4.8 Article

Intracellular Hyperbranched Polymerization for Circumventing Cancer Drug Resistance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Artificial intelligence aids in development of nanomedicines for cancer management

Ping Tan et al.

Summary: In the past decade, nanomedicine has seen unprecedented development in disease diagnosis and treatment. Several nanomedicines have been approved for clinical use, demonstrating the potential value of transitioning nanotechnology-modified medicines from the lab to the bedside. The application of artificial intelligence (AI) in the development of nanotechnology-based products has the potential to transform healthcare by enabling the acquisition and analysis of large datasets and tailoring precision nanomedicines for cancer management.

SEMINARS IN CANCER BIOLOGY (2023)

Review Engineering, Biomedical

Drug Self-Delivery Systems: Molecule Design, Construction Strategy, and Biological Application

Chengfei Liu et al.

Summary: Drug self-delivery systems (DSDSs) offer new ways to create novel drug delivery systems (DDSs) by utilizing therapeutic reagents as active delivery agents. This review focuses on the recent advances and future trends in covalent and noncovalent bond-based DSDSs, discussing various chemical and architectural designs, fabrication strategies, and responsive and functional features. The potential applications of molecular designs in DSDSs are also presented, highlighting the promising potential of DSDSs in biological applications and their relationship with therapeutic effects.

ADVANCED HEALTHCARE MATERIALS (2023)

Article Chemistry, Multidisciplinary

In Situ Sprayed Biotherapeutic Gel Containing Stable Microbial Communities for Efficient Anti-Infection Treatment

Jian-Hua Yan et al.

Summary: This study presents a biotherapeutic gel system that is constructed using stable microbial communities to control multidrug-resistant bacterial infections and promote wound healing. The gel demonstrates broad-spectrum antimicrobial activity and strong antibacterial effects in various pathogenic bacteria-derived infection models. Compared to a commercial antibacterial gel, the biotherapeutic gel outperforms in terms of pathogen removal and infected wound healing.

ADVANCED SCIENCE (2023)

Article Chemistry, Multidisciplinary

Tumor-Specific NIR-Activatable Nanoreactor for Self-Enhanced Multimodal Imaging and Cancer Phototherapy

Lili Feng et al.

Summary: We have developed a tumor microenvironment responsive and near-infrared (NIR)-activatable theranostic nanoreactor for imaging-guided anticancer therapy. The nanoreactor is comprised of hollow mesoporous black SnO2-x nanoparticles encapsulated with poly(vinylpyrrolidine), glucose oxidase (GOx), and 2,2 '-azinobis(3-ethylbenzothiazoline-6-sul-fonic acid) (ABTS). The constructed nanoreactor can be specifically activated through endogenous H2O2 by an NIR-mediated bursting-like process to enhance its imaging and therapeutic functions.

ACS NANO (2023)

Article Chemistry, Multidisciplinary

Attenuating Metabolic Competition of Tumor Cells for Favoring the Nutritional Demand of Immune Cells by a Branched Polymeric Drug Delivery System

Yinggang Li et al.

Summary: Tumor cells dominate the nutritional competition in the tumor microenvironment, leading to acidosis and nutrient deprivation, which impairs immune cells and reduces the effectiveness of anti-tumor therapy. A branched polymeric conjugate was developed to interfere with tumor cell metabolism and create a favorable environment for immune cells. Combined with an immune checkpoint inhibitor, it enhanced the anti-tumor effect, providing a promising approach for chemo-immunotherapy against cancers.

ADVANCED MATERIALS (2023)

Article Chemistry, Multidisciplinary

Albumin-Based Therapeutics Capable of Glutathione Consumption and Hydrogen Peroxide Generation for Synergetic Chemodynamic and Chemotherapy of Cancer

Guangbao Yang et al.

Summary: A nanoscale therapeutic system was fabricated by coassembly of human serum albumin and glucose oxidase, which effectively eliminates tumor cells through the combination of catalysis and chemotherapeutic prodrug conversion, demonstrating high therapeutic efficacy.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Enzyme-Mediated Intracellular Polymerization of AIEgens for Light-Up Tumor Localization and Theranostics

Guobin Qi et al.

Summary: This study introduces an enzyme-mediated polymerization strategy for AIEgen, promoting its accumulation and retention in tumors for prolonged imaging and enhanced tumor growth inhibition.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Combining Hydroxyl-Yne and Thiol-Ene Click Reactions to Facilely Access Sequence-Defined Macromolecules for High-Density Data Storage

Bo Song et al.

Summary: Scientists have developed a new method to synthesize sequence-defined macromolecules with high data storage density, offering new possibilities for applications in information encoding and encryption.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Review Polymer Science

Living cell-me diate d in-situ polymerization for biome dical applications

Jingjing Liu et al.

Summary: This paper reviews the applications of synthetic polymers in biomedicine and discusses the method of cell-mediated in-situ polymerization. It also examines the biological effects of these polymers on living cells and animals.

PROGRESS IN POLYMER SCIENCE (2022)

Article Chemistry, Multidisciplinary

Cation-π Interaction-Mediated Tumour Drug Delivery for Deep Intratumoral Penetration and Treatment

Chengfei Liu et al.

Summary: This study utilizes cation-pi interactions to construct a novel tumor drug delivery system that combines the advantages of both passive and active transport mechanisms. The system is capable of smartly releasing drugs in acidic tumor microenvironment and achieving deep intratumoral penetration through both passive diffusion and active transport.

ADVANCED FUNCTIONAL MATERIALS (2022)

Review Chemistry, Multidisciplinary

Polymer Chemistry in Living Cells

Zhixuan Zhou et al.

Summary: The polymerization of biomolecules plays a crucial role in connecting molecular signals with various cellular events. It leads to the creation of functional capabilities and phase separation phenomena, and contributes to the formation of hierarchical structures in cell biology. Despite significant progress in synthetic polymer chemistry, studying polymer behavior in complex multicomponent systems remains challenging. Conducting polymer chemistry within cells offers a new perspective for understanding the nanoscale world of living cells and has the potential to revolutionize macromolecular therapeutics and biology.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

Article Chemistry, Multidisciplinary

One-Pot Structure-Controlled Synthesis of Hyperbranched Polymers by a Latent Inimer Strategy Based on Diels-Alder Chemistry

Neng Yang et al.

Summary: An efficient one-pot strategy for the structure-controlled synthesis of hyperbranched polymers (HBPs) has been developed. By using a latent inimer and regulating the temperature or stereochemistry, the release of maleimide (MI) and subsequent copolymerization can be controlled, leading to the synthesis of HBPs with various degrees of branching.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Chemistry, Multidisciplinary

Light-Triggered Self-Assembly of Peptide Nanoparticles into Nanofibers in Living Cells through Molecular Conformation Changes and H-Bond Interactions

Si Sun et al.

Summary: Controlled self-assembly is of great interest in biological and nanotechnological applications. We have demonstrated a light-triggered platform that allows precise control of self-assembly from nanoparticles into nanofibers in living cells. The process is biocompatible, fast, and can be applied for regulating molecular assembly in living cells.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Polymer Materials Synthesized through Cell-Mediated Polymerization Strategies for Regulation of Biological Functions

Qi Shen et al.

Summary: This Account summarizes recent developments in the design of cell-mediated in situ polymerization methods and demonstrates their potential applications in tumor cell labeling and treatment, microbial photosynthetic efficiency regulation, and hydrogel generation. By designing molecular structures, in situ synthesized polymers in the cellular microenvironment can regulate biological functions.

ACCOUNTS OF MATERIALS RESEARCH (2022)

Article Chemistry, Multidisciplinary

Controlled Intracellular Polymerization for Cancer Treatment

Yichuan Zhang et al.

Summary: In this study, a photoactivatable prodrug system based on PET-RAFT polymerization was developed for the synthesis of structure-predictable polymers in living cells. The generated polymers showed inhibitory effects on cancer cell growth and migration.

JACS AU (2022)

Review Pharmacology & Pharmacy

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Yunjiang Jiang et al.

Summary: AMPs and SMAMPs have attracted significant enthusiasm in the past thirty years due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. Despite challenges inherent to current design strategies slowing down the clinical translational development of AMPs and SMAMPs, these challenges have triggered efforts to redesign and repurpose AMPs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Chemistry, Multidisciplinary

Hyperbranched Microwire Networks of Organic Cocrystals with Optical Waveguiding and Light-Harvesting Abilities

Zuofang Feng et al.

Summary: This study discusses the synthesis of hyperbranched organic microwire networks through a simple solution co-assembly route, resulting in highly aligned and well-connected MW networks with superior optical waveguiding ability. BA acts as an intermediate product to facilitate the regeneration of binary cocrystals, leading to the formation of complex MW arrays during the epitaxial growth process.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

In Situ Synthesis of Photoactive Polymers on a Living Cell Surface via Bio-Palladium Catalysis for Modulating Biological Functions

Ruilian Qi et al.

Summary: Cell surface engineering with functional polymers using a bio-metal catalyzed polymerization method is effective in modulating cell activity. This strategy allows for in situ synthesis of conjugated polymers on living cell surfaces, which not only aids in imaging microbes and tracing polymerization processes, but also enhances antibacterial activity and ATP synthesis in algae.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Chemistry, Multidisciplinary

Dendritic Hydrogels Induce Immune Modulation in Human Keratinocytes and Effectively Eradicate Bacterial Pathogens

Yanmiao Fan et al.

Summary: Novel cationic hydrogels based on amino-functional hyperbranched dendritic-linear-dendritic copolymers exhibit excellent antimicrobial activity against a wide range of clinical bacteria, including drug-resistant strains. The hydrogels can induce the expression of antimicrobial peptides in human keratinocytes, reducing inflammation and promoting bacterial killing.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Biochemistry & Molecular Biology

Platinum-Containing Supramolecular Drug Self-Delivery Nanomicelles for Efficient Synergistic Combination Chemotherapy

Chengfei Liu et al.

Summary: The study utilized platinum-containing supramolecular drug self-delivery nanomicelles for drug monitoring through computed tomography imaging and real-time treatment, achieving efficient synergistic combination chemotherapy with strong tumor inhibition effects and good safety. Such a supramolecular drug self-delivery strategy with monitored functions opens up new potential opportunities for application in synergistic combination chemotherapy.

BIOMACROMOLECULES (2021)

Article Chemistry, Multidisciplinary

Oxidative Polymerization in Living Cells

Yiheng Dai et al.

Summary: This study demonstrates a novel oxidative polymerization reaction in cells triggered by intracellular ROS, selectively inducing apoptosis in cancer cells. The polymerization products disrupt intracellular antioxidant systems, leading to increased oxidative stress, further promoting oxidative polymerization and activating apoptosis pathways related to ROS. The anticancer efficacy and biosafety of this strategy are proven in vitro and in vivo, suggesting a new possibility for chemists to manipulate cellular behavior through artificial chemical reactions.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Materials Science, Multidisciplinary

Intracellular Radical Polymerization of Paclitaxel-Bearing Acrylamide for Self-Inflicted Apoptosis of Cancer Cells

Qi Shen et al.

Summary: This study presents a method for intracellular radical polymerizations promoted by the redox response of the tumor microenvironment, achieving a high conversion rate of 97% within 2 hours for the synthesis of functional macromolecules inside living cells. The critical factors of intracellular polymerization were found to be related to the redox status of GSH/GSSG, and tumor cells were able to induce their apoptosis using in situ synthesized polymers.

ACS MATERIALS LETTERS (2021)

Article Chemistry, Multidisciplinary

Iron-Catalysed Radical Polymerisation by Living Bacteria

Mechelle R. Bennett et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Diselenide-Pemetrexed Assemblies for Combined Cancer Immuno-, Radio-, and Chemotherapies

Tianyu Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

An Activatable Polymeric Reporter for Near-Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer

Qing Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

Shasha He et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Controlled Supramolecular Assembly Inside Living Cells by Sequential Multistaged Chemical Reactions

Michaela Pieszka et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Reduction Triggered In Situ Polymerization in Living Mice

Lina Cui et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Bioorthogonal Swarming: In Situ Generation of Dendrimers

Yichuan Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Radical polymerization inside living cells

Jin Geng et al.

NATURE CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy

Li-Sen Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Chemistry, Multidisciplinary

Designed transition metal catalysts for intracellular organic synthesis

Yugang Bai et al.

CHEMICAL SOCIETY REVIEWS (2018)

Review Chemistry, Multidisciplinary

Dendrimers in combination with natural products and analogues as anti-cancer agents

Serge Mignani et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Chemistry, Multidisciplinary

Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery

Lu Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Engineering, Biomedical

A non-cytotoxic dendrimer with innate and potent anticancer and anti-metastatic activities

Shiqun Shao et al.

NATURE BIOMEDICAL ENGINEERING (2017)

Review Engineering, Biomedical

Drug self-delivery systems for cancer therapy

Si-Yong Qin et al.

BIOMATERIALS (2017)

Review Chemistry, Multidisciplinary

Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization

Qihang Sun et al.

ADVANCED MATERIALS (2017)

Article Nanoscience & Nanotechnology

Selenium-Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity

Tianyu Li et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Article Nanoscience & Nanotechnology

Ultrasensitive ROS-Responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids

Lu Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Article Chemistry, Multidisciplinary

Ultra-sensitive ROS-responsive tellurium-containing polymers

Wei Cao et al.

CHEMICAL COMMUNICATIONS (2015)

Article Polymer Science

Reactive oxygen species (ROS)-responsive tellurium-containing hyperbranched polymer

Ruochen Fang et al.

POLYMER CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Combination of Small Molecule Prodrug and Nanodrug Delivery: Amphiphilic Drug-Drug Conjugate for Cancer Therapy

Ping Huang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Review Polymer Science

Dendrimer as nanocarrier for drug delivery

Prashant Kesharwani et al.

PROGRESS IN POLYMER SCIENCE (2014)

Review Multidisciplinary Sciences

Oxidants, oxidative stress and the biology of ageing

T Finkel et al.

NATURE (2000)