期刊
NON-CODING RNA
卷 8, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ncrna8060082
关键词
long noncoding RNA; cancer; conservation
资金
- Swiss National Science Foundation through the National Centre of Competence in Research (NCCR) [51NF40-182880, 31003A_182337, 173738]
- SNF [P1BEP3_199932]
- Medical Faculty of the University of Bern
- Inselspital University Hospital of Bern
- Helmut Horten Stiftung
- Swiss Cancer Research Foundation [4534-08-2018]
- Werner and Hedy Berger Janser-Foundation for cancer research
- Science Foundation Ireland through Future Research Leaders award [18/FRL/6194]
- NIH [R35 CA232105]
- Swiss National Science Foundation (SNF) [31003A_182337, P1BEP3_199932, 51NF40-182880] Funding Source: Swiss National Science Foundation (SNF)
This study has found a bias in the evaluation of evolutionary conservation for cancer-related lncRNAs, raising doubts about its relevance in cancer research.
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in the selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for the prioritisation of cancer-related lncRNAs.
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