Research & Experimental

Molecular clock REV-ERBα regulates cigarette smoke-induced pulmonary inflammation and epithelial-mesenchymal transition

Qixin Wang et al.

Summary: This study investigated the role of REV-ERBα in circadian dysfunction and EMT alteration induced by cigarette smoke. The results showed that REV-ERBα agonist could alleviate CS-induced inflammation and abnormal EMT in the lungs, suggesting activation of REV-ERBα as a potential novel therapeutic approach for smoking-induced chronic inflammatory lung diseases.

JCI INSIGHT (2021)

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Article Multidisciplinary Sciences

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

Xiaodong Zhuang et al.

Summary: The study reveals that the circadian clock can impact SARS-CoV-2 infection, as silencing Bmal1 or treating lung epithelial cells with SR9009 can reduce viral replication. This finding suggests alternative approaches for understanding and improving therapeutic targeting of the virus.

ISCIENCE (2021)

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Review Biochemistry & Molecular Biology

Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

Kenneth Maiese

Summary: Recent research on biological clock genes controlling circadian rhythm offers hope for treating dementia and cognitive loss, with potential benefits including neuroprotection, metabolic homeostasis, and prevention of cognitive decline. Further understanding the complex relationships among these pathways is crucial for desired clinical outcomes.

FRONTIERS IN BIOSCIENCE-LANDMARK (2021)

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Article Endocrinology & Metabolism

The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding

Gal Manella et al.

Summary: The study reveals that the hierarchy between the central and peripheral clocks in mammals has been established, and explores the disparities in responses of peripheral clocks using altered feeding paradigms and liver-clock mutant mice. Despite its significant role in nutrient processing, disruption of the liver-clock does not affect the rhythmicity of other peripheral tissues.

NATURE METABOLISM (2021)

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Article Cardiac & Cardiovascular Systems

Circadian rhythm in critically ill patients: Insights from the eICU Database

Sebastian E. Beyer et al.

Summary: The study investigated circadian variation among critically ill patients in the ICU and its association with clinical characteristics and survival to hospital discharge. Results showed that sicker patients and those on mechanical ventilation, vasopressors, or inotropes have a dampened and phase-shifted 24-hour rhythm, which is associated with longer lengths of stay and higher in-hospital mortality. Higher blood pressure amplitude was linked to shorter lengths of stay and lower in-hospital mortality.

CARDIOVASCULAR DIGITAL HEALTH JOURNAL (2021)

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Review Physiology

Why Lungs Keep Time: Circadian Rhythms and Lung Immunity

Charles Nosal et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 82 (2020)

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Article Critical Care Medicine

Daily Changes in the Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin

Carlos Acuna-Fernandez et al.

SHOCK (2020)

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Review Biochemistry & Molecular Biology

Molecular Interactions Between Components of the Circadian Clock and the Immune System

Sophia Hergenhan et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Article Immunology

Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation

Jose M. Adrover et al.

NATURE IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

Peter S. Cunningham et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

Gareth B. Kitchen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Critical Care Medicine

Factors Disrupting Melatonin Secretion Rhythms During Critical Illness

Matthew B. Maas et al.

CRITICAL CARE MEDICINE (2020)

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Article Obstetrics & Gynecology

Circadian changes in the composition of human milk macronutrients depending on pregnancy duration: a cross-sectional study

Ieva Jura Paulaviciene et al.

INTERNATIONAL BREASTFEEDING JOURNAL (2020)

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Article Respiratory System

Circadian asthma airway responses are gated by REV-ERBα

Hannah J. Durrington et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Coupled network of the circadian clocks: a driving force of rhythmic physiology

Anna-Marie Finger et al.

FEBS LETTERS (2020)

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Article Biochemistry & Molecular Biology

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Jonas Schulte-Schrepping et al.

CELL (2020)

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Review Immunology

Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine

Benoit Pourcet et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Clinical Neurology

Circadian Disruption in Critical Illness

Aesha M. Jobanputra et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Critical Care Medicine

Circadian Gene Expression Rhythms During Critical Illness

Matthew B. Maas et al.

CRITICAL CARE MEDICINE (2020)

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Review Nutrition & Dietetics

Circadian Variation in Human Milk Composition, a Systematic Review

Merel F. Italianer et al.

NUTRIENTS (2020)

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Review Clinical Neurology

Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?

Marietou Daou et al.

FRONTIERS IN NEUROLOGY (2020)

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Review Oncology

An Optimal Time for Treatment-Predicting Circadian Time by Machine Learning and Mathematical Modelling

Janina Hesse et al.

CANCERS (2020)

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Review Cell Biology

Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease

Xiang Wang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Critical Care Medicine

Vital-sign circadian rhythms in patients prior to discharge from an ICU: a retrospective observational analysis of routinely recorded physiological data

Shaun Davidson et al.

CRITICAL CARE (2020)

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Article Critical Care Medicine

CIRCADIAN RHYTHM DISRUPTION AND SEPSIS IN SEVERE TRAUMA PATIENTS

Benjamin Coiffard et al.

SHOCK (2019)

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Article Critical Care Medicine

Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?

Richard K. Albert et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Nutrition & Dietetics

Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

Humaira Jamshed et al.

NUTRIENTS (2019)

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Article Multidisciplinary Sciences

Circadian control of lung inflammation in influenza infection

Shaon Sengupta et al.

NATURE COMMUNICATIONS (2019)

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Review Neurosciences

Rhythms of life: circadian disruption and brain disorders across the lifespan

Ryan W. Logan et al.

NATURE REVIEWS NEUROSCIENCE (2019)

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Article Immunology

BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes

A. Ehlers et al.

MUCOSAL IMMUNOLOGY (2018)

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Article Critical Care Medicine

Prognostic and Pathogenic Role of Angiopoietin-1 and-2 in Pneumonia

Birgitt Gutbier et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Article Cell Biology

Angiotensin II Suppresses Rev-erbα Expression in THP-1 Macrophages via the Ang II Type 1 Receptor/Liver X Receptor α Pathway

Shipeng Wang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Critical Care Medicine

The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium

Jennifer Gile et al.

CRITICAL CARE MEDICINE (2018)

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Article Medicine, Research & Experimental

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Marie Pariollaud et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Endocrinology & Metabolism

Circadian regulation of glucose, lipid, and energy metabolism in humans

Eleonora Poggiogalle et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

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Article Multidisciplinary Sciences

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Jakob Wefers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Cell Biology

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis

Wenjun Deng et al.

CELL REPORTS (2018)

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Review Endocrinology & Metabolism

Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells

Ana C. Liberman et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Review Cell Biology

The effect of fasting or calorie restriction on autophagy induction: A review of the literature

Mohammad Bagherniya et al.

AGEING RESEARCH REVIEWS (2018)

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Article Medicine, Research & Experimental

High-accuracy determination of internal circadian time from a single blood sample

Nicole Wittenbrink et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Review Endocrinology & Metabolism

Melatonin and inflammation-Story of a double-edged blade

Ruediger Hardeland

JOURNAL OF PINEAL RESEARCH (2018)

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Article Multidisciplinary Sciences

Universal method for robust detection of circadian state from gene expression

Rosemary Braun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Biochemistry & Molecular Biology

Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis

Ching-Chou Tsai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Immunology

Clocking in to immunity

Christoph Scheiermann et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Review Toxicology

WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit-risk evaluation of breastfeeding

Martin van den Berg et al.

ARCHIVES OF TOXICOLOGY (2017)

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Review Endocrinology & Metabolism

The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

Henrik Oster et al.

ENDOCRINE REVIEWS (2017)

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Review Genetics & Heredity

Transcriptional architecture of the mammalian circadian clock

Joseph S. Takahashi

NATURE REVIEWS GENETICS (2017)

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Article Medicine, General & Internal

Effects of dexmedetomidine on sleep quality of patients after surgery without mechanical ventilation in ICU

Weina Lu et al.

MEDICINE (2017)

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Article Multidisciplinary Sciences

Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass

Alicia Mayeuf-Louchart et al.

SCIENTIFIC REPORTS (2017)

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Article Neurosciences

Effects of Dim Light at Night on Food Intake and Body Mass in Developing Mice

Yasmine M. Cisse et al.

FRONTIERS IN NEUROSCIENCE (2017)

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Article Multidisciplinary Sciences

Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice

Benjamin L. Smarr et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

CLOCK modulates survival and acute lung injury in mice with polymicrobial sepsis

Chao-Yung Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Review Critical Care Medicine

Circadian Rhythm Disruption in the Critically Ill: An Opportunity for Improving Outcomes

Mark A. Oldham et al.

CRITICAL CARE MEDICINE (2016)

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Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Multidisciplinary Sciences

Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

Ariadna Amador et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Cell autonomous regulation of herpes and influenza virus infection by the circadian clock

Rachel S. Edgar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Review Multidisciplinary Sciences

Circadian time signatures of fitness and disease

Joseph Bass et al.

SCIENCE (2016)

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Article Obstetrics & Gynecology

Circadian Macronutrients Variations over the First 7 Weeks of Human Milk Feeding of Preterm Infants

Hadar Moran-Lev et al.

BREASTFEEDING MEDICINE (2015)

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Article Developmental Biology

Effects of Melatonin on Prenatal Dexamethasone-Induced Epigenetic Alterations in Hippocampal Morphology and Reelin and Glutamic Acid Decarboxylase 67 Levels

Chun-Chung Lui et al.

DEVELOPMENTAL NEUROSCIENCE (2015)

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Article Clinical Neurology

The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea

Matthew P. Butler et al.

SLEEP (2015)

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Article Multidisciplinary Sciences

Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD

Isaac K. Sundar et al.

Scientific Reports (2015)

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Article Psychiatry

Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine

S. Spulber et al.

TRANSLATIONAL PSYCHIATRY (2015)

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Article Critical Care Medicine

Timing and causes of death in septic shock

Fabrice Daviaud et al.

ANNALS OF INTENSIVE CARE (2015)

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Article Gastroenterology & Hepatology

Influence of Proton-Pump Inhibitors on the Luminal Microbiota in the Gastrointestinal Tract

Ayumi Tsuda et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2015)

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Article Clinical Neurology

The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea

Matthew P. Butler et al.

SLEEP (2015)

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Article Biology

Clock-controlled StAR's expression and corticosterone production contribute to the endotoxemia immune response

Jiesi Wang et al.

CHRONOBIOLOGY INTERNATIONAL (2015)

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Article Respiratory System

Therapeutic strategies in pneumonia: going beyond antibiotics

Holger Mueller-Redetzky et al.

EUROPEAN RESPIRATORY REVIEW (2015)

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Review Anesthesiology

Mechanical Ventilation-associated Lung Fibrosis in Acute Respiratory Distress Syndrome A Significant Contributor to Poor Outcome

Nuria E. Cabrera-Benitez et al.

ANESTHESIOLOGY (2014)

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Article Medicine, General & Internal

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

Annemarieke de Jonghe et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2014)

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Review Cell Biology

Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives

Holger C. Mueller-Redetzky et al.

CELL AND TISSUE RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway

Jae-Woong Hwang et al.

FASEB JOURNAL (2014)

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Article Biochemistry & Molecular Biology

Maternal citrulline supplementation prevents prenatal dexamethasone-induced programmed hypertension

Y. L. Tain et al.

FREE RADICAL RESEARCH (2014)

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Article Cell Biology

CLOCK: BMAL1 is a pioneer-like transcription factor

Jerome S. Menet et al.

GENES & DEVELOPMENT (2014)

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Article Immunology

A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury

Huan Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

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Article Peripheral Vascular Disease

Melatonin attenuates prenatal dexamethasone-induced blood pressure increase in a rat model

You-Lin Tain et al.

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION (2014)

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Article Biochemistry & Molecular Biology

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

Julie Gibbs et al.

NATURE MEDICINE (2014)

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Review Mathematical & Computational Biology

Cosinor-based rhythmometry

Germaine Cornelissen

THEORETICAL BIOLOGY AND MEDICAL MODELLING (2014)

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Article Multidisciplinary Sciences

Circadian rhythm reprogramming during lung inflammation

Jeffrey A. Haspel et al.

NATURE COMMUNICATIONS (2014)

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Article Critical Care Medicine

Critical Illness Myopathy and GLUT4 Significance of Insulin and Muscle Contraction

Steffen Weber-Carstens et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

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Article Critical Care Medicine

Altered Circadian Rhythmicity in Patients in the ICU

Joost A. C. Gazendam et al.

CHEST (2013)

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Article Nursing

Variation in Fat, Lactose, and Protein Composition in Breast Milk over 24 Hours: Associations with Infant Feeding Patterns

Sadaf Khan et al.

JOURNAL OF HUMAN LACTATION (2013)

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Article Biochemistry & Molecular Biology

Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

Estelle Woldt et al.

NATURE MEDICINE (2013)

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Review Medicine, General & Internal

Ventilator-Induced Lung Injury

Arthur S. Slutsky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Multidisciplinary Sciences

Impact of Chronodisruption during Primate Pregnancy on the Maternal and Newborn Temperature Rhythms

Maria Seron-Ferre et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Characterisation of the Maternal Response to Chronic Phase Shifts during Gestation in the Rat: Implications for Fetal Metabolic Programming

Tamara J. Varcoe et al.

PLOS ONE (2013)

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Article Endocrinology & Metabolism

Designing artificial environments for preterm infants based on circadian studies on pregnant uterus

Shimpei Watanabe

Frontiers in Endocrinology (2013)

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Article Critical Care Medicine

Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition

Nuria E. Cabrera-Benitez et al.

CRITICAL CARE MEDICINE (2012)

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Article Multidisciplinary Sciences

Peroxiredoxins are conserved markers of circadian rhythms

Rachel S. Edgar et al.

NATURE (2012)

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Article Multidisciplinary Sciences

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Julie E. Gibbs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Endocrinology & Metabolism

Circadian Variation in Placental and Hepatic Clock Genes in Rat Pregnancy

Michaela D. Wharfe et al.

ENDOCRINOLOGY (2011)

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Article Multidisciplinary Sciences

Circadian clocks in human red blood cells

John S. O'Neill et al.

NATURE (2011)

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Article Biochemistry & Molecular Biology

Coupling governs entrainment range of circadian clocks

Ute Abraham et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

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Article Anesthesiology

Assessment of role of perioperative melatonin in prevention and treatment of postoperative delirium after hip arthroplasty under spinal anesthesia in the elderly

Sherif S. Sultan

SAUDI JOURNAL OF ANAESTHESIA (2010)

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Article Biology

DIURNAL VARIATION IN ENDOTOXIN-INDUCED MORTALITY IN MICE: CORRELATION WITH PROINFLAMMATORY FACTORS

Luciano Marpegan et al.

CHRONOBIOLOGY INTERNATIONAL (2009)

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Article Multidisciplinary Sciences

A circadian clock in macrophages controls inflammatory immune responses

Maren Keller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Physiology

Effects of melatonin in an experimental model of ventilator-induced lung injury

Paula R. Pedreira et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

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Review Behavioral Sciences

How to assess circadian rhythm in humans: A review of literature

Wytske A. Hofstra et al.

EPILEPSY & BEHAVIOR (2008)

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Article Immunology

Chronic inflammation affects the photic response of the suprachiasmatic nucleus

Maria Palomba et al.

JOURNAL OF NEUROIMMUNOLOGY (2008)

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Article Medicine, General & Internal

Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

Frank Buttgereit et al.

LANCET (2008)

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Article Critical Care Medicine

The absence of circadian cues during recovery from sepsis modifies pituitary-adrenocortical function and impairs survival

Drew E. Carlson et al.

SHOCK (2008)

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Article Critical Care Medicine

Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial

Richard S. Bourne et al.

CRITICAL CARE (2008)

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Review Clinical Neurology

Circadian rhythm sleep disorders: Part 1, basic principles, shift work and jet lag disorders

Robert L. Sack et al.

SLEEP (2007)

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Review Clinical Neurology

Circadian rhythm sleep disorders: Part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm

Robert L. Sack et al.

SLEEP (2007)

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Article Multidisciplinary Sciences

TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription

Gionata Cavadini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Neurosciences

Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin-releasing hormone

Ying-Hui Wu et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2006)

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Article Multidisciplinary Sciences

Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain

T Ubuka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Multidisciplinary Sciences

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

SH Yoo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Pediatrics

Rest-activity patterns of premature infants are regulated by cycled lighting

SA Rivkees et al.

PEDIATRICS (2004)

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Article Medicine, General & Internal

Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity

TF Yeh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

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Article Anesthesiology

Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients

K Olofsson et al.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2004)

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Article Biology

Effects of diazepam and its metabolites on nocturnal melatonin secretion in the rat pineal and Harderian glands. A comparative in vivo and in vitro study

Y Djeridane et al.

CHRONOBIOLOGY INTERNATIONAL (2003)

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Article Endocrinology & Metabolism

Melatonin receptors in human fetal brain:: 2-[125I] iodomelatonin binding and MT1 gene expression

L Thomas et al.

JOURNAL OF PINEAL RESEARCH (2002)

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Article Multidisciplinary Sciences

Extensive and divergent circadian gene expression in liver and heart

KF Storch et al.

NATURE (2002)

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Article Pediatrics

Preterm infants born at less than 31 weeks' gestation have improved growth in cycled light compared with continuous near darkness

DH Brandon et al.

JOURNAL OF PEDIATRICS (2002)

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Article Critical Care Medicine

Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis

G Mundigler et al.

CRITICAL CARE MEDICINE (2002)

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Article Biology

Modeling the circadian variability of ambulatorily monitored blood pressure by multiple-component analysis

RC Hermida et al.

CHRONOBIOLOGY INTERNATIONAL (2002)

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Article Medicine, General & Internal

Intensive insulin therapy in critically ill patients.

G Van den Berghe et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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Article Biochemistry & Molecular Biology

Mop3 is an essential component of the master circadian pacemaker in mammals

MK Bunger et al.

CELL (2000)

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Article Multidisciplinary Sciences

Resetting of circadian time peripheral tissues by glucocorticoid signaling

A Balsalobre et al.

SCIENCE (2000)

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Review Biology

Alterations with aging of the endocrine and neuroendocrine circadian system in humans

Y Touitou et al.

CHRONOBIOLOGY INTERNATIONAL (2000)

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Article Critical Care Medicine

Endogenous circadian rhythm of pulmonary function in healthy humans

CM Spengler et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

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Circadian rhythm disruption in critically ill patients

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