相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Discovery of novel dual acetylcholinesterase and butyrylcholinesterase inhibitors using machine learning and structure-based drug design
Manish Kumar Tripathi et al.
JOURNAL OF MOLECULAR STRUCTURE (2023)
Exploration of Neuroprotective Properties of a Naturally Inspired Multifunctional Molecule (F24) against Oxidative Stress and Amyloid β Induced Neurotoxicity in Alzheimer's Disease Models
Yash Pal Singh et al.
ACS CHEMICAL NEUROSCIENCE (2022)
The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer's disease
Akash Verma et al.
BIOORGANIC CHEMISTRY (2022)
Inhibition of pan-Aurora kinase attenuates evoked and ongoing pain in nerve injured rats via regulating KIF17-NR2B mediated signaling
Ankit Uniyal et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
Modulation of KIF17/NR2B crosstalk by tozasertib attenuates inflammatory pain in rats
Ankit Uniyal et al.
INFLAMMOPHARMACOLOGY (2022)
Discovery of 1,3,4-oxadiazole derivatives containing a bisamide moiety as a novel class of potential cardioprotective agents
Fei-Fei Yang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Aducanumab: The first targeted Alzheimer's therapy
Pan Yang et al.
DRUG DISCOVERIES AND THERAPEUTICS (2021)
Neuroprotective Effect of Epalrestat on Hydrogen Peroxide-Induced Neurodegeneration in SH-SY5Y Cellular Model
Sivakumar Lingappa et al.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2021)
DFT Calculations and Molecular Docking Studies on a Chromene Derivative
Najet Aouled Dlala et al.
JOURNAL OF CHEMISTRY (2021)
Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxa-diazole as multitargeted hybrids for the treatment of Alzheimer's disease
Priyanka Kumari Choubey et al.
BIOORGANIC CHEMISTRY (2021)
Epigallocatechin-3-gallate improves chronic alcohol-induced cognitive dysfunction in rats by interfering with neuro-inflammatory, cell death and oxido-nitrosative cascade
Ankit Uniyal et al.
METABOLIC BRAIN DISEASE (2021)
Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson's disease
Akanksha Mishra et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)
Design, synthesis, and biological evaluation of ferulic acid based 1,3,4-oxadiazole hybrids as multifunctional therapeutics for the treatment of Alzheimer's disease
Avanish Tripathi et al.
BIOORGANIC CHEMISTRY (2020)
Computational exploration and experimental validation to identify a dual inhibitor of cholinesterase and amyloid-beta for the treatment of Alzheimer's disease
Manish Kumar Tripathi et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2020)
Novel Benzylated (Pyrrolidin-2-one)/(Imidazolidin-2-one) Derivatives as Potential Anti-Alzheimer's Agents: Synthesis and Pharmacological Investigations
Mohan Gupta et al.
ACS CHEMICAL NEUROSCIENCE (2020)
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents
Yixiang Xu et al.
ACS CHEMICAL NEUROSCIENCE (2019)
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory
Pavan Srivastava et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles
Wiliam Caneschi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation
Rudy J. Castellani et al.
LABORATORY INVESTIGATION (2019)
Design and development of novel N-(pyrimidin-2-yl)-1,3,4-oxadiazole hybrids to treat cognitive dysfunctions
Prabhash Nath Tripathi et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory
Prabhash Nath Tripathi et al.
BIOORGANIC CHEMISTRY (2019)
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease
Piyoosh Sharma et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease
Piyoosh Sharma et al.
ACS CHEMICAL NEUROSCIENCE (2019)
Development of pyrazole and spiropyrazoline analogs as multifunctional agents for treatment of Alzheimer's disease
Gopichand Gutti et al.
BIOORGANIC CHEMISTRY (2019)
Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species
Xu-Qiao Chen et al.
FRONTIERS IN NEUROSCIENCE (2019)
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
Piyoosh Sharma et al.
PROGRESS IN NEUROBIOLOGY (2019)
Alzheimer's disease hypothesis and related therapies
Xiaoguang Du et al.
TRANSLATIONAL NEURODEGENERATION (2018)
Synthesis, evaluation and docking studies of some 4-thiazolone derivatives as effective lipoxygenase inhibitors
Sushant Kumar Shrivastava et al.
CHEMICAL PAPERS (2018)
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a Bio-Oxidizable Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation
Ludovic Peauger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
A systemic view of Alzheimer disease - insights from amyloid-β metabolism beyond the brain
Jun Wang et al.
NATURE REVIEWS NEUROLOGY (2017)
Novel Triazole-Piperazine Hybrid Molecules Induce Apoptosis via Activation of the Mitochondrial Pathway and Exhibit Antitumor Efficacy in Osteosarcoma Xenograft Nude Mice Model
Chandra Bhushan Mishra et al.
ACS CHEMICAL BIOLOGY (2017)
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography
Xiaoming Zha et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities
Heba S. Abd-Ellah et al.
BIOORGANIC CHEMISTRY (2016)
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis
Galina Karabanovich et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
Hye Yun Kim et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)
Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity
Philipp Spitzer et al.
SCIENTIFIC REPORTS (2016)
Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability
J. I. Forster et al.
JOURNAL OF BIOMOLECULAR SCREENING (2016)
Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms
Nial P. Harte et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer's Disease: The Design of Donecopride
Christophe Rochais et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis
George S. Bloom
JAMA NEUROLOGY (2014)
Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity
Daniel Silva et al.
ACS CHEMICAL NEUROSCIENCE (2013)
Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders
Werner J. Geldenhuys et al.
EXPERT OPINION ON DRUG DISCOVERY (2013)
Potential of a γ-Glutamyl-Transpeptidase-Stable Glutathione Analogue against Amyloid-β Toxicity
Swati S. More et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Dye-Binding Assays for Evaluation of the Effects of Small Molecule Inhibitors on Amyloid (Aβ) Self-Assembly
Laramie P. Jameson et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Inhibitory effect of curcumin on the Al(III)-induced Aβ42 aggregation and neurotoxicity in vitro
Teng Jiang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)
Nitric oxide synthases: regulation and function
Ulrich Foerstermann et al.
EUROPEAN HEART JOURNAL (2012)
Multi-Target-Directed Ligands in Alzheimer's Disease Treatment
M. Bajda et al.
CURRENT MEDICINAL CHEMISTRY (2011)
Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations
Tingjun Hou et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Alzheimer's disease: Effects of beta-amyloid on mitochondria
Laurent Tillement et al.
MITOCHONDRION (2011)
Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion-Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model
Oksana Tsinman et al.
PHARMACEUTICAL RESEARCH (2011)
The role of CREB signaling in Alzheimer's disease and other cognitive disorders
Carlos A. Saura et al.
REVIEWS IN THE NEUROSCIENCES (2011)
Alzheimer's Disease: A General Introduction and Pathomechanism
Verena H. Finder
JOURNAL OF ALZHEIMERS DISEASE (2010)
The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
Inge Klinkenberg et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2010)
Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution
Harry Levine
PROTEIN SCIENCE (2010)
Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent Melanin-Concentrating Hormone Receptor 1 (MCH-R1) antagonists
Susanne Berglund et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Inhibition of β-amyloid peptide aggregation and neurotoxicity by α-D-mannosylglycerate, a natural extremolyte
Jungki Ryu et al.
PEPTIDES (2008)
Multi-target-directed drug design strategy: From a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease
Maria Laura Bolognesi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
ASTRA -: a program package for accurate structure analysis by the intermeasurement minimization method
Alexander Dudka
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
MR Hynd et al.
NEUROCHEMISTRY INTERNATIONAL (2004)