Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus

B cells and autoantibodies have well-described pathological roles in systemic lupus erythematosus (SLE). Bradford et al.(1) now provide evidence that autoantibodies can also be protective by neutralizing type I interferons (IFNs) and restraining the activation of pathogenic B cells.

Automated summary

The study reveals that autoantibodies in systemic lupus erythematosus (SLE) can have a protective role by neutralizing type I interferons (IFNs) and restraining the activation of pathogenic B cells.