期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 10, 页码 3270-3273出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b12095
关键词
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资金
- Swiss National Science Foundation [200020_152850/1]
- European Research Council [257096]
- Swiss National Science Foundation (SNF) [200020_152850] Funding Source: Swiss National Science Foundation (SNF)
[Fe]-Hydrogenase catalyzes the hydrogenation of a biological substrate via the heterolytic splitting of molecular hydrogen. While many synthetic models of [Fe]-hydrogenase have been prepared, none yet are capable of activating H-2 on their own. Here, we report the first Fe-based functional mimic of the active site of [Fe]-hydrogenase, which was developed based on a mechanistic understanding. The activity of this iron model complex is enabled by its unique ligand environment, consisting of biomimetic pyridinylacyl and carbonyl ligands, as well as a bioinspired diphosphine ligand with a pendant amine moiety. The model complex activates H-2 and mediates hydrogenation of an aldehyde.
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