期刊
ACTA OTO-LARYNGOLOGICA
卷 143, 期 6, 页码 536-542出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016489.2023.2220371
关键词
Parotid carcinoma; submandibular carcinoma; adenoid cystic carcinoma; grade; recurrence; outcome
This study aimed to clarify the clinical characteristics of adenoid cystic carcinoma (AdCC) of salivary glands and examine factors associated with recurrence and prognosis by histopathological grade classification. The results showed that patients in grade III had significantly higher age, proportions of patients with lymph node metastasis (cN+, pN+), and perineural invasion. Lower-grade groups showed higher rates of correct histopathological type on fine-needle aspiration cytology (FNAC). Five-year disease-specific survival and disease-free survival rates were significantly lower in grade III. High-stage and perineural invasion were associated with more distant metastases.
BackgroundPrognostic factors and survival rate are difficult to determine for adenoid cystic carcinoma(AdCC) of salivary glands.Aims/objectivesTo clarify the clinical characteristics of AdCC and examine factors associated with recurrence and prognosis by histopathological grade classification.Materials and methodsTwenty-five patients with AdCC of the parotid gland and 10 patients with AdCC of the submandibular gland were included. We classified AdCC histopathologically by the proportion of solid components. Clinical features, fine-needle aspiration cytology (FNAC), and patient outcomes were examined according to grade. Factors associated with local recurrence and distant metastases were examined.ResultsAge was significantly higher in the grade III group than in the grade I group. The grade III group had significantly higher proportions of patients with cN+, pN+, and perineural invasion. In FNAC, lower-grade groups showed higher rates of correct histopathological type. Five-year disease-specific survival and disease-free survival rates were significantly lower in the grade III than in the grade I. Distant metastases were more common among patients with high-stage and perineural invasion.ConclusionsFive-year survival is significantly worse in patients with grade III.
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