4.8 Article

Renal-Clearable Probe with Water Solubility and Photostability for Biomarker-Activatable Detection of Acute Kidney Injuries via NIR-II Fluorescence and Optoacoustic Imaging

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment

Qiong Huang et al.

Summary: Acute kidney injury (AKI) can lead to kidney function loss and increased mortality. This study discovers that ultra-small Tungsten-based nanodots (TWNDs) can be passively targeted for mitochondrial therapy in AKI, showing high effectiveness in reducing mitochondrial ROS and increasing mitophagy.

BIOACTIVE MATERIALS (2023)

Article Chemistry, Physical

Renal clearing carbon dots-based near-infrared fluorescent super-small nanoprobe for renal imaging

Pengli Gao et al.

Summary: Successful preparation of NIR-CDs for real-time renal imaging was achieved, demonstrating high-efficiency renal clearance and reversible clearance in mice models, offering a new tool for imaging analysis of impaired kidney function.

CARBON (2023)

Review Nanoscience & Nanotechnology

Albumin-Consolidated AIEgens for Boosting Glioma and Cerebrovascular NIR-II Fluorescence Imaging

Duyang Gao et al.

Summary: Using endogenous albumin as a matrix, AIE nanoprobes show improved fluorescence quantum yield and active targeting abilities in diagnosing brain diseases.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Analytical

Detection of Kidney Dysfunction through In Vivo Magnetic Resonance Imaging with Renal-Clearable Gadolinium Nanoprobes

Jun Wang et al.

Summary: This research successfully synthesized a class of renal-clearable gadolinium nanoparticles and achieved the diagnosis of kidney dysfunction in a mice model with a damaged kidney through noninvasive magnetic resonance imaging. This provides a new tool for exploring translational strategies for kidney dysfunction.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

A Bright, Renal-Clearable NIR-II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging

Chenzhi Yao et al.

Summary: A new aza-boron-dipyrromethene (aza-BODIPY) brush macromolecular probe (FBP 912) with high brightness and renal clearance efficiency has been developed for non-invasive diagnosis of kidney diseases. This probe shows superior performance compared to traditional fluorophores in passive targeted imaging of tumors and active targeted imaging of renal cell carcinoma.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Engineering, Biomedical

Electron-acceptor density adjustments for preparation conjugated polymers with NIR-II absorption and brighter NIR-II fluorescence and 1064 nm active photothermal/gas therapy

Pengfei Sun et al.

Summary: Designing conjugated polymers with efficient NIR-II fluorescence and photothermal therapy performance is challenging. This study addresses the issue by adjusting the electron acceptor density, leading to enhanced fluorescence and photothermal effects. Nanoparticles based on these polymers exhibit high brightness fluorescence and photothermal conversion efficiency.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Near infrared light triggered ternary synergistic cancer therapy via L-arginine-loaded nanovesicles with modification of PEGylated indocyanine green

Kesi Wang et al.

Summary: In this study, a nano-vesicular system IA-PEP was developed to efficiently deliver photosensitizer PEGylated indocyanine green and NO donor L-Arg, achieving a ternary synergistic treatment combining NO therapy, photodynamic therapy, and mild-temperature photothermal therapy under 808 nm laser irradiation. The potent anti-tumor efficacy of IA-PEP with complete tumor elimination was verified in vivo in nude mice bearing xenograft MCF-7 tumors.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Analytical

An activatable probe for detection and therapy of food-additive-related hepatic injury via NIR-II fluorescence/optoacoustic imaging and biomarker-triggered drug release

Cheng Zeng et al.

Summary: Food additives play an important role in ensuring the safety of processed foods, but nitrites can generate toxic nitrosamines, causing liver damage. This study presents an activatable probe for detecting nitrosamine-induced acute liver injury and releasing drugs for therapy.

ANALYTICA CHIMICA ACTA (2022)

Article Chemistry, Multidisciplinary

Counterion-Paired Bright Heptamethine Fluorophores with NIR-II Excitation and Emission Enable Multiplexed Biomedical Imaging

Yang Yang et al.

Summary: This study developed a series of heptamethine cyanines with varied absorption/emission maxima in the NIR-II spectral window. The utilization of bulky counterions significantly improved absorptivity, brightness, and spectral profiles in water, addressing the quenching problem of NIR-II cyanines. The developed cyanines showed promising potential for non-invasive bioimaging in various applications.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Engineering, Biomedical

An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome

Lihe Sun et al.

Summary: In this study, an oral-administration nanosystem (QM@EP) for the detection, targeted delivery, and therapy of ulcerative colitis was developed. The nanosystem successfully delivered the probe and drug to the colon and released them upon the stimulation of colonic pH. The released probe exhibited strong fluorescence for imaging and the released drug showed high therapeutic efficacy against ulcerative colitis.

BIOMATERIALS (2022)

Article Engineering, Biomedical

Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury

Weimin Tang et al.

Summary: This study demonstrates the synthesis of a novel siRNA carrier, C-CS, which shows potential for targeted delivery to injured kidneys. The C-CS/siRNA nanoparticles effectively accumulate and deliver therapeutic siRNAs to injured kidneys through CXCR4 binding, providing a new approach for AKI therapy.

BIOMATERIALS (2022)

Review Chemistry, Inorganic & Nuclear

Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging

Juan Ouyang et al.

Summary: Fluorophores with aggregation-induced emission (AIE) have many advantageous features for biomedical applications, especially for early diagnosis of diseases. Probes play a crucial role in fluorescent and optoacoustic imaging, and biomarker-activatable probes based on smart AIEgens have been widely researched and applied in this field.

COORDINATION CHEMISTRY REVIEWS (2022)

Article Multidisciplinary Sciences

Identification of kidney injury-released circulating osteopontin as causal agent of respiratory failure

Fatima Zohra Khamissi et al.

Summary: This study identifies circulating osteopontin (OPN) released from kidney tubule cells as a novel mediator in acute kidney injury (AKI)-induced acute lung injury (ALI). OPN triggers lung endothelial leakage, inflammation, and respiratory failure. The study also demonstrates the elevated levels of OPN in AKI patients and its correlation with kidney injury.

SCIENCE ADVANCES (2022)

Article Chemistry, Analytical

Small-Molecule Photoacoustic Imaging Probe with Aggregation-Enhanced Amplitude for Real-Time Visualization of Acute Kidney Injury

Wangning Zhang et al.

Summary: In this study, a small-molecule photoacoustic (PA) probe (BDP-3) was designed and synthesized, and it was found that BDP-3 can transform into renal clearable nanoaggregates under physiological conditions. This transformation process not only increases its PA amplitude but also exhibits higher sensitivity, demonstrating the potential of this probe for noninvasive detection of acute kidney injury.

ANALYTICAL CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

H2O2-Activatable Antioxidant Polymeric Prodrug Nanoparticles for the Prevention of Renal Ischemia/Reperfusion Injury

Hyeonbin Shin et al.

Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).

BIOMACROMOLECULES (2022)

Article Multidisciplinary Sciences

Bioorthogonally activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging

Xianghan Zhang et al.

Summary: This article presents a method for expanding the repertoire of responsive dyes in biorthogonal chemistry by developing a near-infrared fluorophore that turns on its fluorescence upon biorthogonal reaction. The study discovers a design mechanism for the construction of bioorthogonally activatable NIR fluorophores and demonstrates their potential in sensitive in vivo imaging of tumors.

NATURE COMMUNICATIONS (2022)

Article Nanoscience & Nanotechnology

Quantum Dot-Based Micromotors with NIR-I Light Photocatalytic Propulsion and NIR-II Fluorescence

Jiajia Wang et al.

Summary: Here, we report the first PbS quantum dot (QD)-based micromotors that can be propelled through NIR-I light-driven photocatalysis and exhibit NIR-II fluorescence. The propulsion performance of these Cu2O@PbS micromotors is enhanced by the doping of NIR-I PbS QDs, which increase the absorption efficiency and inhibit recombination of photogenerated electron-hole pairs. Additionally, the presence of NIR PbS QDs allows for prominent and stable NIR-II fluorescence, offering potential for in vivo visualization of the micromotors' position.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Nanoscience & Nanotechnology

Surface Plasmon-Enhanced NIR-II Fluorescence in a Multilayer Nanoprobe for Through-Skull Mouse Brain Imaging

Lan Peng et al.

Summary: This study describes a surface plasmon-enhanced NIR-II fluorescence strategy, incorporating silica-coated gold nanorods and polymer dots into a multilayer nanostructure, achieving fluorescence enhancement in the NIR-II imaging window. This approach demonstrates superior signal-to-background ratio and penetration depth in mouse brain imaging.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Multidisciplinary

BOIMPY-Based NIR-II Fluorophore with High Brightness and Long Absorption beyond 1000 nm for In Vivo Bioimaging: Synergistic Steric Regulation Strategy

Hu Xiong et al.

Summary: This study reports a new D-A-D type BOIMPY-based NIR-II dye (NK1143) with improved brightness for in vivo bioimaging. The dye showed deep optical penetration and high-resolution blood vessel imaging. Additionally, the dye nanoprobe demonstrated effective targeting and visualization of various tumor xenografts, enabling precise resection of tiny metastases.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

A Water-Soluble AIEgen for Noninvasive Diagnosis of Kidney Fibrosis via SWIR Fluorescence and Photoacoustic Imaging

Dingyuan Yan et al.

Summary: By utilizing AIE-4PEG550 NPs, researchers have developed a method for longitudinally visualizing the progression of renal fibrosis in the early stage using short-wave infrared fluorescence and photoacoustic bimodal imaging. The nanosized fluorophore demonstrates excellent imaging performance, high renal clearance efficiency, and good biocompatibility, making it superior to current clinical diagnostic assays.

ADVANCED MATERIALS (2022)

Article Chemistry, Analytical

Water-Dispersible Activatable Nanoprobe for Detecting Cadmium-Ion-Induced Oxidative Stress in Edible Crops via Near-Infrared Second-Window Fluorescence Imaging

Cheng Zeng et al.

Summary: Edible crops are vital for food security and sustainable agriculture. However, contamination of water and soil by heavy metal ions, especially cadmium (Cd), can have detrimental effects on the growth of these crops. Cd is widely used in industries and has become the most important metal ion in soil and water pollution. When Cd ions enter edible crops, it induces oxidative stress, which inhibits their growth. Therefore, accurately monitoring oxidative stress induced by Cd ions in edible crops is of great significance.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Kidney-Targeted Nanoparticles Loaded with the Natural Antioxidant Rosmarinic Acid for Acute Kidney Injury Treatment

Jiajia Li et al.

Summary: This study developed a nanoparticle for targeted delivery of rosmarinic acid (RA) in the treatment of acute kidney injury (AKI). The nanoparticle showed excellent antioxidative and antiapoptotic effects, improved renal function, and repaired damaged renal tissue in vivo.
Article Multidisciplinary Sciences

Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

Letizia De Chiara et al.

Summary: In this study, the distribution of polyploid tubular cells (TC) during acute kidney injury (AKI) was characterized using DNA content analysis and single cell RNA-sequencing. It was found that YAP1-driven TC polyploidization outside the site of injury is a mechanism to sustain residual kidney function during early AKI. However, polyploid TC senescence promotes interstitial fibrosis and CKD in AKI survivors. Targeting TC polyploidization after the early AKI phase prevents AKI-CKD transition without affecting AKI lethality. Senolytic treatment blocks repeated TC polyploidization cycles and prevents CKD.

NATURE COMMUNICATIONS (2022)

Article Engineering, Biomedical

A Biomarker-Responsive Nanosystem with Colon-Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR-II Fluorescence Imaging

Zhuo Zeng et al.

Summary: A novel nanosystem (BM@EP) has been developed for detection and therapy of ulcerative colitis (UC). The system can be activated in the colon, releasing the drug and enabling diagnosis and recovery evaluation.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment

Zhixin Chen et al.

Summary: This study reports the use of hydrogen-terminated germanene nanosheets as an antioxidative defense nanoplatform against acute kidney injury (AKI). The results show that H-germanene can effectively scavenge reactive oxygen species (ROS) and accumulate in injured kidneys, providing a potential treatment option for renal diseases.

ADVANCED SCIENCE (2022)

Review Chemistry, Multidisciplinary

The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications

Xuan Zhao et al.

Summary: Polymethine cyanine dyes have attracted increasing attention in fluorescent bioimaging applications due to their high molar extinction coefficients, intensive fluorescence brightness, and flexible wavelength tunability. Recent advances in the development of NIR-II polymethine fluorophores have focused on improving optical performance, including tunable fluorescence, improved brightness, water solubility, and stability. This review summarizes the molecular tailoring design strategies and highlights representative bioimaging and biosensing applications. The potential challenges and perspectives of NIR-II polymethine fluorophores in this emerging field are also discussed.

CHEMICAL SCIENCE (2022)

Article Chemistry, Multidisciplinary

Hyperfluorescence Imaging of Kidney Cancer Enabled by Renal Secretion Pathway Dependent Efflux Transport

Bujie Du et al.

Summary: The study demonstrated that utilizing renal tubular secretion pathway for near-infrared fluorescence imaging of kidney cancer using ICG-PEG45 has potential applications. By tuning elimination pathways and utilizing different efflux kinetics of medical agents in normal and diseased tissues, a new strategy for addressing challenges in disease diagnosis and treatments can be developed.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Nanoscience & Nanotechnology

Mitochondria-Targeting MoS2-Based Nanoagents for Enhanced NIR-II Photothermal-Chemodynamic Synergistic Oncotherapy

Xiao Li et al.

Summary: MPFPT nanosheets demonstrate enhanced therapeutic efficacy by targeting mitochondria, good photothermal performance, and acceleration of the Fenton reaction, making them promising nanoagents for oncotherapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Analytical

NIR-II Fluorescent Biodegradable Nanoprobes for Precise Acute Kidney/Liver Injury Imaging and Therapy

Xiaoguang Ge et al.

Summary: We developed novel NIR-II emitting and therapeutic BPQDs with excellent biodegradability vivo, providing a promising candidate for NIR-II FL imaging and ROS scavenging. Adjusting the size of nanoparticles, BPQDs can specifically accumulate in the kidney or liver. A low dosage of BPQDs can effectively protect tissues from ROS-mediated damage in acute kidney and liver injury, real-time monitored by responsive NIR-II fluorescence imaging.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Analytical

Real-Time Monitoring Renal Impairment Due to Drug-Induced AKI and Diabetes-Caused CKD Using an NAG-Activatable NIR-II Nanoprobe

Jiahui Tan et al.

Summary: A new fluorescent nanoprobe has been developed for real-time imaging of kidney function, providing high resolution imaging in living mice and showing potential for early diagnosis of renal diseases such as AKI and CKD. The nanoprobe is sensitive and specific for detecting AKI and CKD, allowing for noninvasive detection of disease onset at least 32 hours earlier than existing assays.

ANALYTICAL CHEMISTRY (2021)

Article Biophysics

6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green

Qiang Hu et al.

Summary: A novel amphiphilic mPEG-ACA-ICG conjugate was successfully constructed by modifying ICG with a hydrophobic linker ACA and mPEG, showing improved stability and photothermal conversion efficiency. The nanomicelles exhibited great potential for tumor photothermal therapy and fluorescence image-guided surgery.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Chemistry, Multidisciplinary

Harnessing Hypoxia-Dependent Cyanine Photocages for In Vivo Precision Drug Release

Yutao Zhang et al.

Summary: Researchers have developed a hypoxia-dependent photoactivation mechanism for precise manipulation of biological events and in vivo feedback regulation. This novel approach overcomes the limitation of oxygen-dependence in current near-infrared photocages, expanding the toolbox for targeted therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Multidisciplinary Sciences

A2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging

Junjie Chen et al.

Summary: The research team developed an activatable nanoprobe by linking a benzothiadiazole core with specific groups, which can be cleaved and activated at disease sites, generating fluorescent emission and ultrasound signal for multi-mode imaging for detection and imaging.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Sequential Therapy of Acute Kidney Injury with a DNA Nanodevice

Qian Chen et al.

Summary: The development of a renal-accumulating DNA nanodevice in this study offers promising protection for acute kidney injury patients in different stages, with potential for providing durable and pathogenic treatment for kidney dysfunction based on the pathophysiological events caused by ischemia-reperfusion.

NANO LETTERS (2021)

Review Endocrinology & Metabolism

Optoacoustic imaging in endocrinology and metabolism

Angelos Karlas et al.

Summary: Optoacoustic imaging technology plays a crucial role in endocrinology and metabolism, allowing non-invasive and label-free imaging of the structure and function of organs, tissues, and cells. Optoacoustic imaging can visualize endocrine physiology and disease at different scales, revealing tissue vasculature, oxygenation, metabolic activity, and inflammation.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Article Chemistry, Multidisciplinary

A Targeted Nanosystem for Detection of Inflammatory Diseases via Fluorescent/Optoacoustic Imaging and Therapy via Modulating Nrf2/NF-κB Pathways

Juan Ouyang et al.

Summary: By developing a multifunctional nanosystem, active targeting, activatable imaging, and on-demand therapy against inflammatory diseases can be achieved through precise modulation of inflammatory signaling pathways.
Article Multidisciplinary Sciences

A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress

Pietro Cacialli et al.

Summary: The study found that reducing ROS levels in HSPCs is crucial for the expansion of hematopoietic stem cells in the fetal liver, and antioxidants can rescue the damage caused by excessive ROS. CX41.8 and ifi30 play important roles in reducing ROS levels in HSPCs in the hematopoietic niche.

NATURE COMMUNICATIONS (2021)

Article Medicine, General & Internal

Acute kidney injury

John A. Kellum et al.

Summary: Acute kidney injury (AKI) describes a sudden loss of kidney function which can lead to long term damage. AKI and AKD are global issues with different causes and management strategies in various regions. Prevention and early detection of AKI are crucial for better outcomes.

NATURE REVIEWS DISEASE PRIMERS (2021)

Review Chemistry, Multidisciplinary

Emerging contrast agents for multispectral optoacoustic imaging and their biomedical applications

Yinglong Wu et al.

Summary: Optoacoustic imaging is a hybrid biomedical imaging technique that uses contrast agents to generate ultrasound waves in tissues, producing high-resolution images. Multispectral optoacoustic imaging can discriminate signals from different contrast agents and enable specific agent identification in tissues, as well as simultaneous molecular and physiological imaging. Contrast agents play essential roles in optoacoustic imaging, with various new agents being explored and applied in recent years.

CHEMICAL SOCIETY REVIEWS (2021)

Article Materials Science, Biomaterials

An anti-aggregation NIR-II heptamethine-cyanine dye with a stereo-specific cyanine for imaging-guided photothermal therapy

Hongyun Qian et al.

Summary: The hydrophilic quaternary stereo-specific cyanine (HQS-Cy) dye increases water solubility and biocompatibility, while the polypeptide-based nanoparticles encapsulate the dye to further enhance water solubility. The HQS-Cy@P NPs show excellent photothermal stability and high photothermal conversion efficiency, making it an efficient system for NIR-II imaging-guided photothermal therapy of cancer both in vitro and in vivo.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Chemistry, Multidisciplinary

Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases

Jiaguo Huang et al.

Summary: Near-infrared (NIR) fluorescence imaging shows great potential in both basic biomedical research and clinical practice, especially in the diagnosis of nephron-urological diseases. The development of molecular probes has improved detection specificity and contrast enhancement in imaging.

CHEMICAL SCIENCE (2021)

Article Medicine, Research & Experimental

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao et al.

Summary: Reducing mtROS levels attenuated renal dysfunction, mitochondrial damage, and inflammation in IRI-AKI mice. The loss of TFAM can impact mtDNA maintenance, mitochondrial energy metabolism, and cytokine release. Insights into the role of mtROS and TFAM in IRI-AKI provide potential therapeutic targets for renal repair.

THERANOSTICS (2021)

Article Chemistry, Multidisciplinary

Treating Acute Kidney Injury with Antioxidative Black Phosphorus Nanosheets

Junjun Hou et al.

NANO LETTERS (2020)

Review Urology & Nephrology

Long-term outcomes of acute kidney injury and strategies for improved care

Matthew T. James et al.

NATURE REVIEWS NEPHROLOGY (2020)

Article Chemistry, Multidisciplinary

Fluoro-Photoacoustic Polymeric Renal Reporter for Real-Time Dual Imaging of Acute Kidney Injury

Penghui Cheng et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

Sterically Shielded Heptamethine Cyanine Dyes for Bioconjugation and High Performance Near-Infrared Fluorescence Imaging

Dong-Hao Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Near-Infrared Chemiluminescent Reporters for In Vivo Imaging of Reactive Oxygen and Nitrogen Species in Kidneys

Jingsheng Huang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Chemistry, Multidisciplinary

Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Chunyan Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Nanoscience & Nanotechnology

Active-Targeting NIR-II Phototheranostics in Multiple Tumor Models Using Platelet-Camouflaged Nanoprobes

Xiaorui Geng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Multidisciplinary Sciences

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Shangfeng Wang et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation

Pietro E. Cippa et al.

NATURE COMMUNICATIONS (2019)

Article Chemistry, Physical

Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury

Jiaguo Huang et al.

NATURE MATERIALS (2019)

Article Chemistry, Multidisciplinary

A Renal-Clearable Duplex Optical Reporter for Real-Time Imaging of Contrast-Induced Acute Kidney Injury

Jiaguo Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Multidisciplinary

Renal-clearable Molecular Semiconductor for Second Near-Infrared Fluorescence Imaging of Kidney Dysfunction

Jiaguo Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm

Caixia Sun et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Biochemistry & Molecular Biology

Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy

Adrian P. Regensburger et al.

NATURE MEDICINE (2019)

Article Medicine, Research & Experimental

Highly-Soluble Cyanine J-aggregates Entrapped by Liposomes for In Vivo Optical Imaging around 930 nm

Dyego Miranda et al.

THERANOSTICS (2019)

Review Urology & Nephrology

Global epidemiology and outcomes of acute kidney injury

Eric A. J. Hoste et al.

NATURE REVIEWS NEPHROLOGY (2018)

Article Multidisciplinary Sciences

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Dalong Ni et al.

NATURE COMMUNICATIONS (2018)

Review Urology & Nephrology

Understanding and preventing contrast-induced acute kidney injury

Michael Faehling et al.

NATURE REVIEWS NEPHROLOGY (2017)

Article Chemistry, Physical

A small-molecule dye for NIR-II imaging

Alexander L. Antaris et al.

NATURE MATERIALS (2016)

Review Urology & Nephrology

Pathophysiology of ischemic acute kidney injury

Asif A. Sharfuddin et al.

NATURE REVIEWS NEPHROLOGY (2011)

Review Urology & Nephrology

Contrast-induced acute kidney injury and diabetic nephropathy

Andrew D. Calvin et al.

NATURE REVIEWS NEPHROLOGY (2010)