Applications of Extracellular Vesicles in Nervous System Disorders: An Overview of Recent Advances

Article Engineering, Biomedical

Endoscope image mosaic based on pyramid ORB

Ziyan Zhang et al.

Summary: This paper introduces an improved ORB algorithm using Gaussian Pyramid for endoscopic image mosaic, which achieves high accuracy, efficiency, and real-time performance.

BIOMEDICAL SIGNAL PROCESSING AND CONTROL (2022)

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Review Environmental Sciences

Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery

Chenmala Karthika et al.

Summary: Alzheimer's disorder is difficult to manage and treat due to the complexity of the brain and the blood-brain barrier. A combined strategy using a nano-based formulation containing vitamin E, quercetin, and basil oil, administered nasally, shows promise in treating and alleviating Alzheimer's disease. Intranasal drug administration is a non-invasive approach that enhances bioavailability and bypasses the blood-brain barrier, reducing systemic side effects.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Biotechnology & Applied Microbiology

sEVsRVG selectively delivers antiviral siRNA to fetus brain, inhibits ZIKV infection and mitigates ZIKV- induced in mouse model

Rui Zhang et al.

Summary: The research team has developed a targeted antiviral therapy system based on sEVs to combat ZIKV-induced neurological disorders and fetal brain infections. This system utilizes specific siRNA and neuron-targeting proteins, effectively preventing infection in fetal mouse brains and alleviating neuroinflammation and neurological damage caused by ZIKV.

MOLECULAR THERAPY (2022)

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Article Biotechnology & Applied Microbiology

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Eric Karran et al.

Summary: Clinical trial data for drugs targeting Aβ in Alzheimer's disease suggest that reducing amyloid plaque to a low level may reveal significant clinical benefit, but there may be a time lag between plaque removal and observable clinical benefit. The speed of amyloid removal from the brain by a potential therapy will be crucial in demonstrating clinical benefit in a clinical trial setting.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Clinical Neurology

Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities

Zahinoor Ismail et al.

Summary: Psychosis is a common and distressing symptom in people with Alzheimer's disease, but there are limited treatment options. Recent research has provided new insights into evaluating and treating psychosis, including incorporating the emergence of psychotic symptoms in older adults into research frameworks and the latest findings in genomics and neuroimaging.

NATURE REVIEWS NEUROLOGY (2022)

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Article Respiratory System

Altered distribution, activation and increased IL-17 production of mucosal-associated invariant T cells in patients with acute respiratory distress syndrome

Tae-Ok Kim et al.

Summary: The study demonstrates that circulating MAIT cells are numerically deficient in patients with ARDS. These MAIT cells are activated, migrate into the lung, secrete IL-17, and stimulate macrophages, contributing to the worsening of inflammation in the lung of patients with ARDS.

THORAX (2022)

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Article Chemistry, Multidisciplinary

Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury

Renyikun Yuan et al.

Summary: This study developed a strategy using Fe-Cur NPs as nanozymes to scavenge intracellular ROS and alleviate inflammation synergistically, thereby treat acute lung injury (ALI). The Fe-Cur NPs reduced levels of various inflammatory cytokines, inflammasomes, and signaling pathways, and demonstrated promising therapeutic efficiency in animal experiments. Fe-Cur NPs also effectively reduced macrophage cells and T cells, helping suppress the inflammation cytokine storm caused by ALI.

ACS CENTRAL SCIENCE (2022)

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Article Public, Environmental & Occupational Health

Primary stroke prevention worldwide: translating evidence into action

Mayowa O. Owolabi et al.

Summary: Stroke is a major global threat to life and disability, particularly in low- and middle-income countries that struggle to address its challenges. This article provides an overview of primary stroke prevention, estimating the cost and identifying deficiencies in guidelines and primary prevention approaches. Pragmatic solutions are offered, emphasizing the role of governments and population-wide strategies. Implementation of primary stroke prevention involves various stakeholders across the lifespan.

LANCET PUBLIC HEALTH (2022)

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Review Pharmacology & Pharmacy

Nanotechnology-Driven Cell-Based Therapies in Regenerative Medicine

D. Alzate-Correa et al.

Summary: The administration of cells as therapeutic agents is a new approach to treat diseases. Nanotechnology-driven cell therapies have the potential to overcome challenges related to efficacy, safety, and translational potential.

AAPS JOURNAL (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Accelerate gas diffusion-weighted MRI for lung morphometry with deep learning

Caohui Duan et al.

Summary: The study accelerated multiple b-value gas DW-MRI using deep learning, achieving high-quality reconstructions with faster speed. The DC-RDN demonstrated effectiveness in maintaining accurate estimation of lung microstructural morphometry, showing great potential for studying lung diseases in the future.

EUROPEAN RADIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives

Stephanie Debette et al.

Summary: This review provides an overview of the current knowledge on monogenic and multifactorial forms of stroke, highlighting the potential of stroke genetics to deepen our understanding of stroke pathophysiology, discover new therapeutic approaches, and identify individuals at high risk of stroke.

CIRCULATION RESEARCH (2022)

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Review Cell Biology

Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

An-Guo Wu et al.

Summary: Traumatic brain injury (TBI) is mechanical damage to the brain that impairs normal brain function. Oxidative stress, involving the disruption of blood-brain barrier and damage to lipids, proteins, and DNA, is an important mechanism in TBI. Transcription factor Nrf2 plays a crucial role in regulating antioxidant proteins to protect against oxidative stress, neuroinflammation, and neuronal apoptosis. Phytochemicals, found in fruits, vegetables, grains, and medical herbs, can activate the Nrf2 signaling pathway and have potential therapeutic effects in TBI.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Nanoscience & Nanotechnology

Anti-Parkinsonian Therapy: Strategies for Crossing the Blood-Brain Barrier and Nano-Biological Effects of Nanomaterials

Guowang Cheng et al.

Summary: Parkinson's disease (PD) is a neurodegenerative disease that is becoming increasingly prevalent, especially among older individuals. The development of novel anti-PD drugs is urgently needed, but the blood-brain barrier (BBB) poses a challenge due to its selective permeability. Nanotechnology offers a solution by enhancing BBB permeability, and recent research has shown that nanomaterials can improve PD symptoms through their own nano-bio effects.

NANO-MICRO LETTERS (2022)

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Article Chemistry, Multidisciplinary

2D/3D Multimode Medical Image Registration Based on Normalized Cross-Correlation

Shan Liu et al.

Summary: Image-guided surgery (IGS) reduces tissue damage and improves accuracy and targeting of lesions by increasing visual field. This experiment studies a 2D/3D medical image registration algorithm based on gray level and introduces a new similarity measure and a multiresolution strategy to enhance registration accuracy and efficiency.

APPLIED SCIENCES-BASEL (2022)

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Review Biology

A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders

Dagmara Wrobel-Biedrawa et al.

Summary: Quercetin, a common flavonoid compound with anti-inflammatory and antioxidant properties, has shown therapeutic potential in various central nervous system diseases, particularly in anti-neuroinflammatory effects.

LIFE-BASEL (2022)

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Review Biochemistry & Molecular Biology

Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights

Safir Ullah Khan et al.

Summary: The tumor microenvironment plays a crucial role in tumor progression by releasing molecules that affect various aspects of cancer cells. Among them, CircRNAs have received special attention for their involvement in mutated pathways and their ability to modify the immunological environment to promote tumor growth. CircRNAs also have potential as biomarkers for cancer diagnosis and may offer a novel approach to tumor immunotherapy. However, there is a lack of comprehensive overview on the role of CircRNAs in cancer. This review discusses the various dimensions of CircRNA and their role in tumors.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Chemistry, Multidisciplinary

Recent progresses in exosome-based systems for targeted drug delivery to the brain

Santosh Bashyal et al.

Summary: This article provides an overview of recent exosome-based drug delivery nanoplatforms and discusses the potential of using exosomes as drug delivery vehicles for treating brain diseases. Exosomes possess advantages such as barrier penetration, targeting capability, and stability, but also face challenges that need to be addressed through future research efforts.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Medicine, Research & Experimental

Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Yishu Fan et al.

Summary: Exosomes, cell-derived extracellular vesicles, have been found to play a significant role in the pathogenesis and potential treatment of CNS diseases, by transferring biologically active molecules between different cells and delivering drugs across the blood brain barrier.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Article Neurosciences

Modulation of neural co-firing to enhance network transmission and improve motor function after stroke

Karunesh Ganguly et al.

Summary: This article discusses the need to develop a common neurophysiological framework to understand how neurotechnology alters network activity, with a focus on principles for understanding the role of motor networks in supporting healthy and stroke recovery reach-to-grasp movements. The authors emphasize neural processing at the resolution of single movements and the timescale of neurotechnology application, as well as how this activity might drive long-term plasticity.

NEURON (2022)

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Review Biotechnology & Applied Microbiology

Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Ying Zhang et al.

Summary: Cancer is a global public health problem with challenging treatments. Gene therapy has emerged as a potential solution, but delivery methods are limiting its effectiveness. Exosomes, as therapeutic carriers and diagnostic markers, have gained extensive attention for their favorable characteristics. This review discusses the characteristics of exosomes, their applications in cancer therapy, and the challenges in exosome-mediated nucleic acid delivery for cancer treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Cell Biology

Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides

Zhanchi Zhu et al.

Summary: The study demonstrates that engineered sEVs can effectively treat glioma by crossing the blood-brain barrier and specifically targeting brain tumors. The high targeting efficiency of these dual-modified sEVs for BBB and glioma was confirmed in vitro and in animal models.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Review Neurosciences

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases

Rosalia Fernandez-Calle et al.

Summary: This article reviews the impact of the APOE genotype on late-onset Alzheimer's disease and central nervous system pathology, covering various factors influencing disease development, such as neuroinflammation, cell function, synaptic function, etc.

MOLECULAR NEURODEGENERATION (2022)

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Review Biochemistry & Molecular Biology

Alzheimer's Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms

Asaad A. Abduljawad et al.

Summary: Saponins are plant-derived compounds that exhibit diverse pharmacological potentials, including neuroprotective effects against various neurological disorders. They act through multiple mechanisms, such as scavenging free radicals, modulating signaling pathways, and activating neurotrophic factors. Saponins have significant efficacy, especially against Alzheimer's disease.

MOLECULES (2022)

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Article Multidisciplinary Sciences

Ionizing radiation exposure during adulthood and risk of developing central nervous system tumors: systematic review and meta-analysis

Julie Lopes et al.

Summary: This study conducted a comprehensive evaluation of the relationship between low-to-moderate doses of ionizing radiation (IR) exposure and the risk of brain and central nervous system (CNS) tumors in adults. Through systematic review and meta-analysis, no significant association was found between low-to-moderate doses of IR exposure and the risk of CNS tumors.

SCIENTIFIC REPORTS (2022)

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Article Immunology

Gut microbiota on admission as predictive biomarker for acute necrotizing pancreatitis

Menglian Zou et al.

Summary: This study found that patients with acute necrotizing pancreatitis (NP) have distinct characteristics of intestinal microbiota compared to non-necrotizing pancreatitis (non-NP) patients. Dysbiosis of intestinal microbiota may influence the progression of NP through ketone body or benzoate metabolism. Enterococcus faecium and Finegoldia magna are potential predictors for NP and infected NP.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Pharmacology & Pharmacy

Exosomes as CNS Drug Delivery Tools and Their Applications

Ke Sun et al.

Summary: Central nervous system diseases pose a threat to global health, but developing drugs targeting the CNS is challenging due to the unique characteristics of the brain and spinal cord. Exosomes, as CNS drug delivery tools, stand out for their low immunogenicity, ability to cross the blood-brain barrier, and flexibility in drug encapsulation. Research over the past decade has shown the potential of exosomes in CNS drug delivery, and there are still challenges and prospects to be addressed.

PHARMACEUTICS (2022)

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Review Pharmacology & Pharmacy

Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review

Huxiao Sun et al.

Summary: This article reviews the design and development of curcumin nanoformulations in recent years and introduces their biomedical applications in common inflammatory diseases by regulating macrophage behaviors, thus accelerating therapeutic effects.

PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer's Disease

Mater H. Mahnashi et al.

Summary: In this study, a natural flavone was isolated from Notholirion thomsonianum, which showed effective activity against Alzheimer's, inflammation, and oxidative stress. This discovery could lay a foundation for future research in drug development.

METABOLITES (2022)

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Article

Unique Therapeutic Potentialities of Exosomes Based Nanodrug Carriers to Target Tumor Microenvironment in Cancer Therapy

Safir Ullah Khan et al.

OpenNano (2022)

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Review Chemistry, Inorganic & Nuclear

Tailoring radiotherapies and nanotechnology for targeted treatment of solid tumors

Muhammad Imran Khan et al.

Summary: Existing anticancer therapies lack efficacy and complete cure. Radioactive materials have been used in cancer therapies since 1890, but their clinical utility is restricted due to toxicities. The integration of nanotechnology and radiotherapies has shown promising outcomes. Transforming external radiotherapies into internal ones has become an interesting research area. This review provides a comprehensive overview of various radiotherapies, compares their efficacy and discusses the application of biomaterials in radiotherapies.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Nutrition & Dietetics

Intestinal Microbiota Regulate Certain Meat Quality Parameters in Chicken

Jiaqi Lei et al.

Summary: The intestinal microbiota has a significant impact on the water-holding capacity of muscles in broilers, influencing meat quality. When raised in the same environment, two native breeds of broilers exhibit similarities in muscle water-holding capacity and gut bacteria compositions. Fecal microbiota transplantation experiments show that remodeling the intestinal microbiota can lead to improvements in muscle characteristics.

FRONTIERS IN NUTRITION (2022)

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Article Biotechnology & Applied Microbiology

Extracellular Vesicles in Type 1 Diabetes: A Versatile Tool

Caitlin N. Suire et al.

Summary: Type 1 diabetes is a chronic autoimmune disease that affects a large number of people, and extracellular vesicles (EVs) have the potential to be used as biomarkers for diagnosis and treatment. EVs contain diverse active components and can be transported to specific cells/tissues through the blood system.

BIOENGINEERING-BASEL (2022)

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Article Clinical Neurology

Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

Longfei Jia et al.

Summary: This study showed that exosomal GAP43, neurogranin, SNAP25, and synaptotagmin 1 serve as effective biomarkers for predicting AD 5 to 7 years before cognitive impairment.

ALZHEIMERS & DEMENTIA (2021)

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Review Pharmacology & Pharmacy

An Overview of the Mechanisms of Marine Fungi-Derived Anti-Inflammatory and Anti-Tumor Agents and their Novel Role in Drug Targeting

Syed Shams ul Hassan et al.

Summary: Marine fungi are considered a treasure trove of ocean medicines due to their successful pharmacological effects and the potential of their secondary metabolites. While there is still much to be discovered about the biological actions of these compounds, research on fungi-derived bioactive molecules is crucial for the development of targeted drugs against specific diseases within the body.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Review Pharmacology & Pharmacy

Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments

Flavia Castro et al.

Summary: Erythrocyte-mimicking nanovehicles (EM-NVs) have been extensively studied as biomimetic coating on artificial nanocarriers due to their upgraded biocompatibility, biodegradability, non-immunogenicity, and long-term blood circulation. These EM-NVs have a wide range of applications in drug delivery, imaging, phototherapy, and other areas, showing great potential for therapeutic and diagnostic applications in various diseases.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Pharmacology & Pharmacy

Enhancing Therapeutic Efficacy of Donepezil by Combined Therapy: A Comprehensive Review

Xi Rong et al.

Summary: Combination therapy involving different therapeutic strategies often yields faster and more effective results compared to monotherapy in clinical practice. The acetylcholinesterase inhibitor donepezil, known for its role in Alzheimer's disease, has attracted attention for its neuroprotective, muscle relaxant, and sleep-inducing properties. Recent studies have shown promising results in managing various disorders, including Alzheimer's disease, through the combination of donepezil with other agents.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Biotechnology & Applied Microbiology

The Challenge of Gene Therapy for Neurological Diseases: Strategies and Tools to Achieve Efficient Delivery to the Central Nervous System

Francoise Piguet et al.

Summary: Gene therapy for neurological diseases has seen significant growth in research over the past decade, with advancements in therapeutic interventions for a variety of indications. Improved vector technology has paved the way for treating complex and widespread conditions like Alzheimer's disease and Parkinson's disease. Delivery methods, particularly overcoming the blood-brain barrier, remain a primary focus for improving the efficiency and safety of gene therapy for CNS diseases.

HUMAN GENE THERAPY (2021)

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Review Biochemistry & Molecular Biology

Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles

Asit Kumar et al.

Summary: This review provides an overview of biomaterials as potential drug delivery systems for neurogenerative diseases, discussing the desired properties of effective drug delivery systems and the prospects and limitations of using extracellular vesicles (EVs) as drug delivery systems for targeted delivery with limited immunogenicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Nanoscience & Nanotechnology

Brain penetrating peptides and peptide-drug conjugates to overcome the blood-brain barrier and target CNS diseases

Xue Zhou et al.

Summary: Approximately one in six people worldwide suffer from central nervous system disorders, necessitating effective strategies to improve success rates in CNS drug discovery and development. The presence of the blood-brain barrier (BBB) poses a major obstacle to CNS drug development, but brain-penetrating peptide shuttles and PDCs have shown promise in overcoming this barrier and delivering drug molecules to the brain.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

Amna Akhtar et al.

Summary: The central nervous system (CNS) is considered the most vital part of the human body, with the blood-brain barrier (BBB) posing a significant hurdle for drug transport to the brain. Innovative approaches such as nano-fabricated smart drug delivery systems and implantable drug loaded biomaterials are being developed to overcome this challenge. Recent studies on neural drug discovery and injectable hydrogels show promise in providing new treatment options for neurological disorders and evaluating drug efficacy using induced pluripotent stem cells.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biotechnology & Applied Microbiology

Strategies for delivering therapeutics across the blood-brain barrier

Georg C. Terstappen et al.

Summary: The blood-brain barrier presents a challenge for delivering therapeutics to the central nervous system, particularly for biopharmaceuticals. Non-invasive approaches have been developed to help overcome this challenge, with increasing research efforts focusing on technologies to deliver therapeutics to the CNS, some of which have entered clinical testing. Developing effective strategies for crossing the blood-brain barrier is crucial for treating CNS disorders, with a particular emphasis on non-invasive methods such as receptor-mediated transcytosis and the use of neurotropic viruses, nanoparticles, and exosomes.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Multidisciplinary Sciences

The blood-brain barrier studied in vitro across species

Maj Schneider Thomsen et al.

Summary: The study compared primary BECs from mice, rats, and pigs in different models, revealing potential species-dependent differences in features such as transendothelial electrical resistance (TEER), while showing similar BBB properties in other aspects.

PLOS ONE (2021)

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Review Oncology

Regulation of Antitumor Immune Responses by Exosomes Derived from Tumor and Immune Cells

Andres Rincon-Riveros et al.

Summary: Extracellular vesicles, such as exosomes, have the potential to serve as biomarkers for cancer development, impacting various aspects of tumor progression and immune regulation.

CANCERS (2021)

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Review Oncology

Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development

Arif Tasleem Jan et al.

Summary: Exosomes are membrane-enclosed cellular entities of endocytic origin that shuttle proteins and RNA molecules between cells for communication. They hold promise for drug delivery, but challenges remain in understanding their formation and function under physiological conditions, as well as the lack of methods to illuminate intraluminal vesicle release at target sites. Nonetheless, exosomes offer potential for developing systems that enable the specific delivery of therapeutics in diseases like cancer.

CANCERS (2021)

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Article Cell Biology

Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

Xuan Zhang et al.

Summary: Elevated homocysteine levels are associated with insulin resistance, which is induced by homocysteinylation of the pro-insulin receptor. Homocysteine reacts with and modifies cysteine-825 of pro-IR in the ER, disrupting the original disulfide bond. This modification impairs the interaction between pro-IR and Furin protease in the Golgi apparatus, hindering cleavage of pro-IR and leading to insulin resistance in mice. Inhibiting homocysteinylation could potentially be a new target for drugs to prevent insulin resistance and increase insulin sensitivity.

CELL REPORTS (2021)

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Article Clinical Neurology

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy

Suman Dutta et al.

Summary: The study found that measuring α-syn in exosomes from blood can effectively distinguish between patients with PD and MSA with high sensitivity and specificity. A multinomial logistic model combining α-syn concentration, exosome concentration, and a ratio between α-syn concentrations in specific exosomes showed promising results in separating PD from MSA.

ACTA NEUROPATHOLOGICA (2021)

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Review Pharmacology & Pharmacy

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

Pol Escude Martinez de Castilla et al.

Summary: This systematic review assesses the characteristics and trends of extracellular vesicles (EVs) in pre-clinical applications, providing a reliable basis for future applications of EVs in drug delivery and serving as a reference for regulatory guidelines.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment

Wenli Chen et al.

Summary: This review discusses various approaches to improve transportation of therapeutic agents to the CNS, focusing on the advantages of using BBB-crossing AAVs as gene delivery vectors and the different types of BBB-AAV vectors that have been developed for potential applications in CNS diseases.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Pharmacology & Pharmacy

Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)

Weina Ke et al.

Summary: Exosomes, as endogenous nanocarriers, show great promise in meeting the needs of nucleic acid nanoparticles in diagnostics and therapeutics. Their lipid membranes can carry different types of drugs and nucleic acids simultaneously and be surface modified, expanding their diverse biomedical applications.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Pharmacology & Pharmacy

Clinical translation of immunomodulatory therapeutics

Amanda Nash et al.

Summary: Immunomodulatory therapeutics, with great potential to rebalance malfunctioning immune systems, are quickly becoming one of the fastest-growing areas in the pharmaceutical industry. Despite some success in cancer and autoimmune disease treatment, challenges related to dosing, off-target effects, and manufacturing hurdles still need to be addressed.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Deconstructing Alzheimer's Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

Anais Vignon et al.

Summary: Alzheimer's disease is a common form of dementia with no cure available. Research focuses on the molecular mechanisms of AD to find better models to replicate the pathology. The aim is to help researchers identify the most relevant disease models to advance the field.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Multidisciplinary

Biomimetic and cell-based nanocarriers-New strategies for brain tumor targeting

D. Mendanha et al.

Summary: In the last two decades, significant advances in the treatment of the most common and malignant types of brain tumors have not been achieved, primarily due to difficulties in drug delivery to the central nervous system and associated severe side effects. Research on cell-based nanocarriers is exploring the potential for crossing biological barriers and targeting brain tumors with higher selectivity, offering new hope for safe and effective treatments.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Clinical Neurology

Inflammatory Diseases of the Central Nervous System

Nikita Malani Shukla et al.

NEUROLOGIC CLINICS (2021)

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Article Multidisciplinary Sciences

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk

Xiao-Hui Wang et al.

Summary: Abnormal metabolite levels in the villous tissues inhibit extravillous trophoblast function, leading to an increased risk of recurrent spontaneous abortion (RSA). Modulating succinate levels may serve as a potential intervention strategy for RSA.

NATURE COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

Exosomal delivery of therapeutic modulators through the blood-brain barrier; promise and pitfalls

Morteza Heidarzadeh et al.

Summary: Current drug delivery strategies for neurological disorders face challenges due to the blood-brain barrier (BBB) limiting transport to the brain parenchyma. Stem cell byproducts such as exosomes are proposed as natural nano-drug carriers, but the intact BBB may hinder their delivery. Understanding the molecular mechanisms behind exosomal trafficking through the BBB remains unclear despite some preliminary studies showing potential.

CELL AND BIOSCIENCE (2021)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

Mangesh D. Hade et al.

Summary: Exosomes are extracellular vesicles secreted by almost all cell types to aid in various cellular functions, including intercellular communication and immune signaling. They carry a multitude of signaling moieties, making them potential candidates for tissue engineering and regenerative medicine. The review highlights the emerging roles and potential applications of exosomes in regenerative medicine, particularly in brain injuries, cardiovascular disease, and COVID-19.

CELLS (2021)

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Article Dentistry, Oral Surgery & Medicine

Extracellular vesicles as a novel therapeutic tool for cell-free regenerative medicine in oral rehabilitation

Longwei Lv et al.

JOURNAL OF ORAL REHABILITATION (2020)

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Review Clinical Neurology

Parkinson disease

R. Balestrino et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Article Neurosciences

Macrophage-Derived Extracellular Vesicles as Drug Delivery Systems for Triple Negative Breast Cancer (TNBC) Therapy

Matthew J. Haney et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2020)

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Article Cell Biology

Pigment Epithelium-Derived Factor Improves Paracellular Blood-Brain Barrier Integrity in the Normal and Ischemic Mouse Brain

Arina Riabinska et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2020)

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Article Immunology

Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice

Niansheng Lai et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Engineering, Biomedical

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Zhaogang Yang et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Cardiac & Cardiovascular Systems

Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

Li Yang et al.

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Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia

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Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes

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Exosomes from MSCs overexpressing microRNA-223-3p attenuate cerebral ischemia through inhibiting microglial M1 polarization mediated inflammation

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Inhibition of Glioma Cells' Proliferation by Doxorubicin-Loaded Exosomes via Microfluidics

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Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles

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Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock

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Exosomes-beyond stem cells for restorative therapy in stroke and neurological injury

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Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

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Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury

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Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

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Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

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Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood-brain barrier penetration

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Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson's Disease Model

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Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2

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Exosomes derived from induced vascular progenitor cells promote angiogenesis in vitro and in an in vivo rat hindlimb ischemia model

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Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

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Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

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YBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT

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Extracellular Vesicle-Mediated Cell-Cell Communication in the Nervous System: Focus on Neurological Diseases

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Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes

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Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

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Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances

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A window into the brain: Tools to assess pre-clinical efficacy of biomaterials-based therapies on central nervous system disorders

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Mesenchymal stem cell-derived exosomal microRNA-133b suppresses glioma progression via Wnt/β-catenin signaling pathway by targeting EZH2

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Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

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Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

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Engineered exosomes: A new promise for the management of musculoskeletal diseases

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

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Exosomes in lung cancer diagnosis and treatment. From the translating research into future clinical practice

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

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Role of Exosomes Derived from miR-133b Modified MSCs in an Experimental Rat Model of Intracerebral Hemorrhage

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Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses

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Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

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Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

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Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson's disease treatment

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Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function

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Exosomes derived from PEDF modified adipose-derived mesenchymal stem cells ameliorate cerebral ischemia-reperfusion injury by regulation of autophagy and apoptosis

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Heat Shock Proteins in Alzheimer's Disease: Role and Targeting

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Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

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Recent advancements in the use of exosomes as drug delivery systems

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

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Exosomes of human placenta-derived mesenchymal stem cells stimulate angiogenesis

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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

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Current status and future therapeutic perspectives of glioblastoma multiforme (GBM) therapy: A review

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MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

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Alzheimer's Disease and Molecular Chaperones: Current Knowledge and the Future of Chaperonotherapy

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CURRENT PHARMACEUTICAL DESIGN (2016)

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Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury

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Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a

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Extracellular vesicles: masters of intercellular communication and potential clinical interventions

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Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

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JOURNAL OF CONTROLLED RELEASE (2016)

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Global Burden of Disease Study 2015 provides GPS for global health 2030

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Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

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Exosomes as miRNA Carriers: Formation-Function-Future

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Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

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Exosomes as drug delivery vehicles for Parkinson's disease therapy

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Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

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PHARMACEUTICAL RESEARCH (2015)

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Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

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Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro

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Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

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NATURE COMMUNICATIONS (2015)

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Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

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SCIENTIFIC REPORTS (2015)

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Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4/β-Catenin Pathway

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CURRENT OPINION IN CELL BIOLOGY (2014)

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Rabies Virus Envelope Glycoprotein Targets Lentiviral Vectors to the Axonal Retrograde Pathway in Motor Neurons

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Systemic Exosomal siRNA Delivery Reduced Alpha-Synuclein Aggregates in Brains of Transgenic Mice

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Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

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PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

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Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

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Glioblastoma and Other Malignant Gliomas A Clinical Review

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

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Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

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MOLECULAR & CELLULAR PROTEOMICS (2013)

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Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

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AMERICAN JOURNAL OF PATHOLOGY (2012)

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Exosome mimetics: a novel class of drug delivery systems

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Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

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NUCLEIC ACIDS RESEARCH (2012)

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Emerging role of neuronal exosomes in the central nervous system

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Inhibition of Myelin Membrane Sheath Formation by Oligodendrocyte-derived Exosome-like Vesicles

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Matrix Metalloproteinase-9 and Stromal Cell-Derived Factor-1 Act Synergistically to Support Migration of Blood-Borne Monocytes into the Injured Spinal Cord

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Huntington's disease: from molecular pathogenesis to clinical treatment

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Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

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SEMINARS IN IMMUNOPATHOLOGY (2011)

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MiR-146b-5p Suppresses EGFR Expression and Reduces In Vitro Migration and Invasion of Glioma

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells

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Drug addictions: towards socially accepted and medically treatable diseases

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Applications of Extracellular Vesicles in Nervous System Disorders: An Overview of Recent Advances

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