期刊
ACS APPLIED BIO MATERIALS
卷 6, 期 2, 页码 784-792出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.2c00965
关键词
radiosensitizer; gadolinium; gold; nanoparticle; radiotherapy; bimetallic
Radiation therapy shows promising effectiveness against various cancers, and nanoparticles of high-atomic-number (high-Z) materials can enhance X-ray radiation therapy. In this study, bovine serum albumin capped gadolinium oxide and gold nanoparticles (Gd2O3@BSA-Au NPs) are developed as a bimetallic radiosensitizer to maximize radiation therapy within tumors. In vitro tests and evaluation in a breast cancer murine model confirm the radiosensitizing ability of the nanoparticles. Applying Gd2O3@BSA-Au NPs under X-ray irradiation significantly improves cancer therapy efficacy, as evidenced by studies on cell viability, proliferation, reactive oxygen species production, and in vivo anti-tumor effect.
Radiation therapy has demonstrated promising effectiveness against several types of cancers. X-ray radiation therapy can be made further effective by utilizing nanoparticles of high-atomic-number (high-Z) materials that act as radiosensitizers. Here, in purpose of maximizing the radiation therapy within tumors, bovine serum albumin capped gadolinium oxide and gold nanoparticles (Gd2O3@BSA-Au NPs) are developed as a bimetallic radiosensitizer. In this study, we incorporate two high-Z-based nanoparticles, Au and Gd, in a single nanoplatform. The radiosensitizing ability of the nanoparticles was assessed with a series of in vitro tests, following evaluation in vivo in a breast cancer murine model. Enhanced tumor suppression is observed in the group that received radiation after administration of Gd2O3@BSA-Au NPs. As a result, cancer therapy efficacy is significantly improved by applying Gd2O3@BSA-Au NPs under X-ray irradiation, as evidenced by studies evaluating cell viability, proliferation, reactive oxygen species production, and in vivo anti-tumor effect.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据