期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 74, 期 4, 页码 685-692出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2015.10.046
关键词
acrodermatitis chronica atrophicans; Borrelia burgdorferi; borreliosis; granuloma annulare; lichenoid dermatitis; plasma cells
类别
资金
- Societe Francaise de Dermatologie grant
Background: The diagnosis of acrodermatitis chronica atrophicans (ACA), the late cutaneous manifestation of Lyme borreliosis, can be challenging. Histologic changes in ACA have been described in a few studies from endemic countries, relying on cases documented by serology only. Objectives: We sought to reassess the clinicopathological spectrum of ACA in a series of thoroughly documented cases. Methods: Patients prospectively included in a national prospective study were selected on the basis of positive culture and/or polymerase chain reaction of a skin biopsy sample. The diagnosis of ACA was confirmed by reviewing the clinical and serologic data. Histopathological samples were carefully reviewed. Results: Twenty patients were included. Unusual clinical features (ie, numerous small violaceous patches and equidistant small spinous papules with background faint erythema) were observed in 2 patients. Histopathological examination revealed a classic plasma cellerich perivascular and interstitial pattern with telangiectases in 16 of 25 samples, whereas strikingly prominent granuloma annulareelike or lichenoid features were observed in 4 and 2 of 25 cases, respectively, and discrete nonspecific minor changes in 3 of 25 cases. Limitations: The small number of patients was a limitation. Conclusions: Genuine culture-and/or polymerase chain reactioneproven ACA can rarely present as numerous violaceous patches or cluster of spinous papules clinically, and as a granuloma annulareelike or lichenoid dermatosis histologically.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据