期刊
EPILEPSIA OPEN
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/epi4.12662
关键词
case report form; lipidome; metabolome; omic data processing; preclinical; proteome; rodent
资金
- American Epilepsy Society (AES)
- International League Against Epilepsy (ILAE)
The International League Against Epilepsy/American Epilepsy Society established the TASK3 working groups to create common data elements for preclinical epilepsy research. This paper discusses the important elements for proteomics, lipidomics, and metabolomics methodologies and provides a rationale for documenting parameters.
The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. This is the second in a two-part series of omics papers, with the other including genomics, transcriptomics, and epigenomics. The aim of the CDEs was to improve the standardization of experimental designs across a range of epilepsy research-related methods. We have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for proteomics, lipidomics, and metabolomics of samples from rodent models and people with epilepsy. We discuss the important elements that need to be considered for the proteomics, lipidomics, and metabolomics methodologies, providing a rationale for the parameters that should be documented.
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