期刊
JOURNAL OF FUNCTIONAL BIOMATERIALS
卷 13, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jfb13040274
关键词
metal oxide nanoparticles; nanotechnology; pro-regenerative potential; cancer therapy; antimicrobial activity; nanotoxicity
The progress in nanotechnology has led to the development of metal oxide nanoparticles with unique physicochemical characteristics for biomedical applications. Despite their advantages, these nanoparticles can have cytotoxic effects, which can be reduced by better control of the synthetic parameters.
In the last few years, the progress made in the field of nanotechnology has allowed researchers to develop and synthesize nanosized materials with unique physicochemical characteristics, suitable for various biomedical applications. Amongst these nanomaterials, metal oxide nanoparticles (MONPs) have gained increasing interest due to their excellent properties, which to a great extent differ from their bulk counterpart. However, despite such positive advantages, a substantial body of literature reports on their cytotoxic effects, which are directly correlated to the nanoparticles' physicochemical properties, therefore, better control over the synthetic parameters will not only lead to favorable surface characteristics but may also increase biocompatibility and consequently lower cytotoxicity. Taking into consideration the enormous biomedical potential of MONPs, the present review will discuss the most recent developments in this field referring mainly to synthesis methods, physical and chemical characterization and biological effects, including the pro-regenerative and antitumor potentials as well as antibacterial activity. Moreover, the last section of the review will tackle the pressing issue of the toxic effects of MONPs on various tissues/organs and cell lines.
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