A 2D Porous Zinc-Organic Framework Platform for Loading of 5-Fluorouracil

A hydrostable 2D Zn-based MOF, {[Zn(5-PIA)(imbm)]center dot 2H(2)O}(n) (1) (5-H(2)PIA = 5-propoxy-isophthalic acid, imbm = 1,4-di(1H-imidazol-1-yl)benzene), was synthesized and structurally characterized. Complex 1 shows good water and thermal stability based on the TGA and PXRD analyses and displays a 2D framework with 1D channels of 4.8 x 13.8 and 10.0 x 8.3 angstrom(2) along the a axis. The 5-fluorouracil (5-FU) payload in activated complex 1 (complex 1a) is 19.3 wt%, and the cumulative release value of 5-FU at 120 h was about 70.04% in PBS (pH 7.4) at 310 K. In vitro MTT assays did not reveal any cytotoxic effect of NIH-3T3 and HEK-293 cells when the concentration of 1 was below 500 mu g/mL and 5 mu g/mL, respectively. No morphological abnormalities were observed on zebrafish exposed to complex 1.

Automated summary

A hydrostable 2D Zn-based MOF with good water and thermal stability was synthesized and characterized. It showed potential for controlled drug release and exhibited low cytotoxicity towards cells and zebrafish.