4.8 Article

Writing 3D In Vitro Models of Human Tendon within a Biomimetic Fibrillar Support Platform

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories

Paulina Nunez Bernal et al.

Summary: Organ- and tissue-level biological functions are closely related to microscale cell-cell interactions and tissue architecture. Biofabrication and organoid technologies have the potential to engineer multi-scale living constructs. This study introduces a volumetric bioprinting technique that captures key liver functions. The bioprinting process shapes organoid-laden gelatin hydrogels into complex 3D structures, allowing for rapid printing. Optically tuned bioresins and low stiffness gelatins enhance the viability and metabolism of the bioprinted constructs. This technology opens up new possibilities for regenerative medicine and personalized drug testing.

ADVANCED MATERIALS (2022)

Article Materials Science, Multidisciplinary

Facile Bioprinting Process for Fabricating Size-Controllable Functional Microtissues Using Light-Activated Decellularized Extracellular Matrix-Based Bioinks

Byeongmin Kang et al.

Summary: The concept of microtissues has evolved to create human tissue analogs with physiologically relevant features for advanced therapeutic development. Optimizing biomaterial manufacturing enhances tissue modeling and biofunctional attributes. Developed method utilizing dERS enables single-step bioprinting for microtissue production, promoting tissue maturation and print fidelity.

ADVANCED MATERIALS TECHNOLOGIES (2022)

Review Pharmacology & Pharmacy

The tendon microenvironment: Engineered in vitro models to study cellular crosstalk

Manuel Gomez-Florit et al.

Summary: This review discusses the interaction between tenocytes and other resident cells in the tendon microenvironment, emphasizing the need for advanced in vitro models. These models should be able to mimic the hierarchical architecture, cellularity, and physiological signaling of the tendon niche, as well as recreate the integrated gradients of its tissue interfaces. By leveraging multiple bioengineering technologies, the next generation of relevant in vitro models can be developed to contribute to a deeper understanding of tendon repair mechanisms and the development of more effective treatments.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Review Genetics & Heredity

Human organs-on-chips for disease modelling, drug development and personalized medicine

Donald E. Ingber

Summary: This Review discusses the types of single and multiple human organ-on-a-chip (organ chip) microfluidic devices and their diverse applications for disease modeling, drug development, and personalized medicine. It also addresses the challenges that must be overcome for organ chips to reach their full potential and discusses recent advances in the field.

NATURE REVIEWS GENETICS (2022)

Article Engineering, Biomedical

Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology

Isabel Calejo et al.

Summary: This study successfully fabricated microengineered 3D in vitro models of physiological and pathological tendon states. These innovative models control the fate of human tendon cells through the biological signaling of platelet lysate components and the structure of electrospun microfibers. These models hold promise for drug screening and the development of new therapies.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Biochemistry & Molecular Biology

VEGF promotes tendon regeneration of aged rats by inhibiting adipogenic differentiation of tendon stem/progenitor cells and promoting vascularization

Fan Lai et al.

Summary: The stem cell microenvironment plays a crucial role in stem cell maintenance or differentiation. The expression of IL-10, G-CSF, and VEGF showed significant differences between young and aged rats during patellar tendon repair. VEGF was found to have an inhibitive effect on the adipogenic differentiation of TPSCs. Furthermore, targeting SPP-1 improved the histological score and biomechanical property of aged tendon healing.

FASEB JOURNAL (2022)

Article Chemistry, Multidisciplinary

Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs

Janko Kajtez et al.

Summary: This article presents a modular platform for bioengineering of neuronal networks through direct embedded 3D printing of human stem cells inside Self-Healing Annealable Particle-Extracellular matrix (SHAPE) composites. The developed approach allows precise patterning of human stem cells and generation of mature subtype-specific neurons. Additionally, it enables multi-ink deposition, real-time monitoring of oxygen levels, and creation of vascular-like channels.

ADVANCED SCIENCE (2022)

Review Cell Biology

Advances toward transformative therapies for tendon diseases

Benjamin R. Freedman et al.

Summary: This review article summarizes the latest advancements in the field of tendon disease treatment, highlighting the shift from symptom relief to disease modification and the importance of in-depth research on the disease pathology and establishment of multidiscipline collaboration platforms for the discovery and translation of integrated therapies.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Review Materials Science, Biomaterials

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Scott B. Campbell et al.

Summary: PDMS is commonly used in organ-on-a-chip devices and microphysiological systems due to its ease-of-use, elasticity, and optical transparency, but its limitations in the absorption of small molecules and high-throughput manufacturing have led researchers to explore alternative materials such as elastomers, hydrogels, and thermoplastic polymers. The development of organ-on-a-chip devices based on these alternative materials is trending, with researchers focusing on overcoming obstacles to create versatile devices for personalized medicine and drug discovery.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Article Engineering, Biomedical

3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair

Suhun Chae et al.

Summary: A novel therapeutic platform using 3D cell-printing and tissue-specific bioinks has been established for functional TBI regeneration, showing promising results in promoting TBI healing. This approach offers a new strategy for TBI repair by creating spatially-graded physiology through multi-tissue fibrocartilaginous interface approximation.

BIOFABRICATION (2021)

Review Medicine, General & Internal

Tendinopathy

Neal L. Millar et al.

Summary: Tendinopathy is a complex pathology of the tendon characterized by pain, decline in function, and reduced exercise tolerance. Diagnosis is mainly clinical, but sometimes pain-provoking tests and imaging are necessary. Management includes exercise programmes, therapeutic modalities, and surgical interventions but their effectiveness is still unclear. Future research should focus on understanding key functional pathways in the clinical disease and improving rehabilitation protocols.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Engineering, Biomedical

Driving Hierarchical Collagen Fiber Formation for Functional Tendon, Ligament, and Meniscus Replacement

Jennifer L. Puetzer et al.

Summary: The study successfully demonstrated the development of hierarchical collagen fibers in musculoskeletal tissues using restrained cell-seeded high density collagen gels. The fibers produced were similar to native tissues and showed significant improvement in tensile properties over time. This system holds promise for better understanding cellular regulation of fiber formation and stimulating tissue regeneration after injury.

BIOMATERIALS (2021)

Article Multidisciplinary Sciences

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels

Andrew C. Daly et al.

Summary: Cellular models are essential for studying human development and disease, as well as for screening drug toxicity and efficacy. A bioprinting approach has been developed to transfer spheroids into self-healing support hydrogels, enabling their patterning and fusion into high-cell density microtissues.

NATURE COMMUNICATIONS (2021)

Review Physiology

The Role of Vascular Endothelial Growth Factor in Tendon Healing

Xueli Liu et al.

Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.

FRONTIERS IN PHYSIOLOGY (2021)

Review Cell Biology

The Lack of a Representative Tendinopathy Model Hampers Fundamental Mesenchymal Stem Cell Research

Marguerite Meeremans et al.

Summary: Overuse tendon injuries are a major cause of musculoskeletal morbidity in human and equine athletes, leading to the formation of inferior scar tissue during the healing process. Mesenchymal stem cell (MSC)-based strategies show promise for tendon repair, but the lack of physiologically representative tendinopathy models hinders research progress. Existing in vitro tendon models often lack extracellular tendon matrix and vascular supply, pointing towards the need for improved models to advance MSC therapies for tendon injuries.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Engineering, Biomedical

Comparison of three different acidic solutions in tendon decellularized extracellular matrix bio-ink fabrication for 3D cell printing

Fengyuan Zhao et al.

Summary: The study indicates that different types of acid have different effects on the digestion and dissolution status of dECM hydrogels, and choosing the appropriate acidic solution is a critical factor in the preparation of dECM bio-inks.

ACTA BIOMATERIALIA (2021)

Article Chemistry, Multidisciplinary

3D Bioprinting of Miniaturized Tissues Embedded in Self-Assembled Nanoparticle-Based Fibrillar Platforms

Syeda M. Bakht et al.

Summary: The controlled self-assembly of plant-derived cellulose nanocrystals is combined with 3D bioprinting for the direct biofabrication of microphysiological systems. This approach allows high-resolution bioprinting with arbitrary geometries and tailored permeability for biomacromolecules diffusion and cellular crosstalk, holding structural stability for long-term in vitro cell maturation and offering new opportunities in regenerative medicine.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article

Tendon physiology and repair

Conrad Lee

Orthopaedics and Trauma (2021)

Article Multidisciplinary Sciences

Species variations in tenocytes' response to inflammation require careful selection of animal models for tendon research

Gil Lola Oreff et al.

Summary: This study compared the cellular and molecular features of inflammation in tenocytes of humans and four common model species, finding different animal models have varying degrees of similarity to human tenocytes. Selection of the model species based on specific research questions and combination of data from multiple species will be essential for optimizing translational predictive validity.

SCIENTIFIC REPORTS (2021)

Article Engineering, Biomedical

Extrinsic Macrophages Protect While Tendon Progenitors Degrade: Insights from a Tissue Engineered Model of Tendon Compartmental Crosstalk

Tino Stauber et al.

Summary: Tendons are composed of a functional core of type-I collagen fibers maintained by tenocytes, surrounded by an extrinsic peritendon that contains stem/progenitor cells and blood monocytes. An in vitro model using explanted tendon core stromal tissue surrounded by cell-laden collagen hydrogels is suggested to bridge the gap between in vitro and in vivo models. This model replicates the recruitment of stromal progenitors to the damaged core, leading to an increase in gene expression for tissue degradation, while extrinsic bone-marrow derived macrophages adopt a proresolution phenotype to mitigate tissue breakdown.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Engineering, Biomedical

The rheology of direct and suspended extrusion bioprinting

Megan E. Cooke et al.

Summary: Bioprinting is a promising field for producing implantable tissues and organs, but the availability of functional bioinks is an obstacle to success. Extrusion bioprinting, the most commonly used technique, requires high-viscosity solutions to ensure good shape fidelity of printed tissue constructs. Developments in bioink formulations and the use of suspended printing have been made to overcome rheological limitations.

APL BIOENGINEERING (2021)

Review Engineering, Biomedical

3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

Viraj Mehta et al.

Summary: 3D printing technology has emerged as a promising alternative for fabricating microfluidic devices, overcoming limitations associated with conventional methods. Different manufacturing approaches, along with a wide range of additive manufacturing materials and recent research advancements, have helped address challenges in 3D printed microfluidic devices. Possible implications of 3D printed microfluidics in healthcare, such as in vitro disease modeling, organ modeling, drug development, personalized cancer treatment, and cancer drug screening, are discussed, along with future research directions.

BIO-DESIGN AND MANUFACTURING (2021)

Article Biochemistry & Molecular Biology

Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform

Yimu Zhao et al.

MATRIX BIOLOGY (2020)

Article Engineering, Biomedical

Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures

Barbara B. Mendes et al.

BIOFABRICATION (2020)

Review Chemistry, Multidisciplinary

From Shape to Function: The Next Step in Bioprinting

Riccardo Levato et al.

ADVANCED MATERIALS (2020)

Article Cell Biology

Tendon explant models for physiologically relevant in vitro study of tissue biology - a perspective

Stefania L. Wunderli et al.

CONNECTIVE TISSUE RESEARCH (2020)

Review Biotechnology & Applied Microbiology

3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat

Andrew McCormack et al.

TRENDS IN BIOTECHNOLOGY (2020)

Review Chemistry, Multidisciplinary

Bioprinting: From Tissue and Organ Development to in Vitro Models

Carlos Mota et al.

CHEMICAL REVIEWS (2020)

Review Biotechnology & Applied Microbiology

Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do

Iris Ribitsch et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Engineering, Biomedical

Hyaluronic acid as a bioink for extrusion-based 3D printing

D. Petta et al.

BIOFABRICATION (2020)

Article Nanoscience & Nanotechnology

Tropoelastin-Coated Tendon Biomimetic Scaffolds Promote Stem Cell Tenogenic Commitment and Deposition of Elastin-Rich Matrix

Helena Almeida et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Biotechnology & Applied Microbiology

Mimicking the Articular Joint with In Vitro Models

Susanna Piluso et al.

TRENDS IN BIOTECHNOLOGY (2019)

Review Biotechnology & Applied Microbiology

New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development

Jonathon Parrish et al.

TRENDS IN BIOTECHNOLOGY (2019)

Article Engineering, Biomedical

High density cell seeding affects the rheology and printability of collagen bioinks

Nicole Diamantides et al.

BIOFABRICATION (2019)

Article Multidisciplinary Sciences

The impact of decellularization methods on extracellular matrix derived hydrogels

Julia Fernandez-Perez et al.

SCIENTIFIC REPORTS (2019)

Review Pharmacology & Pharmacy

Blood derivatives awaken in regenerative medicine strategies to modulate wound healing

Barbara B. Mendes et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Pharmacology & Pharmacy

Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing

Magdalena Schneider et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Engineering, Biomedical

Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics

Jinah Jang et al.

BIOMATERIALS (2018)

Article Biochemistry & Molecular Biology

Development of Bioink from Decellularized Tendon Extracellular Matrix for 3D Bioprinting

Burak Toprakhisar et al.

MACROMOLECULAR BIOSCIENCE (2018)

Review Nanoscience & Nanotechnology

Advances in organ-on-a-chip engineering

Boyang Zhang et al.

NATURE REVIEWS MATERIALS (2018)

Review Rheumatology

Inflammatory mechanisms in tendinopathy - towards translation

Neal L. Millar et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Review Surgery

Review: Emerging concepts in the pathogenesis of tendinopathy

Benjamin J. F. Dean et al.

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND (2017)

Article Cell Biology

Tenogenesis of bone marrow-, adipose-, and tendon-derived stem cells in a dynamic bioreactor

Daniel W. Youngstrom et al.

CONNECTIVE TISSUE RESEARCH (2016)

Review Pharmacology & Pharmacy

Biologics for tendon repair

Denitsa Docheva et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

Review Physiology

Tendon Vasculature in Health and Disease

Herbert Tempfer et al.

FRONTIERS IN PHYSIOLOGY (2015)

Article Multidisciplinary Sciences

Human Tendon Stem Cells Better Maintain Their Stemness in Hypoxic Culture Conditions

Jianying Zhang et al.

PLOS ONE (2013)

Review Engineering, Biomedical

An overview of tissue and whole organ decellularization processes

Peter M. Crapo et al.

BIOMATERIALS (2011)

Article Anatomy & Morphology

The Effect of Storage Time on Adipose-Derived Stem Cell Recovery from Human Lipoaspirates

Pedro P. Carvalho et al.

CELLS TISSUES ORGANS (2011)

Article Developmental Biology

Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes

Chisa Shukunami et al.

DEVELOPMENTAL BIOLOGY (2006)

Article Cell & Tissue Engineering

Phenotypic drift in human tenocyte culture

L. Yao et al.

TISSUE ENGINEERING (2006)