Particle beam therapy for nasopharyngeal cancer: A systematic review and meta-analysis

Article Otorhinolaryngology

Intensity-modulated proton radiation therapy as a radical treatment modality for nasopharyngeal carcinoma in China: A cost-effectiveness analysis

Guo Li et al.

Summary: The study showed that compared to IMRT, IMPT has the potential to reduce toxicities and maintain tumor control for NPC patients, especially in Chinese patients where it may be cost-effective.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2022)

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Article Oncology

A Decision Support Tool to Optimize Selection of Head and Neck Cancer Patients for Proton Therapy

Makbule Tambas et al.

Summary: A decision support tool has been developed to select head and neck cancer patients for proton therapy. The tool predicts the reduction in expected toxicity risk with proton therapy using delineation data and can be used before treatment planning. The tool has a positive predictive value of over 90%, reducing treatment delays significantly.

CANCERS (2022)

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Article Otorhinolaryngology

Proton pencil-beam scanning radiotherapy in the treatment of nasopharyngeal cancer: dosimetric parameters and 2-year results

Jiri Kubes et al.

Summary: Patients with nasopharyngeal cancer treated with proton pencil-beam scanning radiotherapy showed promising treatment outcomes and mild acute toxicity. The study highlighted the feasibility of proton therapy in this group of patients with advanced disease.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas

Hideki Minatogawa et al.

Summary: Comparing adaptive intensity-modulated proton beam therapy (A-IMPT) with adaptive intensity-modulated X-ray therapy (A-IMXT) for nasopharyngeal carcinomas (NPC), it was found that A-IMPT significantly reduced the doses to multiple organs compared to A-IMXT. In both treatment methods, the mean doses to the oral cavity, supraglottic larynx, and glottic larynx were significantly reduced.

JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Brain-Specific Relative Biological Effectiveness of Protons Based on Long-term Outcome of Patients With Nasopharyngeal Carcinoma

Ying Y. Zhang et al.

Summary: This study aimed to determine the RBE for temporal lobe radiographic changes in nasopharyngeal carcinoma patients using long-term follow-up data, with an RBE of 1.18 calculated. The study found that tolerance doses for proton treatments were lower than that of photon treatments at all dose levels. Further prospective studies in larger cohorts are needed to confirm these findings.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Pretreatment 18F-FDG uptake heterogeneity can predict treatment outcome of carbon ion radiotherapy in patients with locally recurrent nasopharyngeal carcinoma

Guang Ma et al.

Summary: The study examined the value of pretreatment F-18-FDG uptake heterogeneity in predicting the prognosis of locally recurrent nasopharyngeal carcinoma (LRNPC) patients treated with carbon ion radiotherapy (CIRT). Results showed that F-18-FDG uptake heterogeneity, particularly with a HI>=0.81, was significantly associated with poorer LRFS and PFS outcomes, indicating its potential as an independent predictor for LRNPC patients undergoing CIRT.

ANNALS OF NUCLEAR MEDICINE (2021)

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Article Oncology

Intensity Modulated Proton Beam Therapy versus Volumetric Modulated Arc Therapy for Patients with Nasopharyngeal Cancer: A Propensity Score-Matched Study

Yung-Chih Chou et al.

Summary: IMPT may provide better oncologic outcomes compared to VMAT in patients with nasopharyngeal carcinoma, with reduced rates of NG tube insertion and body weight loss, but it also increases the risk of grade III radiation dermatitis.

CANCERS (2021)

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Article Medicine, General & Internal

Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy

Xingzhe Li et al.

Summary: This study compared the toxic effects and oncologic outcomes of patients with nonmetastatic NPC treated with IMPT vs IMRT with or without chemotherapy. The results showed that IMPT was associated with lower acute toxicity burden compared with IMRT, rare late complications, and excellent oncologic outcomes, including 100% locoregional control at 2 years.

JAMA NETWORK OPEN (2021)

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Article Oncology

Intensity-Modulated Proton Therapy for Nasopharynx Cancer: 2-year Outcomes from a Single Institution

Vonetta M. Williams et al.

Summary: Advances in radiotherapy have improved tumor control and reduced toxicity in the management of nasopharyngeal carcinoma. Proton therapy with intensity-modulated proton therapy (IMPT) has shown potential in improving therapeutic ratio for NPC. The 2-year clinical outcomes with IMPT for NPC demonstrated excellent local regional control and favorable toxicity profile, supporting its clinical use.

INTERNATIONAL JOURNAL OF PARTICLE THERAPY (2021)

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Article Oncology