期刊
ACS APPLIED BIO MATERIALS
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.2c00956
关键词
antibacterial surfaces; titanium dioxide nanoparticles; microstructured surfaces; photocatalysis; bacteria inactivation
This study demonstrates an innovative approach to enhance antibacterial surfaces by incorporating titanium dioxide nanoparticles into microstructured surfaces. The engineered surfaces effectively reduced bacterial colonization through a combination of UVC disinfection and TiO2 photocatalysis. The results suggest that this synergistic strategy holds great potential for various applications in healthcare and biotechnology markets.
Bacterial colonization and biofilm formation are found on nearly all wet surfaces, representing a serious problem for both human healthcare and industrial applications, where traditional treatments may not be effective. Herein, we describe a synergistic approach for improving the performance of antibacterial surfaces based on microstructured surfaces that embed titanium dioxide nanoparticles (TiO2 NPs). The surfaces were designed to enhance bacteria entrapment, facilitating their subsequent eradication by a combination of UVC disinfection and TiO2 NPs photocatalysis. The efficacy of the engineered TiO2-modified microtopographic surfaces was evaluated using three different designs, and it was found that S2-lozenge and S3-square patterns had a higher concentration of trapped bacteria, with increases of 70 and 76%, respectively, compared to flat surfaces. Importantly, these surfaces showed a significant reduction (99%) of viable bacteria after just 30 min of irradiation with UVC 254 nm light at low intensity, being sixfold more effective than flat surfaces. Overall, our results showed that the synergistic effect of combining microstructured capturing surfaces with the chemical functionality of TiO2 NPs paves the way for developing innovative and efficient antibacterial surfaces with numerous potential applications in the healthcare and biotechnology market.
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