期刊
ACS APPLIED MATERIALS & INTERFACES
卷 15, 期 19, 页码 22805-22816出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c21933
关键词
miRNA therapeutics; microRNA-26a; exosome; hydrogel; bone regeneration; tissue engineering
The researchers reported a new therapeutic tool called Exo@miR-26a that can target multiple genes by inducing translation repression and target mRNA degradation. Exo@miR-26a significantly promotes bone regeneration and further facilitates healthy bone regeneration by repressing osteoclast differentiation-related genes.
MicroRNAs (miRNAs) are a new therapeutic tool that can target multiple genes by inducing translation repression and target mRNA degradation. Although miRNAs have gained significant attention in oncology and in work on genetic disorders and autoimmune diseases, their application in tissue regeneration remains hindered by several challenges, such as miRNA degradation. Here, we reported Exosome@MicroRNA-26a (Exo@miR-26a), an osteoinductive factor that can be substituted for routinely used growth factors, which was constructed using bone marrow stem cell (BMSC)-derived exosomes and microRNA-26a (miR-26a). Exo@miR-26a-integrated hydrogels significantly promoted bone regeneration when implanted into defect sites; as the exosome stimulated angiogenesis, miR-26a promoted osteogenesis while the hydrogel enabled a site-directed release. Moreover, BMSC-derived exosomes further facilitated healthy bone regeneration by repressing osteoclast differentiationrelated genes rather than damaging osteoclasts. Taken together, our findings demonstrate the promising potential of Exo@miR-26a for bone regeneration and provide a new strategy for the application of miRNA therapy in tissue engineering.
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