Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription

Article Cell Biology

The Nuclear Pore Complex as a Transcription Regulator

Michael Chas Summer et al.

Summary: The nuclear pore complex is a channel in the nuclear envelope that controls mRNA export, protein transport, and influences genome organization and function.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2022)

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Article Oncology

Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death

Stephen Sakuma et al.

Summary: Reducing nuclear pore complex (NPC) numbers in cancer cells induces cell death, prevents tumor growth, and results in tumor regression, while normal cells undergo a reversible cell-cycle arrest in response to inhibition of NPC assembly. These findings highlight the potential of targeting NPC formation as a novel pathway in cancer treatment.

CANCER DISCOVERY (2021)

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Article Cell Biology

Cargo transport through the nuclear pore complex at a glance

Giulia Paci et al.

Summary: This article provides an overview of the bidirectional transport of macromolecules across the nuclear envelope, focusing on the role of the nuclear pore complex in regulating nucleocytoplasmic transport. It also discusses how different cargo properties, such as size and number of bound nuclear transport receptors, can affect nuclear transport.

JOURNAL OF CELL SCIENCE (2021)

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Review Genetics & Heredity

Heart Enhancers: Development and Disease Control at a Distance

Xuefei Yuan et al.

Summary: Enhancers, crucial in controlling spatiotemporal gene expression profiles, are regulated by lineage-determining transcription factors and signaling effectors. Recent advancements in functional genomic technologies have led to unprecedented genome-wide annotation of heart enhancers and their target genes. Studying heart enhancers in various metazoan species has significantly contributed to our understanding of cardiac development and disease.

FRONTIERS IN GENETICS (2021)

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Article Biochemistry & Molecular Biology

Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis

Ophelie Lautier et al.

Summary: The research reveals that the formation of the nuclear pore complex involves co-translational events in the cytoplasm and nucleus. Different NPC subunits establish binary interactions during translation. Localized translation ensures the proper delivery of proteins to the pore and the nucleus.

MOLECULAR CELL (2021)

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Review Cell Biology

Epigenetics and Heart Development

Rajani M. George et al.

Summary: Recent research has focused on the epigenetic control of gene expression during cardiac development and disease, identifying chromatin structures that regulate access of transcription factors to genes and its implications in congenital heart disease. The factors controlling this process and their role in changing gene expression during development or disease remain unclear.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Therapies Targeted at Non-Coding RNAs in Prevention and Limitation of Myocardial Infarction and Subsequent Cardiac Remodeling-Current Experience and Perspectives

Michal Kowara et al.

Summary: Myocardial infarction is a major cause of mortality worldwide, mainly caused by the progression, destabilization, and rupture of atherosclerotic plaques. Targeted therapies aimed at limiting plaque progression, reducing cardiac damage, and preventing cardiac remodeling are urgently needed for treating this disease. Targeting and regulating non-coding RNAs like microRNA, circular RNA, and long non-coding RNA show promise as potential therapeutic options for the future medicine.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology