期刊
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
卷 55, 期 7, 页码 618-626出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jaac.2016.04.013
关键词
autism spectrum disorders; fMRI; resting state; salience network; sensory overresponsivity
资金
- National Institute of Child Health and Human Development [P50 HD055786]
- National Institute of Mental Health [1 R01 HD065280-01]
- National Institute of Health National Research Service Award predoctoral fellowship [F32MH105167-01]
- Brain Mapping Medical Research Organization
- Brain Mapping Support Foundation
- Pierson-Lovelace Foundation
- Ahmanson Foundation
- William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation
- Tamkin Foundation
- Jennifer Jones-Simon Foundation
- Capital Group Companies Charitable Foundation
- Robson Family
- North Star Fund
- National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [RR12169, RR13642, RR00865]
Objective: The salience network, an intrinsic brain network thought to modulate attention to internal versus external stimuli, has been consistently found to be atypical in autism spectrum disorders (ASD). However, little is known about how this altered resting-state connectivity relates to brain activity during information processing, which has important implications for understanding sensory overresponsivity (SOR), a common and impairing condition in ASD related to difficulty downregulating brain responses to sensory stimuli. This study examined how SOR in youth with ASD relates to atypical salience network connectivity and whether these atypicalities are associated with abnormal brain response to basic sensory information. Method: Functional magnetic resonance imaging was used to examine how parent-rated SOR symptoms related to salience network connectivity in 61 youth (aged 8-17 years; 28 with ASD and 33 IQ-matched typically developing youth). Correlations between resting-state salience network connectivity and brain response to mildly aversive tactile and auditory stimuli were examined. Results: SOR in youth with ASD was related to increased resting-state functional connectivity between salience network nodes and brain regions implicated in primary sensory processing and attention. Furthermore, the strength of this connectivity at rest was related to the extent of brain activity in response to auditory and tactile stimuli. Conclusion: Results support an association between intrinsic brain connectivity and specific atypical brain responses during information processing. In addition, findings suggest that basic sensory information is overly salient to individuals with SOR, leading to overattribution of attention to this information. Implications for intervention include incorporating sensory coping strategies into social interventions for individuals with SOR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据